University of Groningen
Diabetes mellitus and rhegmatogenous retinal detachment
Fokkens, Bernardina Teunisje
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Publication date: 2017
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Fokkens, B. T. (2017). Diabetes mellitus and rhegmatogenous retinal detachment: Exploring the role of advanced glycation endproducts in systemic and local disease. Rijksuniversiteit Groningen.
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Diabetes Mellitus and
Rhegmatogenous Retinal Detachment
Exploring the role of advanced glycation
endproducts in systemic and local disease
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Financial support for this thesis was provided by University Medical Center Groningen, Junior Scientific Masterclass, Graduate School of Medical Sciences, Stichting Blindenhulp, and Prof. Mulder Stichting.
Financial support for printing of this thesis was kindly provided by DiagnOptics Technologies B.V.
Layout Bianca Pijl, www.pijlldesign.nl, Groningen, The Netherlands Cover design Bianca Pijl
Printed by Ipskamp Printing
Enschede, The Netherlands ISBN 978-94-034-0130-0 (print)
978-94-034-0129-4 (digital)
© Copyright 2017 Bernardina T. Fokkens, Groningen, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
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Diabetes mellitus and rhegmatogenous
retinal detachment
Exploring the role of advanced glycation
endproducts in systemic and local disease
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus, prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 13 november 2017 om 16.15 uur
door
Bernardina Teunisje Fokkens
geboren op 30 september 1990513401-L-sub01-bw-Fokkens 513401-L-sub01-bw-Fokkens 513401-L-sub01-bw-Fokkens 513401-L-sub01-bw-Fokkens Processed on: 23-10-2017 Processed on: 23-10-2017 Processed on: 23-10-2017
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Promotores
Prof. dr. A.J. Smit
Prof. dr. J.M.M. Hooymans Copromotores Dr. D.J. Mulder Dr. L.I. Los Beoordelingscommissie Prof. dr. H.J.G. Bilo Prof. dr. R.A. Bank Prof. dr. B.J. Klevering
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5 Table of contents
Chapter 1
Part I. Skin autofluorescence in diabetes mellitus
Chapter 2
Chapter 3
Part II. Advanced glycation endproducts in rhegmatogenous retinal detachment patients Chapter 4 Chapter 5 Chapter 6 Chapter 7 7 25 41 63 77 91 107 119 127 133 137 General introduction
Review: Skin fluorescence as a clinical tool for non-invasive assessment of advanced glycation and long-term complications of diabetes
Skin autofluorescence improves the Finnish Diabetes Risk Score in the detection of diabetes in a large population based cohort – the LifeLines cohort study
Pilot study: Skin autofluorescence is increased in patients with a severe retinal detachment
Surface area of detachment, proliferative vitreoretinopathy, and pulse pressure, but not AGEs, are associated with retinal redetachment
Vitreous advanced glycation endproducts and α-dicarbonyls in retinal detachment patients with type 2 diabetes mellitus and non-diabetic controls
Summary, discussion, and future perspectives Nederlandse samenvatting (Dutch summary) Dankwoord (Acknowledgments)
Curriculum vitae Bibliography
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