University of Groningen
The Role of Structural Dynamics in Protein Function and Evolvability
Muthahari, Yusran
DOI:
10.33612/diss.155494424
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Publication date:
2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Muthahari, Y. (2021). The Role of Structural Dynamics in Protein Function and Evolvability. University of
Groningen. https://doi.org/10.33612/diss.155494424
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Muutthhaahhaarrii
1. Fa Innama’al ‘usri Yusra(n). Surely, with hardship comes ease. (QQuurraann 9944 –– ‘‘TThhee RReelliieevvee’’::55) 2. My thirst for knowledge cannot be quenched. (RRuubbiicckk,, TThhee GGrraanndd MMaagguuss –– DOTA2
Character)
3. While physics laws provide an array of options, nature has to select the one (i.e., set of conformations) which is suitable for the cell to remain functional. (CChhaapptteerr 11, adapted from words of M. de Boer)
4. Francis would have to agree. Even though he was a physicist, he knew that important biological objects come in pairs. (JJaammeess WWaattssoonn – The Double Helix p. 168)
5. The consensus/model of the ancestral cherry-core (CC) showcased a remarkable symmetry between a pair of Rosmann-fold Domains which may contribute to its conformational variability and plasticity. (CChhaapptteerr 22)
6. Comparative structural- and evolutionary-analysis reveals that cherry-core proteins (CCPs) have evolved from a common ancestor into several classes that differ with respect to their termini. (CChhaapptteerr 22)
7. Modular additions of domains or secondary structure elements at the termini confer distinct multi-tier structural dynamics to the core. (CChhaapptteerr 33)
8. The CC bearing an N-terminal domain harboring the HTH type DNA binding ‘core’ but no C-tail yields transcription factors of the LTTR family and binds transcriptional effectors by an apparent lock-and-key mechanism. (CChhaapptteerr 44)
9. Nature might introduce ‘modules’ into highly-evolvable protein cores to allow their functional specialization during evolution. (CChhaapptteerr 55)
10. The energetic arguments might be seen as the main selective pressure during evolution. Significantly, the tight interconnection between protein evolution and protein biophysics emerged during the completion of this thesis. (this thesis perspective and also adapted from
T
Toobbiiaass SSiikkoosseekk and HHuuee SSuunn CChhaann - Biophysics of Protein Evolution and Evolutionary Protein Biophysics)
