University of Groningen
Treatment of neonatal hyperbilirubinemia van der Schoor, Lori
DOI:
10.33612/diss.98066613
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Publication date: 2019
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van der Schoor, L. (2019). Treatment of neonatal hyperbilirubinemia: Phototherapy and beyond. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.98066613
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Treatment of Neonatal Hyperbilirubinemia
Phototherapy and Beyond
Lori Wilhelmina Everhild van der Schoor
Geboren op 21 mei 1992, te Groningen
The work described in this thesis was performed at the Department of
Pediatrics, Section Molecular Metabolism and Nutrition and the Department of Neonatology and the Beatrix Children’s Hospital, Universital Medical Center Groningen, The Netherlands and the Department of Pharmacology at the University of California San Diego.
The author gratefully acknowledges the financial support for this work by:
Junior Scientific Masterclass (JSM) Groningen KNAW Ter Meulen Fonds
Dr. C.J. Vaillant Fonds
Stichting Vrienden Beatrix Kinderziekenhuis
and the financial support for printing this thesis by:
Ausnutria B.V. Hero Benelux FrieslandCampina
Graduate School of Medical Sciences, Research Institute for Drug Exploration (GUIDE)
Nederlandse Vereniging voor Hepatologie (NVH)
Cover design: Dennis Molema ISBN: 978-94-6375-516-0
Printed by: Ridderprint B.V. Ridderkerk, The Netherlands. www.ridderprint.nl
Copyright
All rights reserved. No part of this publication may be reproduced, distributed, stored in a retrieval system, or transmitted, in any form or by any means, without permission of the author and the publisher holding respective copyrights of the published articles, if applicable.
Treatment of Neonatal Hyperbilirubinemia
Phototherapy and Beyond
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de
rector magnificus prof. dr. T.N. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 23 september 2019 om 16.15 uur
door
Lori Wilhelmina Everhild van der Schoor
Promotores Prof. dr. H.J. Verkade Prof. dr. J.W. Jonker Co-promotor Dr. C.V. Hulzebos Beoordelingscommissie Prof. dr. R.H.J. Houwen Prof. dr. A.F. Bos Prof. dr. P.L.P. Brand
Paranimfen
Maaike Blankestijn Marleen Dommerholt
Contents
Chapter 1 General Introduction 9
Chapter 2 New Insights in the Biology of ABC 55 Transporters ABCC2 and ABCC3:
Impact on Drug Disposition
Chapter 3 Unconjugated Free Bilirubin in 113 Preterm Infants
Chapter 4 LED Phototherapy does not induce 143 Oxidative DNA Damage in
Hyperbilirubinemic Gunn rats
Chapter 5 LED Phototherapy in Preterm Infants: 169 Effects on a Marker of Oxidative
DNA damage
Chapter 6 Potential of Therapeutic Bile Acids 193 in the Treatment of Neonatal
Hyperbilirubinemia
Chapter 7 General Discussion and 221 Future Perspectives
Appendices English Summary 245 Nederlandse Samenvatting
Acknowledgements Biography
Biografie
