University of Groningen
Stapled peptides inhibitors Ali, Amina
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Ali, A. (2019). Stapled peptides inhibitors: A new window for target drug discovery. University of Groningen.
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Propositions
Belonging to the thesis
Stapled Peptides Inhibitors: A new Window
For Target Drug Discovery
By
Amina M. Ali
1. Stapled peptides define a novel therapeutic modality & show an ability to inhibit intracellular PPIs that intractable with traditional small-molecule or protein-based therapeutics.{This thesis} 2. Stapled peptides fill the gap between small-molecules and biologics, opening an expansive
range of new therapeutic targets that were previously considered “undruggable”. {This thesis} 3. The large, shallow PPI interfaces were challenging to target, until the structural, screening,
synthetic chemistry and computational approaches have been evolved. {My view}
4. Our novel high-resolution structures will open ongoing endeavor to discover new p53-MDM2 PPI inhibitors to overcome the poor clinical and pharmacokinetic properties of the current once in clinical trials. {My view}
5. Great achievement always requires great sacrifices. {Robin Sharma} 6. It is always seems impossible until it’s done. {Nelson Mandela}
7. The greatest pleasure in life is doing what others say you cannot do. {Walter Bagehot}
8. Dream is not the thing you see in sleep,, but is that thing that doesn’t let you sleep. {A. P. J.
Abdul Kalam}
9. Mindset is what separates the best from the rest. {John Assaraf}
10. If you are always trying to be normal,, you will never know how amazing you can be. {Maya
