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Children with severe acute malnutrition
New diagnostic and treatment strategies
Bartels, R.H.
Publication date
2018
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Citation for published version (APA):
Bartels, R. H. (2018). Children with severe acute malnutrition: New diagnostic and treatment
strategies.
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Children with severe acute malnutrition:
Author: Rosalie Bartels
Cover artwork: Anette Tjaerby (http://anettetjaerby.net/) Cover layout: Alexandre Van Damme
Layout and printed by: Optima Grafische Communicatie, Rotterdam, the Netherlands (www.ogc.nl)
ISBN: 978-94-6361-058-2
Financial support for printing this thesis was kindly provided by the Academic Medical Center, BGP products B.V., Doctors for Malawi, Pfizer B.V. and Yakult Nederland B.V. All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without the written permission of the author.
Children with severe acute malnutrition:
new diagnostic and treatment strategies
ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op donderdag 29 maart 2018, te 10.00 uur
door
Rosalie Henriëtte Bartels geboren te Amsterdam
Promotiecommissie: Promotor(es):
Prof. dr. M. Boele van Hensbroek AMC-Universiteit van Amsterdam
Copromotor(es):
Dr. W.P. Voskuijl AMC- Universiteit van Amsterdam
Dr. R.H.J. Bandsma University of Toronto Overige leden:
Prof. dr. H.S.A. Heymans AMC- Universiteit van Amsterdam
Prof. dr. J.B. van Goudoever AMC- Universiteit van Amsterdam
Prof. dr. M.J. Manary Washington University
Prof. dr. T. Ahmed University of Queensland
Dr. B.G.P. Koot AMC-Universiteit van Amsterdam
Dr. P.F. van Rheenen Rijksuniversiteit Groningen
Despite the hunger we cannot possess more than this: Peace in a garden of our own.
COnTEnTS
Chapter 1 General Introduction and Outline of the Thesis 9 Chapter 2 The relation between malnutrition and the exocrine pancreas:
a systematic review
23
Chapter 3 Both exocrine pancreatic insufficiency and signs of pancreatic inflammation are highly prevalent in children with complicated severe acute malnutrition: an observational study
85
Chapter 4 Pancreatic enzyme replacement therapy in children with severe acute malnutrition: A randomized controlled trial
101
Chapter 5 Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomized controlled 3-arm intervention trial in Malawi
123
Chapter 6 The clinical use of longitudinal bio-electrical impedance analysis in children with severe acute malnutrition
155
Chapter 7 Summary, General Discussion and Conclusions 179
Appendices Nederlandse Samenvatting 195
Abbreviations 211
Contributing Authors 213
Acknowledgements 216
