University of Groningen
C/EBPβ isoforms and the regulation of metabolism
Ackermann, Tobias
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Ackermann, T. (2018). C/EBPβ isoforms and the regulation of metabolism: A fine balance between health and disease. University of Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
C/EBPβ isoforms and the
regulation of metabolism
A fine balance between health and disease
PhD thesis
By
ISBN (book): 978-94-034-1117-0 ISBN: (e-book): 978-94-034-1116-3
Cover design and layout: Tobias Ackermann
C/EBPβ isoforms and the regulation of
metabolism
A fine balance between health and disease
PhD thesis
To obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 29 October 2018 at 16:15.
By
Tobias Ackermann
Born on 27 November 1987 In Jena, Germany
Supervisor
Prof. C. F. Calkhoven
Co-supervisor
Dr. G. Hartleben
Assessment committee
Prof. G. de Haan
Prof. A. J. A. van der Sluis
Prof. P. J. Coffer
Paranymphs
Gertrud Kortman Tobias Krauße Britt Sterken
Table of contents
Chapter I Aim and outline of the thesis 9
Chapter II Cancer cell metabolism and its regulators 13 Chapter III Deficiency in mTORC1-controlled C/EBPβ-mRNA
translation improves metabolic health in mice
39
Chapter IV C/EBPβ-LIP induces tumour metabolic reprogramming by regulating the let-7/LIN28B circuit
77
Chapter V Stimulation of the malate aspartate shuttle by C/EBPβ-LIP causes glycolysis addiction
115
Chapter VI Discussion and perspectives 143
Appendices Scientific summary
Wetenschappelijke samenvatting
159 161
Lay summaries 165
