University of Groningen
Fructose-1,6-bisphosphate and its role on the flux-dependent regulation of metabolism Bley Folly, Brenda
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Bley Folly, B. (2018). Fructose-1,6-bisphosphate and its role on the flux-dependent regulation of metabolism. University of Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Propositions
Accompanying the thesis
Fructose-1,6-bisphosphate and its role on the flux-dependent regulation of
metabolism
Brenda Bley Folly
1. In order to increase our knowledge of a flux-sensing regulatory system it is necessary to first determine the elements that form such a system, and second, understand how these different regulatory elements are connected. (Chapter 1 and 5)
2. Fructose-1,6-bisphosphate (FBP), by acting as a chelator, can be part of a new regulatory mechanism, where the activity of enzymes can be globally, but indirectly, regulated by metabolites chelating metal ions. (Chapter 2 and 3)
3. Negative results are just what I want. They’re just as valuable to me as positive results. I can never find the thing that does the job best until I find the ones that don’t. (Thomas A. Edison)
4. High throughput methods generate lots of data and hypotheses, but it is important that these are validated by classical biochemical analyses. Such biochemical analyses can open new avenues for future research. (Chapter 2 and 3)
5. Fructose-1-phosphate (F1P) is the metabolic regulator that modulates the activity of the transcription factor Cra in a specific manner, but not FBP. (Chapter 4)
6. Do not trust any “scientific information” that is followed by the words “data not shown”.
(Chapter 4)
7. Collaboration in science is essential: we cannot accomplish all that we need to do without working together. (Modified from Bill Richardson)
8. Education (PhD) is not the learning of facts, but the training of the mind to think. (Albert Einstein)
9. You should sit in meditation for 20 minutes a day, unless you are too busy; then you should sit for an hour. (Old Zen saying)
