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University of Groningen Developmental and pathological roles of BMP/follistatin-like 1 in the lung Tania, Navessa

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University of Groningen

Developmental and pathological roles of BMP/follistatin-like 1 in the lung

Tania, Navessa

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Tania, N. (2017). Developmental and pathological roles of BMP/follistatin-like 1 in the lung. University of Groningen.

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Developmental and Pathological Roles

of BMP/Follistatin-like 1 in the Lung

PhD thesis

to obtain the degree of PhD at the

University of Groningen

on the authority of the

Rector Magnificus Prof. E. Sterken

and in accordance with

the decision by the College of Deans.

This thesis will be defended in public on

Friday 6 October 2017 at 12.45 hours

by

Navessa Padma Tania

born on 12 April 1986 in Bandung, Indonesia

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Supervisors Prof. R. Gosens Prof. M. Schmidt Co-supervisor Dr. H. Maarsingh Assessment Committee Prof. G. Folkerts Prof. C. Bingle Prof. F.A.E. Kruyt

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De rol van BMP/Follistatin-like 1 in

de ontwikkeling en de pathologie van de long

door

Navessa Padma Tania

geboren op 12 april 1986 te Bandung, Indonesië

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

vrijdag 6 oktober 2017 om 12.45 uur

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Paranymphs:

Christel Seegers Thea van den Bosch

The research described in this thesis was carried out at the Department of Molecular Pharmacology (Groningen Research Institute of Pharmacy, University of Groningen, The Netherlands) according to the requirements of the Graduate School of Science (Faculty of Science and Engineering, University of Groningen, The Netherlands).

The research was financially supported by the Lung Foundation Netherlands (grant 3.2.12.083).

Printing of this thesis was financially supported by the University Library of the University of Groningen, the Graduate School of Science, and the Lung Foundation Netherlands.

Cover story: COPD lung vs. developing lung– Putri Astri Wulandari Printing: Ipskamp Printing B.V., Enschede, the Netherlands

ISBN (printed version): 978-94-034-0016-7 ISBN (electronic version): 978-94-034-0015-0

Copyright © 2017 by Navessa Padma Tania. All rights reserved. No parts of this thesis may be reproduced or transmitted in any form or by any means without the prior permission from the author.

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Science knows no country, because knowledge belongs to humanity,

and is the torch which illuminates the world – Louis Pasteur

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1

DEVELOPMENTAL AND PATHOLOGICAL ROLES OF BMP/FOLLISTATIN-LIKE 1

IN THE LUNG

Chapter 1. General Introduction. Chapter 2. Endothelial follistatin-like-1 regulates the postnatal development of the pulmonary vasculature by modulating BMP/Smad signaling. Pulm Circ. 2017; 7(1):219-231 Chapter 3. The effect of cigarette smoking on pulmonary Follistatin-like 1 expres-sion: potential implication in chronic obstructive pulmonary disease Chapter 4. Activin-A: active in inflammation in COPD. EurRespir J. 2014; 43: 954–955 Chapter 5. Pro-inflammatory roles of Follistatin-like 1 in coordinating epitheli-al-mesenchymal communication in inflammatory cytokine release in the lung Submitted Chapter 6. Regulation of pulmonary inflammation by mesenchymal cells. Pulm.Pharmacol.Ther. 2014; 1-10 Chapter 7. Variant club cell differentiation is driven by bone morphogenetic protein 4 in adult human airway epithelium: Implications for goblet cell metapla-sia and basal cell hyperplasia in COPD. Chapter 8. General discussion and summary. Chapter 9. Dutch summary/Nederlandse samenvatting Chapter 10. Indonesian summary/Rangkuman dalam bahasa Indonesia Acknowledgement Biography and list of publications

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