University of Groningen
Birth and death of cellular senescence Wang, Boshi
DOI:
10.33612/diss.131223530
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Wang, B. (2020). Birth and death of cellular senescence. University of Groningen. https://doi.org/10.33612/diss.131223530
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These propositions belong to the PhD thesis entitled
Birth and death of cellular senescence
1. Chemotherapy-induced senescent normal cells exert toxic effects. [This thesis]
2. Pharmacological inhibition of Cyclin Dependent Kinases (CDK) 4/6 induces cellular senescence in normal fibroblasts and mice. [This thesis]
3. CDK4/6 inhibitor-induced irreversible growth arrest is p53-dependent. [This thesis]
4. CDK4/6 inhibitor-induced senescence activates a secretory program (SASP) enriched in p53-associated factors but without pro-inflammatory and
detrimental NF-κB-dependent factors. [This thesis]
5. CDK4/6 inhibitor-induced senescent cells are well tolerated in vivo. [This thesis]
6. Short-term treatment of CDK4/6 inhibitors on chemotherapy-induced
senescent cells partially reduces established detrimental NF-κB-dependent SASP factors via p53 activation and NF-κB repression and improves the healthspan of treated mice. [This thesis]
7. Senescent cells naturally accumulate during the aging processes in mice and humans. [This thesis]
8. Depletion of age-associated p16+ senescent cells improves mouse
healthspan. [This thesis]
9. Accumulation of senescent cells is dependent on immune functions and is gender-specific. [This thesis]
10. It is not flesh and blood but the heart which makes us fathers and sons. [Johann Schiller]
Boshi Wang 2020
