University of Groningen
Radiation-induced cellular senescence in salivary glands Peng, Julie
DOI:
10.33612/diss.103407924
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Publication date: 2019
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Peng, J. (2019). Radiation-induced cellular senescence in salivary glands. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.103407924
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Radiation-induced cellular
senescence in salivary glands
Xiaohong Peng
Peng, X.
Radiation-induced cellular senescence in salivary glands
PhD dissertation, University of Groningen, Groningen, The Netherlands
Printing of this thesis was financially supported by the Graduate School of Medical Sciences, University of Groningen.
Cover: Xiaohong Peng
Layout: Xiaohong Peng, Peisen Su
Printed by: Ridderprint, www.ridderprint.nl
ISBN electronic version: ISBN 978-94-6375-695-2 ISBN printed version: ISBN
Copyright © 2019, Peng. X, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise without prior written permission of the author.
Radiation-induced cellular
senescence in salivary glands
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Wednesday 4 December 2019 at 11.00 hours
by
Xiaohong Peng
born on 02 March 1988
Promotor
Prof. R.P. Coppes
Co-promotor
Dr. L. Barazzuol
Assessment Committee
Prof. M.A.T.M. van Vugt Prof. N. Cordes
Prof. M.A.G.G. Vooijs
Paranymphs
Yi Wu
To my family To my mother
Table of Contents
Chapter 1 General introduction and thesis outline 9
Chapter 2 Role of glial-cell-derived neurotrophic factor in salivary gland stem cell response to irradiation
Radiother Oncol. 2017; 124: 448-454
41
Chapter 3 Cellular senescence contributes to radiation-induced hyposalivation by affecting the stem and progenitor cell niche
Manuscript submitted
65
Chapter 4 GDNF – a marker for radiation induced senescence in salivary glands
Manuscript in preparation
93
Chapter 5 Differential cellular senescence response of salivary gland organoids after low and high LET radiation
Manuscript in preparation as short communication
123
Chapter 6 Summary and future perspectives 139
Appendices Dutch summary Acknowledgements Curriculum vitae List of publications
155
