University of Groningen
Fructose-1,6-bisphosphate and its role on the flux-dependent regulation of metabolism
Bley Folly, Brenda
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Publication date:
2018
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Bley Folly, B. (2018). Fructose-1,6-bisphosphate and its role on the flux-dependent regulation of
metabolism. University of Groningen.
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Acknowledgements
Almost five years ago I packed my life in two suitcases and moved to Groningen to start my PhD. I really enjoyed these PhD years, where I could learned a lot about science, about people and friendship, and a lot about myself. This thesis would not have been possible without the essential help of a lot of people that contributed to it in so many different ways. And now, it’s time to thank everyone that helped and supported me during all these years.
First, Matthias, thank you for the great opportunity to work on your lab during these years, and for never stop believing in me. I will never forget that “difficult” meeting we had, about 3 years ago. Those 3 hours of conversations changed the course of my PhD. Thank you for always been so open, for your support, and for everything I have learned with you.
Thank you Dr. Marco Fraaije, Dr. Dirk Slotboom and Dr. Paola Picotti for being part of the assess-ment committee. Thank you very much for reading my thesis and for your feedback.
Thank you my dear paranymph Silke, because, literally, this thesis would not have been possible without you. Especially in the last months of my PhD, your help in the lab was crucial. It was a lot of fun to work with you in the lab. Thank you also for always helping me to keep on going, and for supporting and “kicking me” every time I needed. I really appreciated that Silke.
Thank you my other dear paranymph, Vakil, (and Alisa, my “co-paranymph”) who brought extra join to my PhD life. Thanks for all the coffees, talks and parties we had together. And a special thanks to all the hugs that you both freely distributed in the corridors during these years, they were essential to keep “all the parts in place”.
Thank you, my dear Kuba, for your great friendship during all these years. Thank you for under-standing me, for our endless talking, for always believing that I could and I would, for always “petting” me when I needed (even though I said I hated it), for all the parties and fun we had together. Thanks because you also helped me a lot with my work, always with some great sugges-tions, and nice discussions about my project. Kuba, thanks for being the best friend I could have had during my PhD. Friends like you that are always there no matter what, are a rare thing, and I am lucky to have a friendship like that in my life.
Thank you Alwin. You always inspired me to travel more and explore different places. And you were part of this adventure of moving to The Netherlands and starting my PhD even before it started. It was great to have you here, especially in the very beginning when everything was new and different. You helped me to find my way here, and you gave me support to really “go for it” and never give up. Thank you very much for everything you ever did for me.
Conclusions and outlook Thank you Jonas. You were the very first person I met “on the other side of the corridor”. I
remember that I knocked on your office, you helped me, and that is how I made my very first friend in Groningen. Thank you for all the great moments we shared doing extremely important and completely unrelated work stuff, and for the fact that our friendship continues beyond our PhD life.
Thank you Antonija. I don’t even know how to start thanking you, my dear. Especially in the last months of writing the thesis, when you showed me what a real friendship is by taking care of me when I needed it the most. Eric and Antonija, thank you for all the dinners, the deserts and the laughs we shared.
Thank you all the members from the Molecular systems biology group. Thank you Alex, Kuba, Zheng, Georg, Francisca, Joana, Yin, Haoqi, Simeon, Serdar, Yonathan, Silke and Tom for the fun we had in the lab. And a special thanks Alvaro, Thanasis, Bastian, Daphne, Hannah and Vakil for also sharing the office with you. You were always a great support on daily basis, and great fun to have around.
Thank you Alvaro for all your help, for all the scientific discussions, for your advices and for all the nice times we had during all these years. Working with FBP was not always easy (or, never!), but it was great to have you also working with this lovely molecule so we could discuss and complain about it together. I really admire the way you work, and you always inspired me.
Thank you Renate. You like to talk just like me, and it was always nice to go to your office or meet you by accident in the corridor and discuss about endless subjects. Thanks for being always so open and for providing a great support for the MSB group, in all senses.
Thank you Johan. I met you even before you joined the MSB group, when you helped me making beautiful crystals of Hxk2.Thank you for sharing your crystallography knowledge with me, and for all your help during the Hxk2 project. Thanks also for all the coffees and talks we had.
Thank you Pieter. For the endless times you helped me with all different and “mysterious” types of NMR, which I never had heard about before. It was great to work with you and to learn a bit more about NMR. Thanks for sharing your knowledge with me, for helping me so much in many different projects, for all the scientific discussions we had, and of course, for all the coffees and nice conversations we had.
Thank you Gea, Ria and Christiaan. Without you I would not having been able to do my research, and you know that I really mean it. Thank you for all your support by letting me use equipment and reagents (shopping again, Brenda? Says Gea) in your labs, and for helping me by sharing your
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knowledge with me. Thank you for running the labs so smoothly, which helps each one of us to work better, and for creating a great atmosphere in the labs.
Thank you for the members of the “Poolman lab”. I worked so much in your labs that I almost felt like part of the group. Thank you for always being so nice to me, for helping me and for having so much fun together. A very special thanks to Weronika, Christofer, Adi, Boqun, Albert, Alisa, Arnold, Joury and Lukas for all the “incredible knowledge” you shared with me, the amazing laughs and beers (ok Lukas, coke) we had together.
Thank you Marten Exterkade. Thank you for all the talking and the coffees we shared during the endless MSTs I did in your lab. You helped me by making my “experimental frustrations” feel lighter.
Thank you to Jasper Paauwe and Vitali Laba. It was great to have you as my students. Thank you for helping me on my research, and for all the nice discussions and brainstorms that we had. Jas-per, thank you because you kept on coming back to have coffees and more coffees with me, many years after you finished your project (I hope it was not only because the coffees were free… ;) Thank you for the members of “Fraaije and Janssen group”. Thank you for letting me use so many things from your lab. I always felt welcome and almost like a member of the group. Well, now I am, and it is great to be “on the other side of the wall” working with you guys. Some of you I know since the beginning of my PhD, and it was always great to party with you, have some proper summer days barbecuing in the park and going the lake. Thank you to all of you, guys! I wanted to give a special thanks to the closer “old ones” Nikola, Elvira, Antonija, Hemant, Mohamed, Dana, Hein, Misun, Friso, Marzena, Aline, Nina, Gosia and the closer “new ones” Gautier, Jeroen, Estela, Bombino, Alejandro, Fabiola and Nikolas. A special thanks to Marco, for having me in his lab and in Oxytrain in the past year.
Thank you the PhD Day board 2014 and the Gopher board 2015: Keri, Naomi, Anne, Nicky, Maarten, Linda, Els, Simon, Christel, Wouter and Ni. Thank you guys for the opportunity to orga-nize so many different events with you. It was a great distraction from the long days in the lab. Thank you Samira, Paola e Paula, my dear friends from Brazil. Muito obrigada pela amizade incondicional e verdadeira de vocês gurias. Não importa quão longe a gente esteja, ou quão pouco a gente se veja, nada muda quando nos encontramos. O apoio e a amizade de vocês é fundamental na minha vida, pois eu sei que vocês sempre estarão aí pra mim. Obrigado por aceitarem e apoiarem todas as decisões que tomei nesses últimos anos.
Muito obrigada a toda a minha família que está no Brasil. Em especial, eu gostaria de agradecer a tia Sônia e o tio Dorival, que sempre me apoiaram durante toda essa jornada.
Conclusions and outlook Thank you Anna, Joop, Roos, Maarten and Linda. I would like to thank you all for the support
you gave me during this last year of my PhD. Thank you for having me in your family, for the nice dinners, coffees, concerts and parties we shared, and for the nice talks we had.
Thank you Felipe. My dear brother, you were always an example to me. I admired your discipline and commitment, and that always inspired me. I wish I was a little bit more like you ;) Thank you for living in Germany, it is wonderful to have some family “around”! Thank you for all the support you always gave to me, for taking care of me and for your honesty when I mostly needed. Thank you Ron, meu amor. You were my favorite distraction during this (crazy) last year of PhD. A lovely and essential support that came in the perfect time ;) Thank you for your love, for celebrat-ing every small achievement with me, for supportcelebrat-ing me on everythcelebrat-ing I needed, for the cover of my thesis and all the other technical stuff, and for cooking for me so many times. Thank you for understanding me and for helping me when I mostly needed. I’m really looking forward to a time in our lives free of all the PhD obligations.
Last but definitely not least, thank you to my parents. Mãe e pai, muito obrigada por nos ensina-rem a importância de uma boa educação, e por investiensina-rem em nós. Muito obrigada pelo amor de vocês, por sempre celebrarem minhas conquistas, por me incentivarem e por me apoiarem incondicionalmente. É maravilhoso saber que posso sempre contar com vocês, independente de quão longe nós estejamos. Tudo que sou e que conquistei devo a vocês, não sei nem como agradecer por tudo que vocês fizeram e fazem por mim. Muito obrigada mesmo!
