University of Groningen
Right ventricular adaptation to chronic abnormal loading
Hagdorn, Quint
DOI:
10.33612/diss.135804654
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Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Hagdorn, Q. (2020). Right ventricular adaptation to chronic abnormal loading: and implications for patients
with tetralogy of Fallot. https://doi.org/10.33612/diss.135804654
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Quint A.J. Hagdorn
RIGHT VENTRICULAR ADAPTATION
TO CHRONIC ABNORMAL LOADING
Financial support by the following companies / institutes for the publication of this thesis is gratefully acknowledged:
Chipsoft
Guerbet Nederland Heart Medical
Medis Medical Imaging Systems
Noord Negentig accountants en belastingadviseurs Rijksuniversiteit Groningen
Salveo Medical
Servier Nederland Farma Van der Meer Accountants
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
© Copyright 2020 Quint A.J. Hagdorn
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without permission of the authors and, when appropriate, the publisher holding the copyrights of the published articles.
ISBN 978-94-034-2467-5 (printed version ISBN 978-94-034-2468-2 (electronic version)
Cover design and layout by: Daniëlle Balk, www.persoonlijkproefschrift.nl Printed by: Ridderprint, www.ridderprint.nl
TABLE OF CONTENTS
Introduction
Chapter 1a. General introduction 9
Chapter 1b. Setting the stage for increasing diversity in congenital cardiology: let’s celebrate the 75th anniversary of the Blalock-Thomas-Taussig shunt
Cardiology in the Young 2020
25
Chapter 2. Systematic Review of Volume Load-Induced Right Ventricular Dysfunction in Animal Models: A Translational Gap in Congenital Heart Disease
European Journal of Heart Failure 2018
29
Experimental studies
Chapter 3. A novel method optimizing the normalization of cardiac parameters in small animal models: the importance of dimensional indexing
American Journal of Physiology - Heart and Circulatory Physiology 2019
49
Chapter 4. Volume load-induced right ventricular failure in rats is not associated with myocardial fibrosis
Submitted
61
Chapter 5. Inhibition of the prolyl isomerase Pin1 attenuates vascular remodeling in pulmonary arterial hypertension by inhibiting TGFβ/FOXM1/PLK1 signaling
Submitted
83
Chapter 6. Female sex is protective for clinical heart failure in a juvenile rat model of right ventricular pressure load
Ready for submission
111
Clinical studies
Chapter 7. Risk of cardiac tachyarrhythmia in patients with repaired tetralogy of Fallot: a multicenter cardiac MRI based study
International Journal of Cardiovascular Imaging 2018
127
Chapter 8. Cardiac magnetic resonance left ventricular strain-rate predicts ventricular tachycardia but not deterioration of ventricular function in patients with repaired tetralogy of Fallot
International Journal of Cardiology 2019
145
Chapter 9. Sex differences in patients with repaired tetralogy of Fallot support a tailored approach for males and females: a cardiac magnetic resonance study
International Journal of Cardiovascular Imaging 2020
163
Chapter 10. General discussion 185
Appendices. Dutch summary 200
About the author 204
