Immunotolerance during bacterial pneumonia and sepsis - Cover

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Immunotolerance during bacterial pneumonia and sepsis

Hoogerwerf, J.J.

Publication date

2010

Link to publication

Citation for published version (APA):

Hoogerwerf, J. J. (2010). Immunotolerance during bacterial pneumonia and sepsis.

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Immunotolerance during

bacterial pneumonia and sepsis

Immunotolerance during bacterial pneumonia and sepsis

Bacterial pneumonia and sepsis are a major cause of morbidity

and mortality worldwide. Massive use of anti bioti cs promotes

pathogen resistance, and, as a consequence, the incidence

of drug-resistant bacteria is increasing. Therefore, it is of the

utmost importance to expand our comprehension of host

responses against invading pathogens, in order to develop new

treatment strategies. This thesis presents experimental studies

focused on the immune response against bacteria during

(nosocomial) pneumonia and sepsis, and aims to increase our

knowledge of the underlying mechanisms of immunotolerance

as a feature of pati ents with sepsis.

Jacobien Hoogerwerf (The Hague, 1979) received her medical training at the University of Amsterdam (the Netherlands) with additi onal clinical and research courses in South Africa and Kenya. She started her PhD project in 2004 under the supervision of Prof. T. van der Poll at the Center for Experimental and Molecular Medicine. Currently she works as a resident at the Department of Internal Medicine of the Academic Medical Center, Amsterdam, under the guidance of the triumvirate Prof. P. Speelman, Prof. M. Levi and Prof. J.B.L. Hoekstra. In the next years she intends to start training to become an Infecti ous Diseases specialist.

Jacobien Jeltje Hoogerwerf

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Immunot

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