University of Groningen
Control of nanopore formation using external triggers Mutter, Natalie
DOI:
10.33612/diss.131163011
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Mutter, N. (2020). Control of nanopore formation using external triggers. University of Groningen. https://doi.org/10.33612/diss.131163011
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Propositions
Associated with the PhD thesis
Control of nanopore formation using external triggers
Natalie Lisa Mutter
1) Die magische Kugel - Wir müssen chemisch Zielen lernen. (Paul Ehrlich) The magic bullet - We have to learn how to aim chemically. (Paul Ehrlich)
2) Pore-forming toxins are naturally virulence factors with versatile applications such as in drug development or in single-molecule analysis. (Chapter 1)
3) Conjugation of cell-binding elements to a toxin increases its specificity toward target cells. (Chapter 2)
4) Borrowing from nature, FraC was synthesized as protoxin to completely suppress off-target toxicity. (Chapter 2)
5) Attachment of azobenzenes to FraC results in reversible and spatiotemporal control of pore assembly by light. (Chapter 3)
6) Pore-forming toxins can be adapted as screening platform for directed evolution experiments to develop proteins with desired properties. (Chapter 4)
7) Evolving AsLOV2 domains responding selectively to a higher wavelength light might improve its use in optogenetics and will allow multiplexing. (Chapter 4)
8) Zwei Dinge sind zu unserer Arbeit nötig: Unermüdliche Ausdauer und die Bereitschaft, etwas, in das man viel Zeit und Arbeit gesteckt hat, wieder wegzuwerfen. (Albert Einstein)
Two things are necessary in our work: tireless endurance and the willingness to throw away something in which one has put a lot of time and efforts. (Albert Einstein)
9) All we have to do is to decide what to do with the time that is given to us. (J.RR. Tolkien) 10) The horse is a mirror to your soul, and sometimes you might not like what you see.
