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N-acyl Dopamines - renoprotective therapeutics, acting on TRPV1 signaling: Biological properties and molecular mechanisms

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University of Groningen

N-acyl Dopamines - renoprotective therapeutics, acting on TRPV1 signaling

Pallavi, Prama

DOI:

10.33612/diss.143844258

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Pallavi, P. (2020). N-acyl Dopamines - renoprotective therapeutics, acting on TRPV1 signaling: Biological properties and molecular mechanisms. University of Groningen. https://doi.org/10.33612/diss.143844258

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Proposition belonging to the PhD thesis

N-acyl Dopamines - renoprotective therapeutics, acting on TRPV1 signaling Biological properties and molecular mechanisms

Prama Pallavi

1) The reno-protective properties of NOD, in the context of ischemic acute kidney injury are mediated via TRPV1. - This thesis chapter 3

2) NOD treatment of recipients that received a cold stored renal allograft show no benefit on early renal function - This thesis chapter 3

3) The in vitro bioactivity of NOD is attributed to TRPV1 agonism and its redox active nature. - This thesis chapter 4, chapter 6

4) NOD and capsaicin interact with the same amino acids (T550 and E570) in the binding pocket of TRPV1. - This thesis chapter 4

5) All the structural components of NOD viz- aromatic, linker and side chain regions of NOD are all essential for TRPV1 activation. - This thesis chapter 4

6) NOD exhibits a fast blood clearance and is predominantly eliminated by the liver and kidney. - This thesis chapter 5

7) The in vitro biological properties of a compound are not always replicated in in vivo models. - This thesis chapter 3 and chapter 6

8) Before using a newly synthesized compound always check the purity and its structure via NMR and HPLC. - This thesis

9) Success is stumbling from failure to failure with no loss of enthusiasm. - Winston Churchill 10) Remain calm, serene, always in command of yourself. You will then find out how easy it is to

get along. - Paramahansa Yogananda

11) One who performs duty without ego, with great determination and enthusiasm, and without wavering in success or failure is said to be a worker of the highest caliber. - Bhagavad Gita 18.26

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