Citation
Bilgin, M. Y. (2011, September 28). Transfusion associated complications in cardiac surgery : the swan song of the allogeneic leukocytes ?. Retrieved from
https://hdl.handle.net/1887/17880
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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TRANSFUSION-ASSOCIATED COMPLICATIONS IN
CARDIAC SURGERY:
THE SWAN SONG OF THE ALLOGENEIC LEUKOCYTES?
Memiş Yavuz Bilgin
All rights reserved. No part of the material protected by this copyright notice may be reproduced or utilized in any form or by any electronic, mechanical, or other means, now known or hereaft er invented, including photocopying and recording, or in any information storage and retrieval system without prior written permission of the author.
TRANSFUSION-ASSOCIATED COMPLICATIONS IN
CARDIAC SURGERY:
THE SWAN SONG OF THE ALLOGENEIC LEUKOCYTES?
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnifi cus prof. mr. P. F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op woensdag 28 september 2011
klokke 16.15 uur
door
Memiş Yavuz Bilgin
geboren te Eindhoven in 1970Prof.Dr. J.C. Kluin-Nelemans (UMCG, Groningen)
Prof.Dr. E.C. Vamvakas (Cedars-Sinai Medical Center, Los Angeles)
Part of the research described in this thesis was supported by a grant of the Netherlands Heart Foundation (NHF-1998B183).
Financial support by the Netherlands Heart Foundation for publication of this thesis is gratefully acknowledged.
Printing of this thesis was fi nancially supported by Sanquin Research and Fresenius Kabi Netherlands.
Contents
Chapter 1 General introduction 7
Chapter 2 Double-blind randomized controlled trial on the eff ect of 27 leukocyte-depleted erythrocyte transfusions in cardiac
valve surgery
Chapter 3 Is increased mortality associated with postoperative infections 43 aft er leukocytes containing red blood cell transfusions in cardiac surgery? An extended analysis
Chapter 4 Transfusion-related immunomodulation (TRIM): 59 A second hit in an infl ammatory cascade?
Chapter 5 Th e eff ects of allogeneic leukocytes in blood transfusions 81 during cardiac surgery on infl ammatory mediators and
postoperative complications
Chapter 6 Mannose-binding lectin is involved in multiple-organ- 101 dysfunction-syndrome aft er cardiac surgery: eff ects of blood
transfusions
Chapter 7 Cost-eff ectiveness of leukocyte-depleted erythrocyte 115 transfusion in cardiac valve surgery
Chapter 8 Postoperative complications associated with transfusion of 131 platelets and plasma in cardiac surgery
Chapter 9 Discussion and future perspectives 149
Chapter 10 Summary/Samenvatting 165
