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Regulation of inflammation by histone deacetylases in rheumatoid arthritis:
beyond epigenetics
Grabiec, A.M.
Publication date
2012
Link to publication
Citation for published version (APA):
Grabiec, A. M. (2012). Regulation of inflammation by histone deacetylases in rheumatoid
arthritis: beyond epigenetics.
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CONTENTS
Chapter 1 Scope of this thesis. 7
Chapter 2 Epigenetics of rheumatoid arthritis. 13
Chapter 3 Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on? 31
Chapter 4 Relationships between protein acetylation in rheumatoid arthritis
synovial tissue and clinical and molecular parameters of disease activity. 55
Chapter 5 Histone deacetylase inhibitors suppress inflammatory activation
of rheumatoid arthritis patient synovial macrophages and tissue. 75
Chapter 6 Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production
by accelerating mRNA decay. 99
Chapter 7 Transcriptional profiling of rheumatoid arthritis fibroblast-like synoviocytes identifies a subset of genes with AU-rich 3’-UTRs which
are suppressed by HDAC inhibitors via reduction of mRNA stability. 117
Chapter 8 HDAC inhibitors prevent inflammation-mediated inactivation of the Forkhead box class O transcription factor FoxO1 in
rheumatoid arthritis. 139
Chapter 9 General discussion. 159
Appendix English summary 183
Nederlandse samenvatting 187
Streszczenie 191
Curriculum vitae 195
List of publications 197
