University of Groningen
Comprehensive quality control process for high precision intensity modulated adaptive proton
therapy
Meijers, Artürs
DOI:
10.33612/diss.170751488
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Meijers, A. (2021). Comprehensive quality control process for high precision intensity modulated adaptive proton therapy. University of Groningen. https://doi.org/10.33612/diss.170751488
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1. In the clinical setting, the use of 3% range uncertainty for robust 4DCT and Monte Carlo based treatment planning for thoracic indications is adequate. (this thesis)
2. Anatomical variations show a predominant effect on range accuracy motivating efforts towards the implementation of adaptive radiotherapy. (this thesis)
3. Independent dose recalculation and log file-based Patient Specific Quality Assurance results can be interpreted in clinically relevant manner by using TCP / NTCP. (this thesis)
4. For targets in thoracic region, the interplay effect causes loss of homogeneity for a single fraction, but the loss of homogeneity does not have systematic pattern over multiple fractions and smears out. (this thesis)
5. For targets in thoracic region, anatomical changes throughout the treatment course cause more severe dose degradation than interplay effect. (this thesis)
6. Proton radiography using a range probe provides both the required accuracy to assess and reduce range uncertainty in proton therapy and the simplicity of integrated-mode proton radiography. (Deffet, et al. Medical physics vol. 47(2020): 509-517 )
7. The impact of the interplay effect on the PBS plan robustness is minimal when volumetric
repainting and/or larger spots are employed. (Zeng, et al. Physics in medicine and biology 60 (2015): 3013-29)
8. The log file-based Monte Carlo approach is an end-to-end test incorporating all requirements of patient specific quality assurance. (Winterhalter, et al. Physics in medicine and biology vol. 64 035014. 2019)
9. Due to the fractionated treatment, dose heterogeneities are substantially reduced for the total treatment dose. (Richter, et al. International journal of radiation oncology, biology, physics vol. 89 (2014): 175-81)
