• No results found

Metabolomics data complemented drug use information in epidemiological databases: pilot study of potential kidney donors

N/A
N/A
Protected

Academic year: 2021

Share "Metabolomics data complemented drug use information in epidemiological databases: pilot study of potential kidney donors"

Copied!
8
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

Metabolomics data complemented drug use information in epidemiological databases

Klont, Frank; Kremer, Daan; Neto, Antonio W Gomes; Berger, Stefan P; Touw, Daan J; Hak,

Eelko; Bonner, Ron; Bakker, Stephan J L; Hopfgartner, Gérard

Published in:

Journal of Clinical Epidemiology DOI:

10.1016/j.jclinepi.2021.02.008

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Klont, F., Kremer, D., Neto, A. W. G., Berger, S. P., Touw, D. J., Hak, E., Bonner, R., Bakker, S. J. L., & Hopfgartner, G. (2021). Metabolomics data complemented drug use information in epidemiological databases: pilot study of potential kidney donors. Journal of Clinical Epidemiology, 135, 10-16. https://doi.org/10.1016/j.jclinepi.2021.02.008

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

0123456ÿ18ÿ964 56ÿ 161ÿÿÿÿ

 !"

ÿ

!#$"%

ÿ

&'

5(16

1

)

ÿ

5'

5

ÿ

1 6

4'



ÿ

3

2

ÿ

2)

ÿ

48

13

5'

14

ÿ

4

ÿ





16

1

56

ÿ

5'

5(5))*

ÿ

6

1'

ÿ

)'

2

ÿ

18

ÿ

1'

4'

56

ÿ

+

4

ÿ

1413

)

ÿ

,3

54+

ÿ

-6

14'

ÿ5ÿ

.

ÿ

/554

ÿ

-3

3

ÿ(

.

ÿÿ

04'

14

1

ÿ

12

ÿ

31)

ÿ

4'

1

ÿ(

.

ÿÿ

5'

8

54

ÿ

62

ÿ

73

3

ÿ(

.

ÿÿ

/554

ÿ

02

ÿ

8129

ÿ

.

ÿÿ

6

+1

ÿ

:5+

ÿ

.

ÿÿ

;14

ÿ

71443

ÿ

.

ÿÿ

5'

 <54

ÿ

02

=2

ÿ

75++3

ÿ(

.

ÿÿ

3>3

53



ÿ

:1 8

53

'

43

ÿ5.ÿÿ?

5ÿ@ABCÿDEACFECGÿHIGGÿDJCEKLMNCKLOPÿQCJILKNCFKÿMBÿRFMLSIFAEÿIFTÿUFIVOKAEIVÿWXCNAGKLOPÿYFAZCLGAKOÿMBÿ[CFCZIPÿ\]IAÿ^LFCGKÿUFGCLNCKÿ_`Pÿa_aaÿ[CFCZIPÿ DbAKcCLVIFTÿ

(ÿQAZAGAMFÿMBÿdCJXLMVMSOPÿQCJILKNCFKÿMBÿRFKCLFIVÿHCTAEAFCPÿYFAZCLGAKOÿHCTAEIVÿWCFKCLÿ[LMFAFSCFPÿYFAZCLGAKOÿMBÿ[LMFAFSCFPÿeIFcCJVCAFÿaPÿfghhÿijÿ [LMFAFSCFPÿkXCÿdCKXCLVIFTGÿ

ÿQCJILKNCFKÿMBÿWVAFAEIVÿlXILNIEOÿIFTÿlXILNIEMVMSOPÿYFAZCLGAKOÿHCTAEIVÿWCFKCLÿ[LMFAFSCFPÿYFAZCLGAKOÿMBÿ[LMFAFSCFPÿeIFcCJVCAFÿaPÿfghhÿijÿ [LMFAFSCFPÿkXCÿdCKXCLVIFTGÿ

ÿYFAKÿMBÿlXILNIEMkXCLIJOPÿm^JATCNAMVMSOÿnÿm^EMFMNAEGPÿ[LMFAFSCFÿiCGCILEXÿRFGKAK]KCÿMBÿlXILNIEOPÿYFAZCLGAKOÿMBÿ[LMFAFSCFPÿUFKMFA]GÿQC]GAFSVIIFÿ aPÿfgaoÿUpÿ[LMFAFSCFPÿkXCÿdCKXCLVIFTGÿ

ÿiMFÿjMFFCLÿWMFG]VKAFSPÿdCbNILqCKPÿrFKILAMPÿ@osÿoWgPÿWIFITIÿ 0  'ÿÿ,(3253ÿtÿ0u565(6ÿ1464ÿvÿ,(3253ÿÿ

!wxyz{|yÿ

w}~|y€~ÿ8<ÿ1(‚ 'uÿ18ÿ'<)ÿ)'2ÿ95)ÿ'1ÿ4u)'5'ÿ9<'<3ÿ 64 56ÿ'5(161 ).ÿ9< <ÿ)ÿ4 35)46ÿ5 6ÿ4ÿ 1 265'14ƒÿ

(5)ÿ54ÿ 161 56ÿ)'2).ÿ 54ÿ(ÿ2)ÿ'1ÿ 31uÿ5456' 56ÿu4 ÿ18ÿ„ 1)23).ÿ54ÿ9<'<3ÿ)2 <ÿ48135'14ÿ 54ÿ(ÿ2)826ÿ

'1ÿ)'34'<4ÿ54…13ÿ 1 64'ÿ 133) 144ÿ 64 56ÿ5'5(5)ÿ4'3).ÿ'5+4ÿ32ÿ2)ÿ5)ÿ54ÿ„5 62ÿ

†y‡ˆ‰ÿˆ~xŠ‹ÿ{‹ˆÿx~yy‹Šÿ=Œ2ÿ <315'135 <ƒ5))ÿ)  '31'3ÿ=9ƒ&5ÿ'5(161 )ÿ5456))ÿ93ÿ 3813ÿ14ÿ234ÿ

831ÿÿ35416ƒ)6 'ÿ 14'316ÿ)2(‚ ')ÿÿ856)ÿ831ÿ'<ÿ8354) 654'=4)ÿ,11ÿ54ÿ42'3'14ÿ71(54+ÿ54ÿ91<13'ÿ5'2ÿ

498ÿ4'Ž3ÿ498‘.ÿ54ÿ32)ÿ93ÿ4'Žÿ'<312<ÿ)  '356ÿ6(353ÿ)53 <4ÿ54ÿ'53'ÿ)456ÿ„'35 '142ÿ

~x‡’yxÿ“4ÿÿ)2(‚ ')ÿ813ÿ9<1ÿ32ÿ2)ÿ48135'14ÿ95)ÿ5u565(6.ÿÿ„  'ÿ54ÿÿ24„  'ÿ 3) 3 '14ƒ146ÿ32)ÿ93ÿ

4'Ž.ÿ9<6ÿÿ„  'ÿ 3) 3 '14ƒ146ÿ32)ÿ354ÿ24' '2ÿ“4ÿ5'14.ÿ”ÿ 3) 3 '14ƒ146ÿ32)ÿ93ÿ8124ÿ4ÿ”ÿ

)2(‚ ')ÿ813ÿ9<1ÿ32ÿ2)ÿ48135'14ÿ95)ÿ245u565(6.ÿ54ÿÿ1u3ƒ'<ƒ 124'3ÿ32)ÿ93ÿ4'Žÿ4ÿ566ÿÿ)2(‚ ')2ÿ

$•‹|’‡x•‹ÿ&16 2653ÿu4 ÿ813ÿ54ÿ32)ÿ 126ÿ(ÿ3'3uÿ831ÿ=9ƒ&5ÿ'5(161 )ÿ5'5.ÿ9< <ÿ 126ÿ(ÿ2)826ÿ

'1ÿ 1 64'ÿ54ÿ)'34'<4ÿ 161 56ÿ5'5(5))ÿu4ÿ'<5'ÿ 14)35(6ÿ) 3 54 )ÿ93ÿ8124ÿ('94ÿ5456' 566ƒÿ 4'Žÿ32)ÿ54ÿ32)ÿ6)'ÿ4ÿ'<ÿ5u565(6ÿ 64 56ÿ5'5(5)2ÿ – ÿ8<ÿ02'<13)2ÿ62(6)<ÿ(ÿ 6)u3ÿ“4 2ÿ 8<)ÿ)ÿ54ÿ1 4ÿ5 ))ÿ53' 6ÿ243ÿ'<ÿ99ÿ7—ÿ6 4)ÿÿ<'' *…… 35'u 114)213…6 4))…(…˜2…ÿÿ ™CObMLTGšÿ/5'5(5)tÿ/32)tÿ 161tÿ&'5(161 )tÿ› )ÿ / 6535'14ÿ18ÿ91 '4ÿ“4'3)'*ÿ4142ÿ ,244*ÿ,2-2ÿ95)ÿ824ÿ(ÿ'<ÿ 231 54ÿœ414‘)ÿ:1314ÿÿ3)53 <ÿ54ÿ441u5'14ÿ 3135ÿ243ÿ'<ÿ&53ÿ5+ž119)+5ƒ923ÿ354'ÿ534'ÿ 412ÿ”2ÿ8<)ÿ8244ÿ)123 ÿ<5ÿ41ÿ316ÿ4ÿ'<ÿ)4ÿ18ÿ'<)ÿ3u9.ÿ')ÿ„ 2'14.ÿ5456)).ÿ4'3 3'5'14ÿ18ÿ'<ÿ5'5.ÿ13ÿ'<ÿ )14ÿ'1ÿ)2('ÿ 3)26')2ÿ /5'5ÿ)<534ÿ54ÿ5'5ÿ5 ))(6'*ÿ8<ÿ5'5ÿ24364ÿ'<)ÿ53' 6ÿ53ÿ5u565(6ÿ4ÿ'<ÿ—53'5ÿ3)53 <ÿ5'5ÿ3 1)'13.ÿ5'ÿ<'' )*……ÿ„21213…ÿ2”…ÿ 53'5*˜ ' 585(+65”Œ+u'u+2ÿ Ÿ9133) 144ÿ52'<13*ÿ862*ÿ ˜ÿÿ”v˜˜2ÿ,5„*ÿ ˜ÿÿ”vv2ÿ ^mNIAVÿITTLCGGšÿ3532<1 853'43¡242 <ÿ32ÿ:1 853'432ÿ <'' )*……1213…2…‚2‚ 64 222ÿ vƒ˜…– ÿ8<ÿ02'<13)2ÿ62(6)<ÿ(ÿ 6)u3ÿ“4 2ÿ8<)ÿ)ÿ54ÿ1 4ÿ5 ))ÿ53' 6ÿ243ÿ'<ÿ99ÿ7—ÿ6 4)ÿ ÿ<'' *…… 35'u 114)213…6 4))…(…˜2…ÿÿ

(3)

01ÿ34567ÿ87ÿ941ÿÿ 5 694ÿ5ÿ4694ÿ8545ÿÿÿ ÿ !!ÿ

"#$%

ÿ

&

'

ÿ

()*+

ÿ ,)-ÿ.(/&(0'ÿ

1ÿ23456789:;<8ÿ765=98>:4=685ÿ?898ÿ@3A47ÿ;8B?884ÿ 79AC5ÿ6784B6D87ÿ@93EÿE8B:;3<3E6=5ÿ7:B:ÿ:47ÿ79AC5ÿ BF:Bÿ?898ÿ8G>8=B87ÿ;:587ÿ34ÿ64@39E:B634ÿ>98584Bÿ64ÿ BF8ÿ:H:6<:;<8ÿ=<646=:<ÿ7:B:;:58Iÿ

"#$%ÿ%#&'ÿ$//'ÿ%Jÿ*#$%ÿ&'ÿK(J*(+ÿ

1ÿLBA7M64Cÿ<6@85BM<8Nÿ:47ÿ8G>35A98N98<:B87ÿ@:=B395Oÿ ?F6=Fÿ:98ÿ@98PA84B<Mÿ:5585587ÿ;:587ÿ34ÿ64@39E:B634ÿ 98B968H87ÿBF93ACFÿ:4:E48565ÿ:47ÿPA85B6344:6985OÿA5Nÿ 64CÿE398ÿ3;Q8=B6H8ÿ9858:9=FÿE8BF373<3C685ÿ<6R8ÿ =<646=:<ÿE8B:;3<3E6=5ÿE:Mÿ987A=8ÿ;6:5ÿ64ÿ=3998Nÿ 5>34764Cÿ8>678E63<3C6=:<ÿ5BA7685Iÿ

"#$%ÿ&'ÿ%#)ÿ&STU&V$%&J(ÿ$(/ÿ*#$%ÿ'#JWU/ÿV#$(0)ÿ (J*+ÿ

1ÿ2<646=:<ÿE8B:;3<3E6=5Oÿ?F6=Fÿ65ÿ;8=3E64Cÿ=3ENÿ E34><:=8ÿ64ÿ>3>A<:B634N;:587ÿ5BA7685Oÿ5F3A<7ÿ43Bÿ 34<Mÿ;8ÿ:>><687ÿB3ÿ5BA7Mÿ8473C843A5ÿ=3E>3A475ÿ ?6BFÿBF8ÿ:6Eÿ3@ÿ8<A=67:B64Cÿ7658:58ÿE8=F:465E5ÿ:47ÿ 765=3H8964Cÿ76:C435B6=ÿ39ÿ>93C435B6=ÿ;63E:9R895Oÿ:5ÿ BF8ÿ5:E8ÿE8B:;3<3E6=5ÿ7:B:58B5ÿ=:4ÿ:<53ÿ;8ÿA587ÿB3ÿ 5BA7Mÿ8G3C843A5ÿ=3E>3A475ÿ:47ÿBF898;MÿE:Mÿ>93Nÿ H678ÿE3<8=A<:9ÿ8H6784=8ÿ3@ÿ<6@85BM<8Nÿ:47ÿ8G>35A98Nÿ 98<:B87ÿ@:=B395ÿ5A=Fÿ:5ÿ79ACÿA58Iÿ

XYÿZ(%[J/WV%&J(ÿ

\>678E63<3CMÿF:5ÿ;884ÿ:4ÿ6E>39B:4BÿD8<7ÿ3@ÿ9858:9=Fÿ 64ÿF8:<BFÿ5=684=85ÿ@39ÿ78=:785ÿ]!ÿOÿ^_ÿIÿ\>678E63<3C6=:<ÿ5BA7Nÿ 685ÿE35B<Mÿ98<Mÿ34ÿ7:B:ÿ3;B:6487ÿBF93ACFÿ:4:E48565OÿPA85Nÿ B6344:6985Oÿ:47ÿ;:56=ÿE8:5A98E84B5ÿ`ÿ8aÿ:4BF93>3E8B96=ÿ>:Nÿ 9:E8B895Oÿ<:;39:B39MÿE:9R895bOÿ:47ÿ:<53OÿE398ÿ98=84B<MOÿ34ÿ =3E><8Gÿ7:B:ÿ3;B:6487ÿA564Cÿc3E6=5dB8=F43<3C685ÿ]eNf_ÿIÿ

gE6=5ÿB8=F43<3C685ÿ:6EÿB3ÿ>93H678ÿ=3E>98F8456H8ÿ A47895B:4764Cÿ3@ÿ;63<3C6=:<ÿ5M5B8E5Oÿ@39ÿ8G:E><8ÿ;Mÿ 5BA7M64Cÿc5B3987d C848B6=ÿ64@39E:B634ÿ`ÿ8aÿC843E6=5bÿ :47ÿcB9:45=96;87d `ÿ8aÿB9:45=96>B3E6=5bÿ39ÿcB9:45<:B87d C848B6=ÿ64@39E:B634ÿ`ÿ8aÿ>93B83E6=5bÿ]eÿOÿh_ÿIÿi398ÿ@A4=B634:<ÿ A47895B:4764Cÿ=:4ÿ;8ÿ3;B:6487ÿ;Mÿ5BA7M64Cÿ<3?NE3<8=A<:9Nÿ ?86CFBÿ=3E>3A475ÿ`ÿ8aÿE8B:;3<3E6=5bOÿ?F6=FÿE:Mÿ98j8=Bÿ ;63<3C6=:<ÿ=F:4C85ÿ7A8ÿB3ÿC848B6=ÿ:47ÿ84H6934E84B:<ÿ @:=B395OÿA564Cÿ:4:<MB6=:<ÿB8=F46PA85ÿ5A=Fÿ:5ÿ4A=<8:9ÿ E:C48B6=ÿ98534:4=8ÿ`kilbÿ5>8=B935=3>Mÿ:47ÿ<6PA67ÿ =F93E:B3C9:>FMNE:55ÿ5>8=B93E8B9Mÿ`m2NiLbÿ]n_ÿIÿ

o9CA:;<MÿBF8ÿB89EÿE8B:;3<3E6=5ÿ65ÿE65<8:764Cÿ;8=:A58ÿ E8B:;3<3E6=5ÿ?39Rj3?5ÿE8:5A98ÿ43Bÿ34<MÿE8B:;3<6=ÿ >98=A95395Oÿ64B89E876:B85Oÿ:47ÿ847ÿ>937A=B5Oÿ;ABÿ:<53ÿ =3E>3A475ÿBF:Bÿ73ÿ43BÿA4789C3ÿE8B:;3<65EIÿi3983H89Oÿ ?F6<8ÿBF8ÿB89EÿE8B:;3<3E6=5ÿE:Mÿ64BA6B6H8<Mÿ98@89ÿB3ÿ 8473C843A5ÿ=3E>3A475ÿ`ÿ8aÿ:E643ÿ:=675Oÿ=:9;3FM79:B85Oÿ @:BBMÿ:=675bOÿ8G3C843A5ÿ=3E>3A475ÿ`ÿ8aÿ79AC5Oÿ@337ÿ

=345B6BA84B5Oÿ>85B6=6785OÿB3G6=:4B5OÿH6B:E645bÿ:98ÿ3@B84ÿ =3N:4:<M587ÿ?6BF64ÿBF8ÿ5:E8ÿ:4:<M585ÿ]pÿOÿq_ÿIÿi8B:;3<3E6=5ÿ :4:<M585ÿE:MÿBF898;MÿM68<7ÿ:4:<MB6=:<ÿ64@39E:B634ÿ34ÿ <6@85BM<8Nÿ:47ÿ8G>35A98N98<:B87ÿ@:=B395ÿ?F6=Fÿ:98ÿ@98Nÿ PA84B<Mÿ:77985587ÿ64ÿ8>678E63<3C6=:<ÿ5BA7685Oÿ:<;86Bÿ;:587ÿ 34ÿ9:BF89ÿ5A;Q8=B6H8ÿ64@39E:B634ÿ98B968H87ÿH6:ÿPA85B634Nÿ 4:6985ÿ]!rÿOÿ!!_ÿIÿo7E6BB87<MOÿPA85B6344:6985ÿ?6<<ÿ<6R8<Mÿ 98E:64ÿ6E>39B:4Bÿ@39ÿ;A6<764Cÿ8>678E63<3C6=:<ÿ7:B:;:585ÿ 64ÿ@ABA98ÿ5BA7685OÿM8BÿE8B:;3<3E6=5ÿ7:B:ÿ?F6=Fÿ:98ÿ;8Nÿ =3E64Cÿ64=98:564C<Mÿ:H:6<:;<8ÿ64ÿ8>678E63<3C6=:<ÿ5BA7685ÿ

]eÿOÿhÿOÿf_ÿOÿ=3A<7ÿF8<>ÿ=3E><8E84Bÿ:47ÿ5B984CBF84ÿ5>8=6D=ÿ PA85B6344:698N78>84784Bÿ7:B:;:58ÿ84B9685Iÿ

s4ÿBF65ÿ5BA7MOÿ?8ÿ8H:<A:B8ÿ:47ÿ8G><398ÿ7:B:ÿ>93=85564Cÿ 5B9:B8C685ÿ@39ÿ6784B6@M64Cÿ79AC5ÿ64ÿA964:9MOÿm2NiLN;:587ÿ E8B:;3<3E6=5ÿ7:B:Oÿ:47ÿ=3A><8ÿ5A=FÿE3<8=A<:9ÿ8H6784=8ÿ B3ÿ79ACÿA58ÿ64@39E:B634ÿ>98584Bÿ64ÿ:4ÿ8>678E63<3C6=:<ÿ 7:B:;:58ÿ?6BFÿBF8ÿ:6Eÿ3@ÿ5B984CBF8464Cÿ:47t39ÿ=3E><8E84BNÿ 64Cÿ=39985>34764Cÿ7:B:;:58ÿ84B9685Iÿi:4Mÿ<3?NE3<8=A<:9Nÿ ?86CFBÿ79AC5ÿ:98ÿ8G>8=B87ÿB3ÿ;8ÿ78B8=B:;<8ÿ?6BFÿF6CFÿ=34DNÿ 784=8ÿ?F898:5ÿBF8ÿ=34D784=8ÿ3@ÿBF8ÿ58<@N98>39B87ÿ7:B:;:58ÿ 84B9685ÿ65ÿ8G>8=B87ÿB3ÿ;8ÿ<3?89IÿuFA5Oÿ?8ÿFM>3BF856v8ÿBF:Bÿ `!bÿBF898ÿ?6<<ÿ;8ÿ765=98>:4=685ÿ;8B?884ÿ79AC5ÿ6784B6D87ÿ BF93ACFÿE8B:;3<3E6=5ÿB8=F46PA85ÿ:47ÿBF358ÿ<65B87ÿ64ÿBF8ÿ =<646=:<ÿ7:B:;:58ÿ:47ÿBF:Bÿ`^bÿE3<8=A<:9ÿ8H6784=8ÿ3@ÿ79ACÿ A58ÿ98B968H87ÿ@93EÿE8B:;3<3E6=5ÿ7:B:ÿE:Mÿ=3E><8E84Bÿ :47ÿ5B984CBF84ÿ8>678E63<3C6=:<ÿ7:B:;:585Iÿ

wYÿx)%#J/'ÿ

11ÿy7 ÿz5 49756ÿ96ÿy948ÿy848756ÿ

{AE:4ÿA9648ÿ5:E><85ÿ?898ÿ3;B:6487ÿ@93EÿBF8ÿ=34B93<ÿ :9Eÿ`ÿ8aÿ>3B84B6:<ÿR6748Mÿ734395bÿ3@ÿBF8ÿu9:45><:4Bm6485ÿ |337ÿ:47ÿkAB96B634ÿ}63;:4Rÿ:47ÿ23F39BÿLBA7Mÿ`uGmN|k~ÿ k2uÿ6784B6D89ÿk2ur^p!!pe€bÿ]!^_ÿIÿ‚96BB84ÿ64@39E87ÿ =34584Bÿ?:5ÿ3;B:6487ÿ@93Eÿ:<<ÿ5A;Q8=B5OÿE876=:<ÿ8BF6=:<ÿ :>>93H:<ÿ?:5ÿC9:4B87ÿ;MÿBF8ÿ645B6BAB634:<ÿ98H68?ÿ;3:97ÿ3@ÿ BF8ÿƒ46H8956BMÿi876=:<ÿ284B89ÿ„93464C84ÿ`ƒi2„~ÿ78=6Nÿ 5634ÿi\u=ÿ^rrpt!pfbOÿ:47ÿBF8ÿ5BA7Mÿ:7F8985ÿB3ÿBF8ÿ…8=Nÿ <:9:B634ÿ3@ÿ{8<564R6Iÿg48ÿFA47987ÿ5A;Q8=B5ÿ`ee†bÿ?F3ÿF:7ÿ ;884ÿ5=988487ÿ:5ÿ>3B84B6:<ÿR6748Mÿ734395ÿ:BÿBF8ÿƒi2„ÿ ;8B?884ÿg=B3;89ÿ^rrpÿ:47ÿ‡:4A:9Mÿ^r!^ÿ?898ÿ64=<A787ÿ64ÿ BF65ÿ5BA7Mÿ;Mÿ58<8=B634ÿ3@ÿ8PA:<ÿ4AE;895ÿ3@ÿ@8E:<8ÿ:47ÿ E:<8ÿ5A;Q8=B5ÿBF93ACFÿ56E><8ÿ9:473E6v:B634ÿ`588ÿ|6CIÿ!ÿbIÿ 11ÿy7 ÿˆ948ˆÿ

u?84BMN@3A9NF3A9ÿA9648ÿ?:5ÿ=3<<8=B87ÿ`>89ÿ5B96=Bÿ>93Nÿ B3=3<OÿA4789ÿE6489:<ÿ36<ÿB3ÿ>98H84Bÿ8H:>39:B6H8ÿ<35585bÿ64ÿ }…ÿ‰:=AB:6489ÿ^hNF3A9ÿA9648ÿ=3<<8=B634ÿ=34B:64895Oÿ:47ÿ =F<39F8G67648ÿ?:5ÿ:7787ÿ:5ÿ>98589H:B6H8ÿ:C84BIÿL:E><85ÿ ?898ÿ:<6PA3B87ÿA564Cÿ:4ÿ:AB3E:B87ÿ5M5B8Eÿ:47ÿ5B3987ÿ:BÿNÿ prÿŠ2ÿ:47ÿ:BE35>F896=ÿ>9855A98ÿ@39ÿ:>>93G6E:B8<Mÿ!rÿM8:95ÿ A4B6<ÿ5F6>E84Bÿ`‹ÿÿhpÿF3A95ÿ34ÿ79Mÿ6=8ÿ64ÿ:ÿ58=A96BMN58:<87Oÿ 645A<:B87ÿ;3Gÿ@A<<Mÿ=3E><6:4Bÿ?6BFÿsouoOÿo…lOÿ:47ÿhqÿ

(4)

01ÿ 34ÿ56789ÿ9ÿ 64ÿ ÿ 78 6ÿ7ÿ68 6ÿ767ÿÿ ÿ!"ÿ

#$%&ÿ'&ÿ()*+),*-ÿ./ÿ0ÿ1ÿ2ÿ3456*78ÿ3*9*78,.:ÿ;:<ÿ0ÿ=ÿ2ÿ7.++*3>.:<,:?ÿ5;3*9,:*ÿ7@;+;78*+,38,73Aÿ

BCDÿEFGHIÿJKLMNOPKJÿKQRSTLJUPMNIÿLMVÿLOOKPWUXLJQTYÿ1ÿ XPMJZNÿL[JQKÿNZUOXQMJ\ÿ

44ÿ68 6ÿ9  9 ÿ

CSTTYÿLMPMYXUNQVÿNQTQ]JQVÿ]TUMU]LTÿXQJLVLJLÿ^QKQÿOKP_ÿ `UVQVÿaYÿJZQÿaUPaLMbcNÿVLJLÿ]PMJKPTTQKdÿLMVÿUM]TSVQVÿOL_ÿ KLXQJQKNÿ^QKQÿMPJÿ]PMNUVQKQVÿLNÿeOQKNPMLTÿVLJLfEaLNQVÿ PMÿgFhDÿiKJU]TQÿjE0IÿLMVÿgFhDÿDQ]UJLTÿ1kElIIÿLMVÿZLVÿ QUJZQKÿaQQMÿXQLNSKQVÿEÿmÿZQURZJdÿ^QURZJIÿPKÿnSQKUQVÿEÿmÿ LRQdÿNQWdÿVKSRÿSNQIÿLJÿJZQÿJUXQÿP[ÿNLXOTUMR\ÿ

4o4ÿpqÿr7 97 rs ttÿt979su tÿ 9 u767tÿ

vQJLaPTPXU]NÿLMLTYNQNÿ^QKQÿOQK[PKXQVÿPMÿLÿFUPMQWÿwT_ÿ JUXLJQÿxyyyÿDzÿ{BÿNYNJQXÿ]PSOTQVÿJPÿLÿz]UQWÿHKUOTQHGC| lkyyÿXLNNÿNOQ]JKPXQJQKÿE} 1ydÿ yyyÿKQNPTSJUPMIÿQnSUOOQVÿ ^UJZÿLÿFSPzOKLYÿ~ÿUPMÿNPSK]QÿLMVÿLMÿ€F‚ÿ]LTUaKLMJÿVQ_ÿ TU`QKYÿNYNJQXdÿ^ZU]ZÿQMLaTQVÿLSJPXLJU]ÿNYNJQXÿKQ]LTUaKL_ÿ JUPMÿQ`QKYÿJZKQQÿNLXOTQNÿEÿmÿPM]QÿOQKÿZPSKI\ÿzLXOTQNÿ^QKQÿ JZL^QVÿLJÿ1_kÿƒBdÿLMVÿLTUnSPJNÿ^QKQÿJLbQMÿLMVÿJKLMN[QKKQVÿ JPÿRTLNNÿLSJPNLXOTQKÿ`ULTNÿE„g„…ÿBLJ\ÿ†P\ÿzC1Iÿ^UJZÿRTLNNÿ UMNQKJNÿE„g„…ÿBLJ\ÿ†P\ÿ00yly0IÿLMVÿOTLNJU]ÿ]LONÿE„g„…ÿ BLJ\ÿ†P\ÿy‡yxy0I\ÿHZQNQÿ^QKQÿNJPKQVÿUMÿLÿJZQKXPNJLJJQVÿ LSJPNLXOTQKÿLJÿkƒBdÿ ÿLMVÿ1yÿXU]KPTUJQKNÿP[ÿSKUMQÿ^QKQÿLMLT_ÿ YNQVÿaYÿKQ`QKNQV_OZLNQÿTUnSUVÿ]ZKPXLJPRKLOZYÿ]PSOTQVÿJPÿ ezˆiH‰fFLJLÿ€MVQOQMVQMJÿi]nSUNUJUPMÿEF€iIÿXLNNÿNOQ]_ÿ JKPXQJKYÿUMÿOPNUJU`QÿEz€ÿŠÿIÿLMVÿMQRLJU`QÿEz€_IÿQTQ]JKP_ÿ NOKLYÿUPMU‹LJUPMÿXPVQÿENQQÿzSOOTQXQMJLKYÿHLaTQÿ0ÿ[PKÿLÿ VQJLUTQVÿP`QK`UQ^ÿP[ÿLMLTYJU]LTÿOLKLXQJQKNI\ÿzLXOTQNÿ^QKQÿ LMLTYNQVÿUMÿPMQÿaLJ]ZÿOQKÿUPMU‹LJUPMÿXPVQÿE]PMNJKS]JQVÿ[PT_ÿ TP^UMRÿKQ]PXXQMVLJUPMNÿ[KPXÿ„KPLVZSKNJÿQJÿLT\ÿŒ0xÿIÿUM_ÿ ]TSVUMRÿ]PMVUJUPMUMRÿaTLMbNdÿNYNJQXÿNSUJLaUTUJYÿEzzIÿaTLMbNdÿ OPPTQVÿ]PMVUJUPMUMRÿŽBÿNLXOTQNdÿOPPTQVÿzzÿŽBÿNLXOTQNdÿ LMVÿLÿzzÿNJLMVLKVNÿXUWJSKQ\ÿ

44ÿ 9 ÿ7tt8ÿ

BPXOPSMVNÿ^QKQÿOSJLJU`QTYcÿUVQMJU‘QVÿŒ0jÿdÿmÿ^UJZ_ÿ PSJÿ]ZQXU]LTÿKQ[QKQM]QÿNJLMVLKVNÿaSJÿaLNQVÿSOPMÿNOQ]_ÿ

JKLTÿNUXUTLKUJYÿ^UJZÿOSaTU]’]PXXQK]ULTÿNOQ]JKLTÿTUaKLKUQNdÿ ^UJZÿJZQÿ[KQQTY_L`LUTLaTQÿvz_F€i{ÿNP[J^LKQÿE`QKNUPMÿj\yIÿ

Œ0lÿdÿL[JQKÿ]PM`QKJUMRÿKL^ÿ\^U[[cÿ‘TQNÿJPÿ\La[cÿ‘TQNÿSN_ÿ UMRÿDQU[Y]Nÿi„CÿBPM`QKJQKÿNP[J^LKQÿE`QKNUPMÿ0\xdÿ„SUTVÿ ‡x1“IdÿLMVÿ^UJZÿJZQÿ]PXXQK]ULTÿz]UQWÿvLNJQK”UQ^ÿNP[J_ÿ ^LKQÿE`QKNUPMÿ0\0\0•jj\yIÿSJUTUNUMRÿSM]PM`QKJQVdÿz]UQWÿOKP_ÿ OKUQJLKYÿ\^U[[cÿ‘TQN\ÿvz_F€i{ÿNQLK]ZQNÿ^QKQÿOQK[PKXQVÿ SNUMRÿNOQ]JKLTÿTUaKLKUQNÿOKP`UVQVÿ^UJZUMÿJZQÿNP[J^LKQÿOL]b_ÿ LRQÿEVP^MTPLVQVÿPMÿ†P`QXaQKÿ01dÿ1y0•IdÿMLXQTYÿvzvz_ÿ hSaTU]_hPN_”z01cÿE‡1dx•yÿQMJKUQN…ÿPaJLUMQVÿ^UJZÿVU[[QKQMJÿ vzÿUMNJKSXQMJNÿ[KPXÿVU[[QKQMJÿXLMS[L]JSKQKNÿPOQKLJUMRÿLJÿ `LKYUMRÿ]PTTUNUPMÿQMQKRUQNIÿ[PKÿz€ÿŠÿVLJLÿLMVÿvzvz_ÿ hSaTU]_†QR_”z01cÿEx1d1kxÿQMJKUQN…ÿPaJLUMQVÿ^UJZÿVU[[QKQMJÿ vzÿUMNJKSXQMJNÿ[KPXÿVU[[QKQMJÿXLMS[L]JSKQKNÿPOQKLJUMRÿLJÿ `LKYUMRÿ]PTTUNUPMÿQMQKRUQNIÿ[PKÿz€_ÿVLJLdÿLMVÿLÿOPNUJU`Qÿ UVQMJU‘]LJUPMÿKQnSUKQVÿLÿ]PXaUMQVÿN]PKQÿP[ÿLJÿTQLNJÿ“l–dÿ LNÿKQTUQVÿPMÿL]]SKLJQÿXLNNÿLMVÿvz’vzÿNOQ]JKSXÿNUXU_ÿ TLKUJY\ÿCPKÿvLNJQK”UQ^ÿNQLK]ZQNdÿUVQMJU‘]LJUPMÿ^LNÿ]LKKUQVÿ PSJÿSNUMRÿLÿ]PXXQK]ULTÿ[PKQMNU]ÿvz’vzÿNOQ]JKLTÿTUaKLKYÿ [KPXÿz]UQWÿE`QKNUPMÿ0\0…ÿ0d‡yyÿQMJKUQN…ÿPaJLUMQVÿ^UJZÿz]UQWÿ HKUOTQHGCÿUMNJKSXQMJNÿLJÿLÿ]PTTUNUPMÿQMQKRYÿP[ÿxlÿ”ÿLMVÿ Lÿ]PTTUNUPMÿQMQKRYÿNOKQLVÿP[ÿ0lÿ”IdÿLMVÿLÿOPNUJU`QÿUVQM_ÿ JU‘]LJUPMÿKQnSUKQVÿLÿ]PXaUMQVÿN]PKQÿP[ÿLJÿTQLNJÿ“y–dÿLNÿ KQTUQVÿPMÿL]]SKLJQÿXLNNdÿUNPJPOQÿKLJUPdÿLMVÿvz’vzÿNOQ]_ÿ JKSXÿNUXUTLKUJY\ÿzOQ]U‘]ÿNQJJUMRNÿ[PKÿvz_F€i{ÿLMVÿvLN_ÿ JQK”UQ^ÿNQLK]ZQNÿLKQÿOKP`UVQVÿUMÿzSOOTQXQMJLKYÿHLaTQNÿ1ÿ LMVÿxdÿKQNOQ]JU`QTY\ÿBPXOPSMVÿZUJNÿ^QKQÿQ`LTSLJQVÿaLNQVÿ PMÿNUXUTLKUJYÿ^UJZÿNOQ]JKLTÿTUaKLKUQNÿP[ÿJZQÿKQNUVSLTÿOKQ]SK_ÿ NPKÿLMVÿLJÿTQLNJÿJ^Pÿ[KLRXQMJÿUPMNdÿQW]QOJÿ[PKÿOLKL]QJLXPTÿ [PKÿ^ZU]ZÿPMQÿ[KLRXQMJÿUPMÿ^LNÿLTTP^QVÿLJÿLÿNOQ]U‘]ÿKQ_ÿ JQMJUPMÿJUXQÿJZLJÿ^LNÿ]ZQ]bQVÿSNUMRÿLÿOLKL]QJLXPTÿKQ[QK_ÿ QM]QÿNJLMVLKVÿUM]TSVQVÿUMÿJZQÿzzÿNJLMVLKVNÿXUWJSKQ\ÿ€[ÿLÿ VKSRÿ^LNÿUVQMJU‘QVÿUMÿJ^PÿLV—L]QMJÿNLXOTQNdÿJZQÿNQ]PMVÿ UVQMJU‘]LJUPMÿ^LNÿ˜LRRQVÿLNÿOPNNUaTYÿaQUMRÿ[LTNQÿOPNUJU`Qÿ aQ]LSNQÿMPÿUMVU`UVSLTÿVKSRÿ^LNÿQWOQ]JQVÿUMÿXPKQÿJZLMÿl–ÿ P[ÿJZQÿNSa—Q]JNÿLMVÿaQ]LSNQÿLMYÿNQ]PMVÿUVQMJU‘]LJUPMÿXLYÿ aQÿJZQÿKQNSTJÿP[ÿ]LKKYP`QKÿQ[[Q]JNdÿ^ZU]Zÿ^QKQÿNSaNQnSQMJTYÿ Q`LTSLJQVÿOPNJ_LMLTYNUN\ÿCPKÿLXaURSPSNÿUVQMJU‘]LJUPMNdÿJZQÿ XPNJÿOKPaLaTQÿUVQMJUJYÿ^LNÿKQOPKJQVÿaLNQVÿPMÿL`LUTLaTQÿUM_ÿ [PKXLJUPMÿPMÿVKSRÿSNQÿUMÿJZQÿ]TUMU]LTÿVLJLaLNQÿLMV’PKÿKL_ÿ JUPMLTÿLNNURMXQMJ\ÿCPKÿQWLXOTQdÿLÿOQLbÿ^UJZÿX’‹ÿ1‡‡\0“xÿ

(5)

01ÿ34567ÿ87ÿ941ÿÿ 5 694ÿ5ÿ4694ÿ8545ÿÿÿ ÿ !"ÿ

#$%&ÿ'&ÿ()**ÿ+,-./-01ÿ2/)1)*3,*.ÿ45)/5,)61ÿ47ÿ8ÿ9:;ÿ<ÿ2/)1=/,23,4*>4*?@ÿ+/A.1ÿ-*+ÿ8ÿBÿ<ÿ45)/>3C)>=4A*3)/ÿ+/A.1ÿ6C,=Cÿ6)/)ÿ82A3-3,5)?@ÿDEFGÿ<ÿ,+)*3,H)+ÿ ,*ÿEIIÿCA0-*ÿ1AJK)=31ÿ74/ÿ6C40ÿ,*74/0-3,4*ÿ4*ÿ+/A.ÿA1)ÿ6-1ÿ8ÿ9:Lÿ<ÿ-5-,?-J?)ÿ4/ÿ8ÿ;ÿ<ÿA*-5-,?-J?)ÿ,*ÿ3C)ÿ=?,*,=-?ÿ+-3-J-1)Mÿ

NOPÿNÿQRSROSTUOÿSTVRÿUWÿ!!XYÿVTOXÿZN[ÿVNS\]RPÿSUÿ^US]ÿ NVTSQT_S`aTORÿNOPÿS]RÿVRS]NPUORÿVRSN^UaTSRÿbcddefÿTOÿUORÿ [NV_aRÿ^gSÿZN[ÿN[[ThORPÿSUÿNVTSQT_S`aTORÿN[ÿS]T[ÿPQghÿZN[ÿ aT[SRPÿTOÿS]Rÿ\aTOT\NaÿPNSN^N[RÿWUQÿS]Rÿ\UQQR[_UOPTOhÿ[g^iÿ jR\SXÿkN[Sa`lÿSNQhRSRPÿ[ThONaÿRmSQN\STUOÿZN[ÿ_RQWUQVRPÿg[TOhÿ n\TRmÿeRNopTRZÿ[UWSZNQRÿqrRQ[TUOÿsXsXtX!!"Y!uÿNOPÿn\TRmÿ vgaSTwgNOSÿ[UWSZNQRÿqrRQ[TUOÿsX!uÿZTS]ÿNÿxsXyÿVdNÿVN[[ÿ RmSQN\STUOÿZTOPUZÿNOPÿNÿsXtÿ_UTOSÿzNg[[TNOÿ[VUUS]TOhÿ ZTPS]Xÿ

{|ÿ}~€‚ÿ

11ÿƒ ÿ867„9756ÿ7… 5 …ÿ†87 94ÿ4‡ 9 ÿ†89 …6ÿ ˆWÿ‰"ÿ[g^jR\S[ÿWUQÿZ]UVÿPQghÿg[RÿTOWUQVNSTUOÿZN[ÿ NrNTaN^aRÿTOÿS]Rÿ\aTOT\NaÿPNSN^N[RlÿPQgh[ÿZRQRÿTPROSTŠRPÿ TOÿy‰ÿ[g^jR\S[ÿq‹tŒuÿZ]ROÿTO\agPTOhÿNOPÿ"yÿ[g^jR\S[ÿ qsŒuÿZ]ROÿRm\agPTOhÿ_NQN\RSNVUaÿq[RRÿng__aRVROSNQ`ÿ ŽN^aRÿuXÿPROSTŠ\NSTUO[ÿTO\agPRPÿstÿRm_R\SRPÿ_QR[\QT_STUOiÿ UOa`ÿPQgh[ÿNOPÿsÿS]NSÿZRQRÿOUSÿRm_R\SRPÿ^N[RPÿUOÿTOWUQiÿ VNSTUOÿ_QR[ROSÿTOÿS]Rÿ\aTOT\NaÿPNSN^N[Rÿq[RRÿ‘ThXÿsÿuXÿŽ]TQS`ÿ PQgh[ÿZRQRÿRm_R\SRPÿ^gSÿOUSÿTPROSTŠRPlÿ"ÿUWÿZ]T\]ÿZRQRÿ _QR[\QT^RPÿUOÿNÿbÿ 5ÿ 8ÿ6979ÿqe’“”ÿN[ÿORRPRPufÿ^N[T[lÿNOPÿ‹ÿ US]RQ[ÿTO\agPRPÿaU\Naa`iNPVTOT[SRQRPÿNOPÿiN\STrRÿPQgh[XÿˆWÿ S]RÿUS]RQÿstÿRm_R\SRPÿ^gSÿOUSÿTPROSTŠRPÿPQgh[lÿ[UVRÿNQRÿ

oOUZOÿSUÿ^RÿqNaVU[SuÿWgaa`ÿRm\QRSRPÿ^`ÿS]RÿaTrRQÿNOPÿOUSÿ Rm_R\SRPÿTOÿgQTORÿqÿ8•ÿNSUQrN[SNSTOlÿ[TVrN[SNSTO”ÿÿPNSN^N[Rÿ ROSQTR[ÿTOÿSUSNauÿ–!—ÿ”ÿ[UVRÿNQRÿRmSRO[TrRa`ÿVRSN^UaT[RPÿ^`ÿ S]RÿaTrRQÿ^RWUQRÿQRONaÿRm\QRSTUOÿNOPÿOUSÿRm_R\SRPÿTOÿgQTORÿTOÿ S]RTQÿONSTrRÿWUQVÿqÿ8•ÿUVR_QN˜UaRlÿQN^R_QN˜UaRlÿOTWRPT_TOR”ÿ ‹ÿROSQTR[uÿ–!‹ist—ÿ”ÿ[UVRÿ\NOOUSÿ^RÿPTWWRQROSTNSRPÿWQUVÿNOÿ ROPUhROUg[ÿ]gVNOÿVRSN^UaTSRÿPgRÿSUÿ[SQg\SgQNaÿ[TVTaNQTS`ÿ qÿ8•ÿaRrUS]`QUmTOR”ÿ!ÿROSQ`u”ÿNOPÿUS]RQ[ÿNQRÿSUUÿ[VNaaÿSUÿ ^RÿTPROSTŠRPÿZTS]ÿ[gWŠ\TROSÿ\UOŠPRO\Rÿg[TOhÿS]RÿPR[\QT^RPÿ ZUQo™UZÿqÿ8•ÿWgVNQT\ÿN\TPlÿ^RSN]T[STOR”ÿsÿROSQTR[ulÿZTS]ÿ UORÿqÿ8•ÿ^RSN]T[STORuÿaN\oTOhÿNÿQRWRQRO\Rÿ[_R\SQgVÿTOÿNO`ÿ UWÿS]Rÿ[_R\SQNaÿaT^QNQTR[ÿRV_aU`RPÿTOÿS]T[ÿ[SgP`Xÿ

ˆWÿS]Rÿ!‹ÿ[g^jR\S[ÿWUQÿZ]UVÿPQghÿg[RÿTOWUQVNSTUOÿZN[ÿ gONrNTaN^aRlÿPQgh[ÿZRQRÿTPROSTŠRPÿTOÿ!!ÿ[g^jR\S[ÿqyŒuÿ Z]ROÿTO\agPTOhÿNOPÿÿ[g^jR\S[ÿq"yŒuÿZ]ROÿRm\agPTOhÿ _NQN\RSNVUaÿq[RRÿng__aRVROSNQ`ÿŽN^aRÿuXÿvU[SÿUWÿS]R[Rÿ TO\agPRÿUrRQiS]Ri\UgOSRQÿPQgh[ÿqÿ8•ÿ_NQN\RSNVUalÿT^g_QUiÿ WROlÿON_QUmROuÿNOPÿ_QR[\QT_STUOiUOa`ÿPQgh[ÿTOSROPRPÿWUQÿ []UQSiSRQVÿUQÿe’“ÿg[Rÿqÿ8•ÿ\T_QU™UmN\TOlÿOR_NWRON\lÿ˜U_Tiÿ \aUORulÿZ]TaRÿPQgh[ÿTOSROPRPÿWUQÿaUOhiSRQVÿg[RÿZRQRÿUOa`ÿ WUgOPÿTOÿS]QRRÿ[g^jR\S[ÿqÿ8•ÿWgQU[RVTPRÿTOÿSZUÿ[g^jR\S[ÿ NOPÿ^US]ÿNVTSQT_S`aTORÿNOPÿVRSU_QUaUaÿTOÿS]RÿS]TQPÿ[g^jR\Suÿ q[RRÿ‘ThXÿsÿuXÿ

‘TONaa`lÿy‰ÿUrRQiS]Ri\UgOSRQÿPQgh[ÿZRQRÿTPROSTŠRPÿTOÿysÿ UWÿS]Rÿ!ttÿ[g^jR\S[lÿNOPÿS]R[RÿPQgh[ÿZRQRÿRTS]RQÿNONahR[T\[ÿ

(6)

01ÿ 34ÿ56789ÿ9ÿ 64ÿ ÿ 78 6ÿ7ÿ68 6ÿ767ÿÿ ÿ!"ÿ #ÿ$ÿ%&'()*+,-'.ÿ&/012)*+,.ÿ,-12)3+,.ÿ1-2-'+4-5)(6ÿ77ÿ+,8ÿ

42&+9:.ÿ,-9-(ÿ%+'),;+94-,49ÿ#$ÿ ÿ3<()5+4-=)(&,+6ÿ>ÿ+,42&+9:ÿ )2ÿ-,ÿ-,4&8-((+2;<ÿ%20;ÿ#ÿ$ÿ'+4&2&=&,+6ÿ0ÿ+,42<:ÿ#9++ÿ?&;@ÿ>ÿ:@ÿ A)94ÿ)*ÿ4B+9+ÿ&%+,4&C'-4&),9ÿ&,'(0%+ÿDEFÿ%20;9ÿGB&'Bÿ -2+ÿ2-4B+2ÿB-25(+99ÿ-4ÿ,)25-(ÿ%)9+9.ÿ-(4B)0;Bÿ7ÿ+,42&+9ÿ -2+ÿ,),94+2)&%-(ÿ-,4&8&,H-55-4)2<ÿ%20;9ÿ#FIJKL6ÿ$ÿ%&8ÿ '()*+,-'.ÿ&/012)*+,.ÿ,-12)3+,:ÿGB&'Bÿ')0(%ÿ/+ÿB-25*0(ÿ-4ÿ ,)25-(ÿ%)9+9ÿ*)2ÿ9)5+ÿ;2)019ÿG&4B&,ÿ4B+ÿ1)10(-4&),ÿM>0Nÿ@ÿ 44ÿOÿ89P 978ÿ9Q7Qÿ9 9ÿR8 6ÿS9 978ÿ D2+9'2&14&),8),(<ÿ%20;9ÿ4B-4ÿG+2+ÿ+31+'4+%ÿ/04ÿ,)4ÿ&%+,8ÿ 4&C+%.ÿ-((ÿG&4Bÿ4B+ÿ+3'+14&),ÿ)*ÿ()'-((<8-%5&,&94+2+%ÿ%20;9ÿ #9++ÿ?&;@ÿ>ÿ6ÿTÿ+,42&+9:.ÿ%20;9ÿ&,4+,%+%ÿ*)2ÿ9B)2484+25ÿ)2ÿ DEFÿ09+ÿ#9++ÿ?&;@ÿ>ÿ6ÿUÿ+,42&+9:.ÿ-,%ÿ%20;9ÿ4B-4ÿG+2+ÿ,)4ÿ +31+'4+%ÿ4)ÿ/+ÿ*)0,%ÿ&,ÿ02&,+ÿ%0+ÿ4)ÿ4B+&2ÿ9420'402-(ÿ-,%V)2ÿ %20;ÿ5+4-/)(&95ÿ-,%ÿ1B-25-')W&,+4&'9ÿ#LADX:ÿ12)1+24&+9ÿ #ÿ$ÿ-4)2Y-94-4&,.ÿ/+4-B&94&,+.ÿ*05-2&'ÿ-'&%.ÿ(+Y)4B<2)3&,+.ÿ ,&*+%&1&,+.ÿ9&5Y-94-4&,6ÿZÿ+,42&+9:.ÿG+2+ÿ&,Y+94&;-4+%ÿ*028ÿ 4B+2ÿ01),ÿ&,4+22);-4&,;ÿ5+4-/)()5&'9ÿ%-4-ÿ&,ÿ-ÿ4-2;+4+%ÿ *-9B&),ÿ#9++ÿI011(+5+,4-2<ÿE+90(49ÿ0:@ÿ[B+9+ÿ9+-2'B+9ÿ <&+(%+%ÿ>ÿ-%%&4&),-(ÿ&%+,4&C'-4&),9.ÿ,-5+(<ÿ)5+12-=)(+ÿ&,ÿ 90/\+'4ÿ1]ÿ-,%ÿ)5+12-=)(+ÿ&,ÿ90/\+'4ÿZ0@ÿ^)4Bÿ&%+,4&C'-8ÿ 4&),9ÿG+2+ÿ%+2&Y+%ÿ*2)5ÿ-,-(<4&'-(ÿ9&;,-(9ÿ')22+91),%&,;ÿ 4)ÿ)5+12-=)(+_9ÿ1B-9+ÿKÿ5+4-/)(&4+9ÿ78B<%2)3<)5+12-=)(+ÿ -,%ÿ)5+12-=)(+ÿ90(*),+.ÿGB&'Bÿ/)4Bÿ')0(%ÿ,)4ÿB-Y+ÿ/++,ÿ &%+,4&C+%ÿ4B2)0;Bÿ91+'42-(ÿ(&/2-2<ÿ9+-2'B&,;ÿ%0+ÿ4)ÿ4B+ÿ-/8ÿ 9+,'+ÿ)*ÿ2+*+2+,'+ÿ91+'42-ÿ*)2ÿ4B+9+ÿ')51)0,%9@ÿA)2+8ÿ )Y+2.ÿ4B+ÿ)4B+2ÿ,&,+ÿ%20;9ÿ')0(%ÿ4B+)2+4&'-((<ÿ/+ÿ&%+,4&C+%ÿ 4B2)0;Bÿ4-2;+4+%ÿ9&;,-(ÿ+342-'4&),.ÿ<+4ÿ-112)12&-4+ÿ9&;,-(9ÿ G+2+ÿ-/9+,4@ÿ

J4ÿ(-94.ÿ4-2;+4+%ÿ9&;,-(ÿ+342-'4&),ÿG-9ÿ-(9)ÿ09+%ÿ4)ÿ+Y-(8ÿ 0-4+ÿ4B+ÿ&%+,4&C'-4&),ÿ)*ÿ*02)9+5&%+ÿ&,ÿ90/\+'4ÿ>`ÿGB&'Bÿ G-9ÿ'),9&%+2+%ÿ0,2+(&-/(+ÿ/+'-09+ÿ&4ÿG-9ÿ-(9)ÿ&%+,4&C+%ÿ&,ÿ 4B+ÿ12+'+%&,;ÿ9-51(+ÿ-,%ÿ/+'-09+ÿ-,-(<4&'-(ÿa'-22<)Y+2ÿ+*8ÿ *+'49_ÿ*2)5ÿ),+ÿ9-51(+ÿ4)ÿ4B+ÿ,+34ÿ')0(%ÿ,)4ÿ/+ÿ+3'(0%+%ÿ #9++ÿI011(+5+,4-2<ÿE+90(49ÿ>:@ÿb)22+91),%&,;ÿ12)'+%02+9ÿ &,%&'-4+%ÿ4B-4ÿ'-22<)Y+2ÿ+**+'49ÿ*)2ÿ*02)9+5&%+ÿG+2+ÿ,+;(&8ÿ ;&/(<ÿ95-((ÿ*)2ÿ4B+ÿ-,-(<4&'-(ÿG)2WH)Gÿ+51()<+%ÿ-,%ÿ4B-4ÿ 4B+ÿ*02)9+5&%+ÿ&%+,4&C'-4&),ÿ&,ÿ90/\+'4ÿ>`ÿ')0(%ÿ/+ÿ42+-4+%ÿ -9ÿ-ÿ420+ÿ1)9&4&Y+ÿC,%&,;@ÿ

cdÿefghiggfjkÿ

l02ÿG)2WÿB&;B(&;B49ÿ)11)240,&4&+9ÿ*)2ÿC,%&,;ÿ5)(+'0(-2ÿ +Y&%+,'+ÿ)*ÿ%20;ÿ09+ÿ&,ÿ-ÿ1)10(-4&),8/-9+%ÿ9+44&,;ÿ4B2)0;Bÿ +31()2-4&),ÿ)*ÿmb8AIÿ5+4-/)()5&'9ÿ%-4-ÿ/<ÿ0,4-2;+4+%ÿ 91+'42-(ÿ(&/2-2<ÿ9+-2'B&,;ÿ-,%ÿ4-2;+4+%ÿ9&;,-(ÿ+342-'4&),ÿ 12)'+%02+9@ÿK4ÿ-(9)ÿ0,%+2(&,+9ÿ4B+ÿ2-4&),-(+ÿ*)2ÿC,%&,;ÿ 90'Bÿ+Y&%+,'+ÿ-9ÿG+ÿ2+Y+-(+%ÿ'),9&%+2-/(+ÿ%&9'2+1-,'&+9ÿ /+4G++,ÿ%20;9ÿ&%+,4&C+%ÿ*2)5ÿ5+4-/)()5&'9ÿ%-4-ÿ-,%ÿ %20;9ÿ4B-4ÿG+2+ÿ+31+'4+%ÿ/-9+%ÿ),ÿ&,*)25-4&),ÿ12+9+,4ÿ&,ÿ 4B+ÿ'(&,&'-(ÿ%-4-/-9+ÿ*)2ÿ4B+ÿ02&,+ÿ9-51(+9ÿ940%&+%@ÿI1+'&*8ÿ &'-((<.ÿ&,ÿ`Uÿ90/\+'49.ÿG+ÿ&%+,4&C+%ÿ>>ÿ12+9'2&14&),8),(<ÿ %20;9ÿGB&'BÿG+2+ÿ+31+'4+%ÿ-,%ÿ>nÿ%20;9ÿGB&'BÿG+2+ÿ,)4ÿ +31+'4+%.ÿGB+2+-9ÿ>`ÿ%20;9ÿ(&94+%ÿ&,ÿ4B+ÿ'(&,&'-(ÿ%-4-/-9+ÿ

G+2+ÿ,)4ÿ&%+,4&C+%@ÿJ(9).ÿG+ÿ*)0,%ÿTÿ12+9'2&14&),8),(<ÿ %20;9ÿ&,ÿ0Tÿ90/\+'49ÿ*)2ÿGB)5ÿ&,*)25-4&),ÿ),ÿ%20;ÿ09+ÿ G-9ÿ,)4ÿ-Y-&(-/(+@ÿ

?)2ÿ%20;9ÿ4B-4ÿG+2+ÿ&%+,4&C+%ÿ/04ÿ,)4ÿ+31+'4+%.ÿ&,*)28ÿ 5-4&),ÿ),ÿ%20;ÿ09+ÿ2+42&+Y+%ÿ4B2)0;Bÿ-,-5,+9&9ÿG-9ÿ(&W+(<ÿ &,')51(+4+.ÿGB&'Bÿ&9ÿ-ÿW,)G,ÿ&990+ÿ*)2ÿ9+(*82+1)24+%ÿ%-4-ÿ &,ÿ#1B-25-')8:+1&%+5&)();&'-(ÿ940%&+9ÿM>>Nÿ@ÿI40%<ÿ90/8ÿ \+'49ÿ5&;B4ÿB-Y+ÿ*)2;)44+,ÿ4)ÿ2+1)24ÿ91+'&C'ÿ%20;9ÿ)2ÿB-Y+ÿ *)2;)44+,ÿ4B-4ÿ4B+<ÿ09+%ÿ4B+5.ÿGB&'Bÿ5-<ÿ)''02ÿGB+,ÿ2+8ÿ '+&Y&,;ÿ%20;9ÿ12+89)24+%ÿ/<ÿ%-4+ÿ-,%ÿ4&5+ÿ&,ÿ9-'B+49@ÿK,ÿ-%8ÿ %&4&),.ÿ&4ÿ&9ÿ1)99&/(+ÿ4B-4ÿ90/\+'49ÿG+2+ÿ4-W&,;ÿ%&+4-2<ÿ9018ÿ 1(+5+,49ÿ'),4-&,&,;ÿ0,%+'(-2+%ÿ%20;ÿ90/94-,'+9@ÿ[)ÿ4B&9ÿ 2+;-2%.ÿ4B+ÿo,&4+%ÿI4-4+9ÿ?))%ÿ-,%ÿL20;ÿJ%5&,&942-4&),ÿ #?LJ:ÿ2+'+,4(<ÿ&990+%ÿ9+Y+2-(ÿG-2,&,;9ÿ*)2ÿ%&+4-2<ÿ9018ÿ 1(+5+,49ÿ'),4-5&,-4+%ÿG&4Bÿ%20;9.ÿ&,'(0%&,;ÿ*02)9+5&%+ÿ GB&'Bÿ2+12+9+,4+%ÿ-ÿ'),9&%+2-/(+ÿ12)1)24&),ÿ)*ÿ4B+ÿa&%+,8ÿ 4&C+%ÿ/04ÿ,)4ÿ+31+'4+%_ÿ%20;9ÿ&,ÿ4B+ÿ12+9+,4+%ÿG)2WÿM>UNÿ@ÿ [B+2+ÿ')0(%ÿ/+ÿ9+Y+2-(ÿ+31(-,-4&),9ÿ*)2ÿ+31+'4+%ÿ%20;9ÿ ,)4ÿ/+&,;ÿ&%+,4&C+%.ÿ-,%ÿ4B+9+ÿ5-<ÿ(&,Wÿ4)ÿ-ÿ91+'&C'ÿ 90/\+'4.ÿ4B+ÿ09+ÿ)*ÿ4B+ÿ%20;.ÿ4B+ÿ9420'402+ÿ-,%ÿ5+4-/)(&'ÿ *-4+ÿ)*ÿ4B+ÿ%20;.ÿ-,%V)2ÿ4B+ÿ9+(+'4+%ÿ-,-(<4&'-(ÿG)2WH)G@ÿ ?)2ÿ+3-51(+.ÿ-ÿ2+1)24+%ÿ%20;ÿ5&;B4ÿ,)4ÿ/+ÿ4-W+,ÿ-,<5)2+.ÿ -ÿ90/\+'4ÿ')0(%ÿ/+ÿ,),8')51(&-,4ÿG&4Bÿ&49ÿ42+-45+,4.ÿ)2ÿ -ÿ90/\+'4ÿ5-<ÿB-Y+ÿ-/+22-,4ÿ%20;ÿ5+4-/)(&95ÿ#%0+ÿ4)ÿ ;+,+4&'ÿ1)(<5)21B&959ÿM>1Nÿ:ÿ(+-%&,;ÿ4)ÿ-/9+,4ÿ-,%V)2ÿ 0,+31+'4+%ÿ%20;ÿ5+4-/)(&4+9.ÿGB&'Bÿ-((ÿ2+H+'4ÿ90/\+'48ÿ )2&+,4+%ÿ+31(-,-4&),9@ÿ?024B+25)2+.ÿ9)5+ÿ%20;9ÿ-2+ÿ4-W+,ÿ ),ÿ-,ÿa-9ÿ,++%+%_ÿ/-9&9ÿ-,%ÿ'-,ÿ;+,+2-((<ÿ),(<ÿ/+ÿ%+4+'4+%ÿ GB+,ÿ4-W+,ÿ9B)24(<ÿ/+*)2+ÿ4B+ÿ4&5+ÿ)*ÿ9-51(&,;.ÿGB&'Bÿ 2+12+9+,49ÿ-ÿ%20;ÿ09+82+(-4+%ÿ+31(-,-4&),@ÿJ,ÿ+3-51(+ÿ)*ÿ -ÿ%20;82+(-4+%ÿ+31(-,-4&),ÿ&9ÿ4B-4ÿ9)5+ÿ%20;9ÿ-,%V)2ÿ%20;ÿ 5+4-/)(&4+9ÿ-2+ÿ,)4ÿ+31+'4+%ÿ4)ÿ/+ÿ12+9+,4ÿ&,ÿ-ÿ/&)();8ÿ &'-(ÿ5-42&3ÿ)*ÿ&,4+2+94ÿ#ÿ$ÿ/())%.ÿ02&,+.ÿ*-+'+9:@ÿK,ÿ4B&9ÿ 2+;-2%.ÿ-,-(<9&,;ÿ50(4&1(+ÿ5-42&'+9ÿG)0(%ÿ/+ÿ/+,+C'&-(ÿ -,%ÿB-9ÿ4B+ÿ-%%&4&),-(ÿ/+,+C4ÿ)*ÿ&,'2+-9&,;ÿ4B+ÿ%+14Bÿ)*ÿ -ÿ5+4-/)()5&'9ÿ940%<@ÿ[B+ÿ*-'4ÿ4B-4ÿ9)5+ÿ%20;9ÿ'-,,)4ÿ /+ÿ%+4+'4+%ÿG&4Bÿ90*C'&+,4ÿ91+'&C'&4<ÿ2+12+9+,49ÿ-,)4B+2ÿ %20;82+(-4+%ÿ+31(-,-4&),.ÿ-(/+&4ÿ),+ÿ4B-4ÿ&9ÿ'),9&%+2-/(<ÿ 5)2+ÿ%&*C'0(4ÿ4)ÿ%+-(ÿG&4B@ÿ[B+ÿ%20;ÿ(+Y)4B<2)3&,+.ÿ*)2ÿ +3-51(+.ÿ&9ÿ4B+ÿ5-,0*-'402+%ÿ*)25ÿ)*ÿ4B+ÿ+,%);+,)09ÿ 4B<2)&%ÿB)25),+ÿ[1.ÿ-,%ÿ&4ÿ&9ÿ&51)99&/(+ÿ4)ÿ%&**+2+,4&-4+ÿ 4B+5ÿ-9ÿ4B+<ÿ-2+ÿ9420'402-((<ÿ4B+ÿ9-5+@ÿJÿ9&5&(-2ÿ12)/(+5ÿ -2&9+9ÿ*)2ÿ4B+ÿ-,4&4B2)5/)4&'ÿ%20;ÿ-'+4<(9-(&'<(&'ÿ-'&%ÿ GB&'Bÿ9B-2+9ÿ,+-2(<ÿ-((ÿ)*ÿ&49ÿ5+4-/)(&4+9ÿG&4Bÿ9-(&'<(-4+ÿ ')51)0,%9ÿ4B-4ÿ'-,ÿ/+ÿ*)0,%ÿ&,ÿ*))%ÿ12)%0'49ÿ90'Bÿ-9ÿ Y+;+4-/(+9ÿ-,%ÿ*20&49ÿM>7Nÿ@ÿK,ÿ;+,+2-(.ÿ-,4&4B2)5/)4&'ÿ%20;9ÿ 2+12+9+,4ÿ-,ÿ-,-(<4&'-((<ÿ'B-((+,;&,;ÿ'(-99ÿ)*ÿ%20;9ÿ/+8ÿ '-09+ÿ2+(-4&Y+(<ÿ(&5&4+%ÿ9420'402-(ÿ&,*)25-4&),ÿ&9ÿ-Y-&(-/(+ÿ *)2ÿ4B+9+ÿ')51)0,%9@ÿo,(&W+ÿ5)94ÿ%20;9.ÿ4B+ÿ-'40-(ÿ+**+'4ÿ )*ÿ-,4&4B2)5/)4&'ÿ%20;9ÿ'-,ÿ)*4+,ÿ/+ÿ2+-%&(<ÿ5+-902+%ÿ 4B2)0;Bÿ-99+995+,4ÿ)*ÿ4B+ÿ12)4B2)5/&,ÿ4&5+ÿ#D[:ÿ)2ÿ4B+ÿ -'4&Y-4+%ÿ1-24&-(ÿ4B2)5/)1(-94&,ÿ4&5+ÿ#-D[[:ÿM>nNÿ.ÿ-,%ÿ 4B+9+ÿ+**+'4ÿ5-2W+29ÿ2+12+9+,4ÿ5)2+ÿ2+(+Y-,4ÿ5+-902+9ÿ)*ÿ 4B+2-1+04&'ÿ2+91),9+ÿ4B-,.ÿ*)2ÿ+3-51(+.ÿ4B+ÿ(+Y+(9ÿ)*ÿ90'Bÿ -ÿ%20;ÿ&,ÿ02&,+ÿ)2ÿ1(-95-@ÿK4ÿG)0(%ÿ4B09ÿ/+ÿ/+,+C'&-(ÿ4)ÿ )/4-&,ÿ5)2+ÿ9420'402-(ÿ&,*)25-4&),ÿ),ÿ4B+9+ÿ')51)0,%9.ÿ

(7)

01ÿ34567ÿ87ÿ941ÿÿ 5 694ÿ5ÿ4694ÿ8545ÿÿÿ ÿ !"ÿ #$%ÿ&'()*+&ÿ,-ÿ(.(+-/0.1ÿ2%31ÿ/4(.2(%2/ÿ$%ÿ*$4&.40(++-ÿ,-ÿ

0.4&%%$1(40.1ÿ&'0/40.1ÿ)&4(,$+$)05/ÿ2(4(/&4/ÿ3/0.1ÿ2(4(ÿ &'4%(540$.ÿ*%$5&23%&/ÿ(.26$%ÿ2(4(ÿ7+4&%0.1ÿ4&58.093&/:ÿ/358ÿ (/ÿ;)(//ÿ2&#&54ÿ7+4&%0.1<ÿ=>?@AÿÿB0.(++-:ÿ48&ÿ/&+&54&2ÿ(.(+-4Cÿ 05(+ÿD$%EF$Dÿ(.2ÿ2(4(ÿ*%$5&//0.1ÿ*0*&+0.&ÿ(+/$ÿ2&4&%)0.&ÿ D8058ÿ2%31/ÿ5(.ÿ,&ÿ02&.407&2AÿG$)&ÿ2%31/ÿ(%&ÿ4$$ÿ/)(++ÿ4$ÿ ,&ÿ5$.72&.4+-ÿ02&.407&2ÿ3/0.1ÿ48&ÿ2&/5%0,&2ÿ)&4(,$+$)05/ÿ D$%EF$D:ÿ/$)&ÿ10H&ÿ%0/&ÿ4$ÿ(.ÿ0./3#750&.4ÿ.3),&%ÿ$#ÿ #%(1)&.4ÿ0$./ÿ#$%ÿ5$.72&.4ÿ02&.4075(40$.:ÿ(.2ÿ$48&%/ÿ)(-ÿ 0.ÿ#(54ÿ,&ÿ*%&/&.4ÿ,34ÿ%&)(0.ÿ3.02&.407&2:ÿ#$%ÿ&'()*+&ÿ 0#ÿ48&ÿ)(//ÿ/*&54%(ÿ$#ÿ(ÿ+$Dÿ(,3.2(.5&ÿ2%31ÿ2$ÿ.$4ÿ )&&4ÿ48&ÿ7+4&%0.1ÿ5%04&%0(ÿ/&4ÿ,-ÿ2(4(ÿ*%$5&//0.1ÿ/$#4D(%&ÿ 4$$+/AÿI8&/&ÿ+0)04(40$./ÿ(%&:ÿ8$D&H&%:ÿ/3,J&54ÿ4$ÿ4&58.$Cÿ +$105(+ÿ2&H&+$*)&.4:ÿ(.2ÿ0)*%$H&2ÿ(.(+-405(+ÿ0./4%3)&.4/ÿ D048:ÿ#$%ÿ&'()*+&:ÿ8018&%ÿ%&/$+H0.1ÿ5(*(,0+040&/:ÿ(22&2ÿ 20)&./0$./ÿ$#ÿ/&*(%(40$.ÿKÿ8LÿMNCOGÿ5$),0.&2ÿD048ÿ0$.ÿ )$,0+04-ÿ/*&54%$)&4%-Pÿ$%ÿ5$)*+&)&.4(%-ÿ#%(1)&.4(40$.ÿ 4&58.093&/ÿKÿ8LÿOGÿD048ÿ580)&%05ÿ#%(1)&.4(40$.ÿ5&++/P:ÿ(%&ÿ &'*&54&2ÿ4$ÿ%&235&ÿ48&ÿ0)*(54ÿ$#ÿ/358ÿ(.(+-405(+ÿ,0(/AÿG358ÿ 2&H&+$*)&.4/ÿD0++ÿ(++$Dÿ#$%ÿ%&2350.1ÿ48&ÿ.3),&%ÿ$#ÿ#(+/&ÿ .&1(40H&/ÿK4-*&ÿQQÿ&%%$%P:ÿD8058ÿ(%&ÿ%&+(40H&+-ÿ8018ÿ0.ÿOGCÿ ,(/&2ÿ)&4(,$+$)05/ÿ3*$.ÿ48&ÿ(**+05(40$.ÿ$#ÿ8018ÿ93(+04-ÿ %&#&%&.5&ÿ/*&54%(ÿ(.2ÿ/4%0.1&.4ÿ02&.4075(40$.ÿ5%04&%0(ÿ4$ÿ )0.0)0R&ÿ#(+/&ÿ20/5$H&%-ÿ%(4&/ÿK4-*&ÿQÿ&%%$%Pÿ=Sÿ:ÿ>T@ÿAÿ

UH&.ÿD048ÿ48&ÿ53%%&.4ÿ/4(%4C$#C(%4:ÿ3%0.&ÿ)&4(,$+$)05/ÿ 2(4(ÿ$##&%ÿ(ÿ8018ÿ02&.4075(40$.ÿ5(*(504-ÿ#$%ÿ/-/4&)05(++-Cÿ (2)0.0/4&%&2ÿ2%31/:ÿ(.2ÿ*%$,(,+-ÿ48&ÿ)$/4ÿ/01.075(.4ÿ0)Cÿ *%$H&)&.4ÿ5(.ÿ,&ÿ(580&H&2ÿ,-ÿ5$)*+&)&.40.1ÿ48&/&ÿ2(4(ÿ D048ÿ*+(/)(ÿ)&4(,$+$)05/ÿ2(4(AÿI8&ÿH(+3&ÿ$#ÿ3/0.1ÿ48&/&ÿ 2(4(ÿ4$ÿ*%$H02&ÿ&H02&.5&ÿ$#ÿ2%31ÿ3/&ÿ0/ÿ(%13(,+-ÿ+0)04&2ÿ #$%ÿ+$5(++-C(2)0.0/4&%&2ÿ2%31/ÿ(.2ÿ2%31/ÿ3/&2ÿ$.ÿ(.ÿ;(/ÿ .&&2&2<ÿ,(/0/:ÿ(+48$318ÿ$3%ÿD$%Eÿ2$&/ÿ/8$Dÿ48(4ÿ/358ÿ 2%31/ÿ)(-ÿ/40++ÿ,&ÿ02&.407&2AÿB$53/0.1ÿ$.ÿ/-/4&)05(++-Cÿ (2)0.0/4&%&2ÿ2%31/ÿ0.4&.2&2ÿ#$%ÿ+$.1C4&%)ÿ3/&ÿ0/ÿ483/ÿ +0E&+-ÿ)$/4ÿ%&+&H(.4:ÿ(+48$318ÿ48&ÿ(22&2ÿH(+3&ÿ$#ÿ%&4%0&HCÿ 0.1ÿ)$+&53+(%ÿ&H02&.5&ÿ$#ÿ2%31ÿ3/&ÿ#%$)ÿ)&4(,$+$)05/ÿ 2(4(ÿ)(-ÿH(%-ÿ,&4D&&.ÿ2%31ÿ5+(//&/ÿ$%ÿ5+0.05(+ÿ/4320&/Aÿ O$%&$H&%:ÿ20/5%&*(.50&/ÿ,&4D&&.ÿ2%31ÿ&.4%0&/ÿ+0/4&2ÿ0.ÿ5+0.Cÿ 05(+ÿ2(4(,(/&/ÿ(.2ÿ2%31/ÿ02&.407&2ÿ,(/&2ÿ$.ÿ)&4(,$+$)05/ÿ 2(4(ÿ)(-ÿ,&ÿ(,/&.4ÿ$%ÿ0./01.075(.4ÿ0.ÿ)(.-ÿ5(/&/:ÿ,34ÿ 5$3+2ÿ*$4&.40(++-ÿ,&ÿ)$%&ÿ*%$.$3.5&2:ÿ(/ÿD&ÿ#$3.2ÿ#$%ÿ 203%&405ÿ2%31/ÿ$#ÿD8058ÿ"ÿD&%&ÿ&'*&54&2ÿKÿ8Lÿ#3%$/&)02&:ÿ !ÿVWÿ8-2%$58+$%$480(R02&:ÿXÿVWÿ0.2(*()02&:ÿ!ÿVPÿ(.2ÿ>!ÿ D&%&ÿ#$3.2ÿKÿ8Lÿ()0+$%02&:ÿ!ÿVWÿ#3%$/&)02&:ÿ!YÿVWÿ8-Cÿ 2%$58+$%$480(R02&:ÿXÿVWÿ0.2(*()02&:ÿ!ÿVPAÿ

B0.(++-:ÿ48&ÿ5$)*+&4&.&//ÿ$#ÿ)&205(40$.ÿ%&5$%2/ÿ#$%ÿ/3,Cÿ J&54/ÿ0.5+32&2ÿ0.ÿ48&ÿ*%&/&.4&2ÿD$%Eÿ)(-ÿ20##&%ÿ#%$)ÿ$48&%ÿ 5+0.05(+ÿ/4320&/AÿI83/ÿD&ÿ2$ÿ.$4ÿ%&5$))&.2ÿ*&%#$%)0.1ÿ )&4(,$+$)05/ÿ(.(+-/&/ÿ/$+&+-ÿ#$%ÿ48&ÿ*3%*$/&ÿ$#ÿH&%0#-0.1ÿ 2%31ÿ0.#$%)(40$.ÿ*%&/&.4ÿ0.ÿ5+0.05(+ÿ2(4(,(/&/:ÿ(+48$318ÿ 3.&'*&54&2ÿ2%31ÿ7.20.1/ÿ(%&ÿ.$4ÿ+0)04&2ÿ4$ÿ$3%ÿ/432-ÿ

=>S@ÿAÿZ.2ÿ0#ÿ2&/0%&2:ÿD&ÿ(5E.$D+&21&ÿ48(4ÿ2&205(4&2ÿ2%31ÿ /5%&&.0.1ÿ)&48$2/ÿD8058ÿ(%&ÿ(H(0+(,+&ÿ0.ÿ)(.-ÿ8$/*04(+/ÿ (.2ÿ5+0.05(+ÿ+(,$%(4$%0&/:ÿ(%&ÿ48&ÿ)&48$2/ÿ$#ÿ58$05&ÿ#$%ÿ 2%31ÿ/5%&&.0.1ÿ*3%*$/&/AÿQ#ÿ$.+-ÿ)&4(,$+$)05/ÿ(.(+-/&/ÿ (%&:ÿ8$D&H&%:ÿ*&%#$%)&2ÿ$.ÿ/()*+&/ÿ#%$)ÿ5+0.05(+ÿ/432Cÿ

0&/:ÿD&ÿ2$ÿ/311&/4ÿ0.4&%%$1(40.1ÿ48&ÿ)&4(,$+$)05/ÿ2(4(ÿ D8058ÿ(%&ÿ,&5$)0.1ÿ0.5%&(/0.1+-ÿ(H(0+(,+&ÿ0.ÿ&*02&)0$+$1Cÿ 05(+ÿ/4320&/ÿ=X:ÿÿ[ÿ:ÿY@ÿ:ÿ4$ÿ%&4%0&H&ÿ)$+&53+(%ÿ&H02&.5&ÿ$#ÿ2%31ÿ 3/&ÿ(.2ÿ*$4&.40(++-ÿ(+/$ÿ4$ÿ4(%1&4ÿ.34%040$.Cÿ(.26$%ÿ+0#&/4-+&Cÿ %&+(4&2ÿ(.(+-4&/:ÿD8058ÿ5$3+2ÿ5$)*+&)&.4ÿ(.2ÿ/4%&.148&.ÿ 2(4(,(/&/ÿ0.ÿ*$*3+(40$.C,(/&2ÿ/4320&/AÿI80/ÿ(**+05(40$.ÿ0/ÿ 5$./0/4&.4ÿD048ÿ4-*05(+ÿ)&4(,$+$)05/ÿ*%(5405&/ÿ%&1(%20.1ÿ *%&C(.(+-405(+ÿ#(54$%/ÿ=X\@ÿ:ÿ(.(+-405(+ÿ/432-ÿ2&/01./ÿ=!X@ÿ:ÿ (.2ÿ2(4(ÿ*%$5&//0.1ÿ*%$5&23%&/ÿ=![:ÿÿX!@ÿ:ÿ(+48$318ÿ04ÿ/8$3+2ÿ ,&ÿ&)*8(/0R&2ÿ48(4ÿ&'$1&.$3/ÿ(.(+-4&/ÿ(%&ÿ$#4&.ÿ$.+-ÿ *%&/&.4ÿ0.ÿ+0)04&2ÿ.3),&%/ÿ$#ÿ/()*+&/:ÿ8&.5&ÿ*$*3+(%ÿ2(4(ÿ %&23540$.ÿ4&58.093&/ÿ+0E&ÿ48&ÿ;T\]ÿ%3+&<ÿ/8$3+2ÿ.$4ÿ,&ÿ(*Cÿ *+0&2ÿ4$ÿ&'4%(54ÿ5$%%&/*$.20.1ÿ0.#$%)(40$.:ÿ(/ÿ20/53//&2ÿ *%&H0$3/+-ÿ=S@ÿAÿ

^_ÿ`abcdefgabÿ

O&4(,$+$)05/ÿ0/ÿ0.5%&(/0.1+-ÿ(**+0&2ÿ4$ÿ*$*3+(40$.Cÿ ,(/&2ÿ(.2ÿ&*02&)0$+$105(+ÿ/4320&/ÿD048ÿ48&ÿ(0)ÿ$#ÿ&+3Cÿ 502(40.1ÿ20/&(/&ÿ)&58(.0/)/ÿ(.2ÿ20/5$H&%0.1ÿ20(1.$/405ÿ $%ÿ*%$1.$/405ÿ,0$)(%E&%/ÿ=Xÿ:[ÿÿ:ÿY@ÿAÿN$%%&/*$.20.1ÿ(.(+-4Cÿ 05(+ÿD$%EF$D/ÿ-0&+2ÿ5$)*%&8&./0H&ÿ0.#$%)(40$.ÿ$.ÿ.3Cÿ )&%$3/ÿ&.2$1&.$3/ÿ)&4(,$+04&/ÿD80+&ÿ2(4(ÿ#$%ÿ&'$1&.$3/:ÿ +$DC)$+&53+(%CD&0184ÿ5$)*$3.2/ÿ/358ÿ(/ÿ2%31/ÿ(%&ÿ$#4&.ÿ 5$C(5930%&2ÿD0480.ÿ48&ÿ/()&ÿ(.(+-/&/AÿO&4(,$+$)05/ÿ2(4(ÿ 5(.ÿ48&%&,-ÿ,&ÿ3/&#3+ÿ4$ÿH&%0#-ÿ(.2ÿ/4%&.148&.ÿ48&ÿK/&+#Cÿ %&*$%4&2Pÿ0.#$%)(40$.ÿ$.ÿ2%31ÿ3/&ÿ*%&/&.4ÿ0.ÿ&*02&)0$Cÿ +$105(+ÿ2(4(,(/&/:ÿ(/ÿ/8$D.ÿ0.ÿ48&ÿ*%&/&.4&2ÿD$%EAÿI80/ÿ D$%Eÿ(+/$ÿ0.205(4&2ÿ48(4ÿ(ÿ5$./02&%(,+-ÿ8018ÿ02&.4075(40$.ÿ 5(*(504-ÿ#$%ÿ/-/4&)05(++-C(2)0.0/4&%&2ÿ2%31/ÿ5$3+2ÿ,&ÿ%&Cÿ (+0/&2ÿ,-ÿ0.4&%%$1(40.1ÿ3%0.&ÿ)&4(,$+$)05/ÿ2(4(:ÿ(.2ÿ(.ÿ &H&.ÿ8018&%ÿ02&.4075(40$.ÿ5(*(504-ÿ0/ÿ&'*&54&2ÿD8&.ÿ5$)Cÿ *+&)&.40.1ÿ48&/&ÿ2(4(ÿD048ÿ*+(/)(ÿ)&4(,$+$)05/ÿ2(4(AÿB0Cÿ .(++-:ÿ(+48$318ÿ48&ÿ5$.5&*4ÿ$#ÿ*%$H020.1ÿ)$+&53+(%ÿ&H0Cÿ 2&.5&ÿ#$%ÿ2%31ÿ3/&ÿ)(-ÿ,&ÿ+0)04&2ÿ#$%ÿ+$5(++-C(2)0.0/4&%&2ÿ K(.2ÿ+$5(++-C(540H&Pÿ2%31/ÿ(.2ÿ2%31/ÿ3/&2ÿ$.ÿ(.ÿ;(/ÿ.&&2&2<ÿ ,(/0/:ÿ)$+&53+(%ÿ&H02&.5&ÿ5(.ÿ,&ÿ$,4(0.&2ÿ#$%ÿ)(.-ÿ2%31/ÿ 48(4ÿ(%&ÿ#%&93&.4+-ÿ/4320&2ÿ0.ÿ*$*3+(40$.C,(/&2ÿ/4320&/ÿ 48%$318ÿ/&+#C%&*$%4&2ÿ2(4(ÿD8058ÿ)(-ÿ,&ÿ/3,J&54ÿ4$ÿ5$.Cÿ /02&%(,+&ÿ,0(/Aÿ

heiidjkjblmnoÿkmljngmdfÿ

G3**+&)&.4(%-ÿ)(4&%0(+ÿ(//$50(4&2ÿD048ÿ480/ÿ(%405+&ÿ5(.ÿ ,&ÿ#$3.2:ÿ0.ÿ48&ÿ$.+0.&ÿH&%/0$.:ÿ(4ÿ2$0pÿ!\A!\!Y6JAJ5+0.&*0Aÿ

>\>!A\>A\\TÿAÿ

`qjrgsÿmeltanftgiÿcablnguelgabÿflmljkjblÿ

vnmbwÿxdablyÿN$.5&*43(+0R(40$.:ÿO&48$2$+$1-:ÿB$%)(+ÿ (.(+-/0/:ÿQ.H&/401(40$.:ÿz%040.1ÿCÿ$%010.(+ÿ2%(#4:ÿz%040.1ÿ Cÿ%&H0&Dÿ{ÿ&2040.1:ÿ|0/3(+0R(40$.:ÿB3.20.1ÿ(5930/040$.Aÿ }mmbÿxnjkjnyÿ~(4(ÿ53%(40$.:ÿz%040.1ÿCÿ%&H0&Dÿ{ÿ&204Cÿ 0.1Aÿblabgaÿ€_ÿakjfÿ‚jlayÿ~(4(ÿ53%(40$.:ÿz%040.1ÿCÿ %&H0&Dÿ{ÿ&2040.1Aÿhljƒmbÿ„_ÿ…jn†jnyÿ~(4(ÿ53%(40$.:ÿz%04Cÿ 0.1ÿCÿ%&H0&Dÿ{ÿ&2040.1Aÿ}mmbÿ‡_ÿsaeˆyÿO&48$2$+$1-:ÿ

(8)

01ÿ 34ÿ56789ÿ9ÿ 64ÿ ÿ 78 6ÿ7ÿ68 6ÿ767ÿÿ ÿ!"ÿ #$%&%'(ÿ)ÿ$*+%*,ÿ-ÿ*.%&%'(/ÿ01234ÿ5637ÿ8*&9:.:;)ÿ

:(<=ÿ#$%&%'(ÿ)ÿ$*+%*,ÿ-ÿ*.%&%'(/ÿ>4?ÿ@4??1A7ÿ8*&9:.)ÿ :;:(<=ÿB:$CD;ÿD'D;<E%E=ÿ#$%&%'(ÿ)ÿ$*+%*,ÿ-ÿ*.%&%'(/ÿ FG1HI6?ÿJKLKÿ@6331A7ÿM:'N*O&PD;%QD&%:'=ÿ8*&9:.:;:(<=ÿ R*E:P$N*E=ÿ#$%&%'(ÿ)ÿ$*+%*,ÿ-ÿ*.%&%'(=ÿSPO*$+%E%:'=ÿBP'.)ÿ %'(ÿDNTP%E%&%:'/ÿUVA6AWÿ54HXY6AG?1A7ÿM:'N*O&PD;%QD&%:'=ÿ 8*&9:.:;:(<=ÿR*E:P$N*E=ÿ#$%&%'(ÿ)ÿ$*+%*,ÿ-ÿ*.%&%'(=ÿSP)ÿ O*$+%E%:'=ÿBP'.%'(ÿDNTP%E%&%:'/ÿ

>1X1A1?Z1[ÿ

\0]ÿ#%;;%DCEÿRÿ=ÿ#$%(9&ÿ^ÿ/ÿ_O%.*C%:;:(%ND;ÿ%EEP*Eÿ%'ÿ9*D;&9ÿ'**.EÿDE)ÿ

E*EEC*'&/ÿ`8^ÿ0aabcd01e0dfagbhÿ/ÿ

\h]ÿi*D$N*ÿjÿ/ÿk$D.%&%:'D;ÿ*O%.*C%:;:(<=ÿC:.*$'ÿ*O%.*C%:;:(<=ÿD'.ÿOPl)ÿ

;%Nÿ9*D;&9/ÿmCÿ^ÿiPl;%Nÿn*D;&9ÿ0aa1cb1e1fbgbdÿ/ÿ

\d]ÿM:P(9;%'ÿSS/ÿÿk:,D$.ÿDÿ$:D.ÿCDOÿo:$ÿ(;:lD;ÿ):C%NEeÿDÿO$%C*$ÿ:'ÿ

):C%Nÿ&*N9':;:(%*E/ÿmCÿ^ÿ_O%.*C%:;ÿhp0qc0bpe00bbgarÿ/ÿ

\q]ÿ_+*$E:'ÿk8ÿ=ÿ8D$E%&ÿM^ÿ/ÿs'&*($D&%'(ÿ)tC%NEÿmOO$:DN9*Eÿ%'&:ÿnPCD'ÿ

i:OP;D&%:')`DE*.ÿS&P.%*Eÿ:oÿi$*'D&D;ÿD'.ÿ_D$;<)u%o*ÿ_vO:EP$*E/ÿMP$$ÿ

_'+%$:'ÿn*D;&9ÿR*Oÿhp0bcredhbgdfÿ/ÿ

\r]ÿm&w%'ÿm^ÿ=ÿx:$*;<ÿkÿ=ÿM;*C*EÿSmÿ=ÿyD&*Eÿkÿ=ÿ_.,D$.E:'ÿMÿ=ÿ`$D(*ÿSÿ=ÿ

*&ÿD;/ÿ8*&9:.Eÿ:oÿ8*DEP$*C*'&ÿ%'ÿ*O%.*C%:;:(<eÿE*.*'&D$<ÿ`*)ÿ

9D+%:P$/ÿs'&ÿ^ÿ_O%.*C%:;ÿhp0hcq0e0q1pgf0ÿ/ÿ

\1]ÿz*9(9D'ÿmÿ/ÿ8DEEÿEO*N&$:C*&$<ÿ%'ÿ*O%.*C%:;:(%ND;ÿE&P.%*Eeÿ#9D&ÿD$*ÿ

&9*ÿw*<ÿN:'E%.*$D&%:'E{ÿ_P$ÿ^ÿ_O%.*C%:;ÿhp01cd0ef0rg01ÿ/ÿ

\f]ÿRD&&$D<ÿj^#ÿ=ÿz*Q%*;ÿjMÿ=ÿ#D;;DN9ÿ^zÿ=ÿ|9D'ÿSmÿ=ÿ}DE%;%:Pÿ}ÿ=ÿs:D''%)ÿ

.%Eÿ^imÿ=ÿ*&ÿD;/ÿ`*<:'.ÿ(*':C%NEeÿP'.*$E&D'.%'(ÿ*vO:E:&<O*Eÿ&9$:P(9ÿ

C*&Dl:;:C%NE/ÿnPCÿx*':C%NEÿhp0bc0heqÿ/ÿ

\b]ÿ#%E9D$&ÿzS/ÿÿ_C*$(%'(ÿDOO;%ND&%:'Eÿ:oÿC*&Dl:;:C%NEÿ%'ÿ.$P(ÿ.%EN:+)ÿ

*$<ÿD'.ÿO$*N%E%:'ÿC*.%N%'*/ÿjD&ÿR*+ÿz$P(ÿz%EN:+ÿhp01c0reqfdgbqÿ/ÿ

\a]ÿ|;:'&ÿBÿ=ÿ^D9'ÿSÿ=ÿx$%+*&ÿMÿ=ÿ|:'%(ÿSÿ=ÿ`:''*$ÿR=ÿÿn:Oo(D$&'*$ÿxÿ/ÿ

S#mknÿ.D&Dÿ%'.*O*'.*'&ÿDNTP%E%&%:'ÿCDEEÿEO*N&$:C*&$<ÿo:$ÿEN$**')ÿ

%'(ÿ:oÿv*':l%:&%NEÿ%'ÿl%:;:(%ND;ÿ~P%.EeÿtOO:$&P'%&%*EÿD'.ÿN9D;;*'(*Eÿ

o:$ÿ.D&DÿO$:N*EE%'(/ÿkD;D'&Dÿhphpch00e0hpfqfÿ/ÿ

\0p]ÿi$%'N*ÿSm=ÿÿm.DC:ÿ|`ÿ=ÿnDC*;ÿ8_ÿ=ÿnD$.&ÿ^ÿ=ÿM:'':$ÿx:$l*$ÿSÿ=ÿ

k$*Cl;D<ÿ8ÿ/ÿmÿN:COD$%E:'ÿ:oÿ.%$*N&ÿ+*$EPEÿE*;o)$*O:$&ÿC*DEP$*Eÿ

o:$ÿDEE*EE%'(ÿO9<E%ND;ÿDN&%+%&<ÿ%'ÿD.P;&EeÿDÿE<E&*CD&%Nÿ$*+%*,/ÿs'&ÿ^ÿ

`*9D+ÿjP&$ÿi9<EÿmN&ÿhppbcrer1ÿ/ÿ

\00]ÿm;&CD%*$ÿ_=ÿÿ|DE&*'CP;;*$ÿxÿ=ÿR:C%EN9)8D$(;ÿ#ÿ=ÿk9:$D'.ÿ`ÿ=ÿ#*%')ÿ

l*$(*$ÿ|8ÿ=ÿs;;%(ÿkÿ=ÿ*&ÿD;/ÿP*E&%:''D%$*)lDE*.ÿE*;o)$*O:$&*.ÿ'P&$%&%:'ÿ

9Dl%&EÿDEE:N%D&*ÿ,%&9ÿE*$PCÿC*&Dl:;%ECÿDEÿ$*+*D;*.ÿl<ÿTPD'&%&D&%+*ÿ

&D$(*&*.ÿC*&Dl:;:C%NE/ÿ_P$ÿ^ÿ_O%.*C%:;ÿhp00ch1e0qrgr1ÿ/ÿ

\0h]ÿ+D'ÿ.*'ÿ`*$(ÿ_ÿ=ÿiDEN9ÿmÿ=ÿ#*E&*'.:$Oÿ#nÿ=ÿjD+%Eÿxÿ=ÿ`$%'wÿ_^ÿ=ÿ

xD'EÿRtÿ=ÿ*&ÿD;/ÿ€$%'D$<ÿEP;oP$ÿC*&Dl:;%&*EÿDEE:N%D&*ÿ,%&9ÿDÿoD+:$Dl;*ÿ

ND$.%:+DENP;D$ÿ$%EwÿO$:;*ÿD'.ÿEP$+%+D;ÿl*'*&ÿ%'ÿ$*'D;ÿ&$D'EO;D'&ÿ

$*N%O%*'&E/ÿ^ÿmCÿS:Nÿj*O9$:;ÿhp0qchre0dpdg0hÿ/ÿ

\0d]ÿ`$:D.9P$E&ÿzÿ=ÿx::.DN$*ÿRÿ=ÿR*%'w*ÿSjÿ=ÿ|P;%(:,Ew%ÿ^ÿ=ÿ#%;E:'ÿszÿ=ÿ

u*,%Eÿ8Rÿ=ÿ*&ÿD;/ÿxP%.*;%'*EÿD'.ÿN:'E%.*$D&%:'Eÿo:$ÿ&9*ÿPE*ÿ:oÿE<E&*Cÿ

EP%&Dl%;%&<ÿD'.ÿTPD;%&<ÿN:'&$:;ÿEDCO;*Eÿ%'ÿCDEEÿEO*N&$:C*&$<ÿDEED<Eÿ

DOO;%*.ÿ%'ÿP'&D$(*&*.ÿN;%'%ND;ÿC*&Dl:;:C%NÿE&P.%*E/ÿ8*&Dl:;:C%NEÿ

hp0bc0qefhÿ/ÿ

\0q]ÿSPC'*$ÿu#ÿ=ÿmCl*$(ÿmÿ=ÿ`D$$*&&ÿzÿ=ÿ`*D;*ÿ8nÿ=ÿ`*(*$ÿRÿ=ÿzD<w%'ÿMmÿ=ÿ

*&ÿD;/ÿi$:O:E*.ÿC%'%CPCÿ$*O:$&%'(ÿE&D'.D$.Eÿo:$ÿN9*C%ND;ÿD'D;<E%Eÿ

M9*C%ND;ÿm'D;<E%Eÿ#:$w%'(ÿx$:POÿ‚Mm#xƒÿ8*&Dl:;:C%NEÿS&D')ÿ

.D$.Eÿs'%&%D&%+*ÿ‚8Ssƒ/ÿ8*&Dl:;:C%NE/ÿhppfcdeh00gh0ÿ/ÿ

\0r]ÿkEP(D,Dÿnÿ=ÿMD„wDÿkÿ=ÿ|%'.ÿkÿ=ÿ8Dÿyÿ=ÿn%((%'Eÿ`ÿ=ÿsw*.Dÿ|ÿ=ÿ*&ÿD;/ÿ8Sg zsmueÿ.D&D)%'.*O*'.*'&ÿ8S…8Sÿ.*N:'+:;P&%:'ÿo:$ÿN:CO$*9*'E%+*ÿ

C*&Dl:;:C*ÿD'D;<E%E/ÿjD&ÿ8*&9:.Eÿhp0rc0herhdg1ÿ/ÿ

\01]ÿSN9DN9&*$ÿ8ÿ/ÿM9*C%ND;=ÿO9D$CDN:w%'*&%NÿD'.ÿO9D$CDN:.<'DC%Nÿ

O$:O*$&%*Eÿ:oÿE&D&%'EeÿD'ÿPO.D&*/ÿBP'.DCÿM;%'ÿi9D$CDN:;ÿ

hpprc0ae00fghrÿ/ÿ

\0f]ÿiD$wÿSÿ=ÿn<P'ÿy^ÿ=ÿ|%CÿyRÿ=ÿu**ÿ^nÿ=ÿR<PÿSÿ=ÿ|%Cÿ^8ÿ=ÿ*&ÿD;/ÿ_o)ÿ

o*N&Eÿ:oÿMyihM0aÿx*'*&%Nÿi:;<C:$O9%ECEÿ:'ÿi|…izÿR*EO:'E*Eÿ

:oÿtC*O$DQ:;*ÿ%'ÿ|:$*D'ÿn*D;&9<ÿ}:;P'&**$E/ÿ^ÿ|:$*D'ÿ8*.ÿSN%ÿ

hp0fcdhefhagd1ÿ/ÿ

\0b]ÿjDwD%ÿnÿ=ÿS9%CDCP$Dÿyÿ=ÿ|D'DQD,Dÿkÿ=ÿyDEP.DÿSÿ=ÿ|D<D':ÿ8ÿ/ÿz*)ÿ

&*$C%'D&%:'ÿ:oÿDÿ'*,ÿnÿ†ÿ‡|†ÿÿmkiDE*ÿ%'9%l%&:$ÿ‚_db0pƒÿD'.ÿ%&Eÿ

o:P$ÿC*&Dl:;%&*Eÿ%'ÿ9PCD'ÿO;DECDÿl<ÿ9%(9)O*$o:$CD'N*ÿ;%TP%.ÿN9$:)ÿ

CD&:($DO9</ÿ^:P$'D;ÿ:oÿM9$:CD&:($DO9<ÿ`eÿ`%:C*.%ND;ÿSN%*'N*EÿD'.ÿ

mOO;%ND&%:'Eÿ0aaqc11peh00ghpÿ/ÿ

\0a]ÿR*',%Nwÿmxÿ=ÿR:l*$&E:'ÿzRÿ=ÿ8DNw;%'ÿ`ÿ=ÿM9D;;*':$ÿ}=ÿÿ#D;;*$ÿzxÿ=ÿ

x*:$(*ÿMBÿ/ÿk9*ÿO9D$CDN:w%'*&%NEÿ:oÿ:$D;ÿ'%o*.%O%'*gDÿO:OP;D&%:'ÿ

E&P.</ÿ`$ÿ^ÿM;%'ÿi9D$CDN:;ÿ0abbchrefp0gbÿ/ÿ

\hp]ÿM:;PNN%ÿiÿ=ÿyP*ÿMSÿ=ÿzPN9D$C*ÿ8ÿ=ÿ`*'+*'(DÿSÿ/ÿmÿR*+%*,ÿ:oÿ&9*ÿ

i9D$CDN:w%'*&%NEÿ:oÿu*+:&9<$:v%'*ÿo:$ÿ&9*ÿk$*D&C*'&ÿ:oÿn<O:&9<)ÿ

$:%.%EC/ÿ_P$ÿ_'.:N$%':;ÿhp0dcaeqpgfÿ/ÿ

\h0]ÿuDO:$&*ÿ^Rÿ=ÿslD'*Qÿuÿ=ÿ}%.D;ÿˆ=ÿÿ}*'.$*;;ÿuÿ=ÿu*:'*ÿRÿ/ÿ€OO*$ÿ(DE&$:%')ÿ

&*E&%'D;ÿl;**.%'(ÿDEE:N%D&*.ÿ,%&9ÿ&9*ÿPE*ÿ:oÿjSmszEeÿ'*,*$ÿ+*$EPEÿ

:;.*$ÿD(*'&E/ÿz$P(ÿSDoÿhppqchfeq00ghpÿ/ÿ

\hh]ÿS*.%TÿRÿ=ÿ+D'ÿ.*$ÿSN9D'Eÿ^ÿ=ÿz:&%'(Dÿmÿ=ÿm;%'(9ÿRmÿ=ÿ#%;oo*$&ÿ`ÿ=ÿ

`:Eÿ^nÿ=ÿ*&ÿD;/ÿM:'N:$.D'N*ÿDEE*EEC*'&ÿ:oÿE*;o)$*O:$&*.ÿC*.%ND&%:'ÿ

PE*ÿ%'ÿ&9*ÿj*&9*$;D'.Eÿ&9$**)(*'*$D&%:'ÿu%o*;%'*EÿM:9:$&ÿE&P.<ÿ,%&9ÿ

&9*ÿO9D$CDN<ÿ.D&DlDE*ÿ%Dz`/';eÿk9*ÿi9D$Cu%'*Eÿ%'%&%D&%+*/ÿM;%'ÿ_O%)ÿ

.*C%:;ÿhp0bc0peab0gaÿ/ÿ

\hd]ÿ8D&9*,Eÿj8ÿ/ÿi$:9%l%&*.ÿM:'&DC%'D'&Eÿ%'ÿz%*&D$<ÿSPOO;*C*'&E/ÿ

SO:$&Eÿn*D;&9ÿhp0bc0pe0agdpÿ/ÿ

\hq]ÿk:P,ÿz^ÿ/ÿM;%'%ND;ÿ%CO;%ND&%:'Eÿ:oÿ(*'*&%NÿO:;<C:$O9%ECEÿD'.ÿ.$P(ÿ

%'&*$DN&%:'EÿC*.%D&*.ÿl<ÿM<&:N9$:C*ÿi)qrpÿ*'Q<C*E/ÿz$P(ÿ8*&Dl:;ÿ

z$P(ÿs'&*$DN&ÿ0aafc0qerrgbhÿ/ÿ

\hr]ÿnD$*ÿuxÿ=ÿ#::.E%.*ÿ^}ÿ=ÿy:P'(ÿsS/ÿÿz%*&D$<ÿED;%N<;D&*E/ÿ^ÿM;%'ÿiD&9:;ÿ

hppdcr1e1qagrpÿ/ÿ

\h1]ÿBD+D;:$:ÿ_^ÿ=ÿu%OO%ÿxÿ=ÿ|:P&&Eÿ^ÿ/ÿuDl:$D&:$<ÿ&*E&%'(ÿ:oÿD'&%N:D(P;D'&Eeÿ

&9*ÿO$*E*'&ÿD'.ÿ&9*ÿoP&P$*/ÿiD&9:;:(<ÿhp00cqde1bhgahÿ/ÿ

\hf]ÿ‰9D'(ÿnÿ=ÿ‰9D'(ÿzÿ=ÿRD<ÿ|ÿ=ÿ‰9Pÿ8ÿ/ÿ8DEEÿ.*o*N&ÿ;&*$ÿ&*N9'%TP*ÿD'.ÿ

%&EÿDOO;%ND&%:'Eÿ&:ÿ.$P(ÿC*&Dl:;%&*ÿ%.*'&%ND&%:'ÿl<ÿ9%(9)$*E:;P&%:'ÿ

CDEEÿEO*N&$:C*&$</ÿ^ÿ8DEEÿSO*N&$:Cÿhppacqqeaaag0p01ÿ/ÿ

\hb]ÿSN9*Pl*$&ÿ|ÿ=ÿnPoEw<ÿBÿ=ÿi*&$DEÿz=ÿÿ#D'(ÿ8ÿ=ÿj:&9%DEÿuBÿ=ÿzP9$w:Oÿ|ÿ=ÿ

*&ÿD;/ÿS%('%ND'N*ÿ*E&%CD&%:'ÿo:$ÿ;D$(*ÿEND;*ÿC*&Dl:;:C%NEÿD'':&D)ÿ

&%:'Eÿl<ÿEO*N&$D;ÿCD&N9%'(/ÿjD&ÿM:CCP'ÿhp0fcbe0qaqÿ/ÿ

\ha]ÿ+D'ÿk%;l:$(9).*ÿ^:'(ÿm^ÿ=ÿ#%*$EPC)tEE*;&:'ÿ^Mÿ=ÿk:P,ÿz^ÿ=ÿSN9%O)ÿ

O*$PEÿ8Rÿ/ÿi$*E*'N*ÿ:oÿC*.%ND&%:'ÿ&Dw*'ÿl<ÿl;::.ÿ.:':$Eÿ%'ÿO;DECDÿ

o:$ÿ&$D'EoPE%:'/ÿ}:vÿSD'(ÿhp0rc0pbedhdgfÿ/ÿ

\dp]ÿ`%ÿnÿ=ÿxP:ÿ‰ÿ=ÿ^%Dÿˆÿ=ÿu%Pÿnÿ=ÿ8Dÿuÿ=ÿˆP*ÿuÿ/ÿk9*ÿw*<ÿO:%'&Eÿ%'ÿ&9*ÿO$*g

D'D;<&%ND;ÿO$:N*.P$*Eÿ:oÿl;::.ÿD'.ÿP$%'*ÿEDCO;*Eÿ%'ÿC*&Dl:;:C%NEÿ

E&P.%*E/ÿ8*&Dl:;:C%NEÿhphpc01e1bÿ/ÿ

\d0]ÿu%ÿ‰ÿ=ÿuPÿyÿ=ÿxP:ÿyÿ=ÿMD:ÿnÿ=ÿ#D'(ÿÿ=ÿS9P%ÿ#ÿ/ÿM:CO$*9*'E%+*ÿ

*+D;PD&%:'ÿ:oÿP'&D$(*&*.ÿC*&Dl:;:C%NEÿ.D&DÿO$:N*EE%'(ÿE:o&,D$*ÿ%'ÿ

o*D&P$*ÿ.*&*N&%:'=ÿTPD'&%ND&%:'ÿD'.ÿ.%EN$%C%'D&%'(ÿCD$w*$ÿE*;*N&%:'/ÿ

Referenties

GERELATEERDE DOCUMENTEN

The world’s first stock exchange: how the Amsterdam market for Dutch East India Company shares became a modern securities market, 1602-1700..

It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly

As he puts it: ‘The Kantian idea of moral autonomy does not primarily enlighten us about how we should actually structure our life and actions, but about the

Stabilisation and precision pointing quadrupole magnets in the Compact Linear Collider (CLIC)..

Duration of antibiotic treatment and symptom recovery in community-acquired pneumonia.. El

The spectrum includes both photospheric absorption lines and emission features (H and Ca ii triplet emission lines, 1st and 2nd overtone CO bandhead emission), as well as an

Nadat hij dit voorbeeld behandeld had, wierp Fourier de vraag op of men ook een willekeurige periodieke functie f (t) – stel voor de eenvoud maar weer dat de periode van die functie

Mijn dank gaat in eerste instantie uit naar alle studenten theaterweten- schap van de Universiteit van Amsterdam die in de loop van vier jaar door hun deelname aan het onderwijs