University of Groningen
Right ventricular adaptation
Koop, Anne-Marie
DOI:
10.33612/diss.144160773
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Publication date:
2020
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Citation for published version (APA):
Koop, A-M. (2020). Right ventricular adaptation: in conditions of increased pressure load. University of
Groningen. https://doi.org/10.33612/diss.144160773
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R I G H T V E N T R I C U L A R
A D A P T A T I O N
in conditions of increased pressure load
Right ventricular adaptation in conditions of increased pressure load PhD thesis, University of Groningen
Author: Anne-Marie Koop
Cover design: Stefan Heinrich & Willemijn Vismans Text lay-out: Stefan Heinrich | www.publiss.nl Printing: Ridderprint | www.ridderprint.nl ISBN (printed book): 978-94-6416-264-6
ISBN (e-book): 978-94-6416-265-3
Financial support for the publication of this thesis was kindly provided by: ABN Amro
Chipsoft
Guerbet Nederland Koop Communicatie
Medis Medical Imaging Systems Pfizer
Rijksuniversiteit Groningen Salveo Medical
Spinalis ergonomische stoelen
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
© Copyright 2020 by Anne-Marie C. Koop
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without permission of the authors.
Right ventricular adaptation
In conditions of increased pressure load
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 25 november 2020 om 09.00 uur
door
Anne-Marie Catherine Koop
geboren op 7 september 1990 te Houten
Promotor
Prof. dr. R.M.F. Berger Dr. H.H.W. SilljéCopromotores
Dr. D.P.Y. Koonen Dr. B. BarteldsBeoordelingscommissie
Prof. dr. F. Kuipers Prof. dr. T. Ebels Prof. dr. H.J. Bogaard7
C O N T E N T
CHAPTER 1 – Introduction.
CHAPTER 2 – Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction. Journal of Molecular and Cellular Cardiology. 2015; 79:244-253.
CHAPTER 3 – Metabolic remodelling in the pressure loaded right ventricle: shifts in glucose and fatty acid metabolism - a systematic review and meta-analysis.
Journal of American Heart Association. 2019; 8.
CHAPTER 4 – Right ventricular pressure overload alters cardiac lipid composition.
International Journal of Cardiology. 2019; 287:96-105.
CHAPTER 5 – Quantification of Biventricular Function and Morphology by Cardiac Magnetic Resonance Imaging in Mice with Pulmonary Artery Banding.
Journal of Visualized Experiments. 2020.
CHAPTER 6 – Increased miR-199b expression contributes to right and left ventricular remodelling in a mouse model of right ventricular pressure overload.
Under revision.
CHAPTER 7 – The adult heart requires baseline expression of the transcription factor Hand2 to withstand RV pressure overload. Under revision.
CHAPTER 8 – Multi-biomarker assessment in children with congenital heart disease and various types of increased right ventricular load.
In preparation.
CHAPTER 9 – General discussion.
APPENDICES
Dutch summary
About the author
Acknowledgements 9 27 63 155 199 225 251 281 307 323 324 329 331
