University of Groningen
Development of novel anticancer agents for protein targets
Estrada Ortiz, Natalia
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2017
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Estrada Ortiz, N. (2017). Development of novel anticancer agents for protein targets. University of
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PPENDIX
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CKNOWLEDGEMENTS
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CKNOWLEDGEMENTS
Finally, after 4 years and a lot of interesting projects, I would like to write a few words in order to express my gratitude to those that helped me reach to this point.
Starting first by thanking the Administrative Department of Science, Technology and Innovation from the Colombian Government (Colciencias) for funding this PhD project.
At the beginning of my PhD, I started working at the Drug Design group, where I had the opportunity to learn about medicinal chemistry. I would like to thank Alex for taking me into his group and give me the chance to work on something completely new for me: organic and medicinal chemistry. Additionally, I want to thank you for the fun cooking afternoons and your world’s famous lasagne. In parallel to my work in the chemistry lab, I started working at the Pharmacokinetics, Toxicology and Targeting group under the supervision of Angela Casini and Geny Groothuis as part of my PhD project. First, I would like to thank Angela, you were my daily supervisor for little bit more than 2 years, you are a very bright scientist, energetic, funny and with great ideas. Thank you very much for all your guidance and help during these 4 years, also I want to thank you for arranging dinners and gatherings with the other members of the group, it was always fun discussing about different topics besides work. I wish you great success in your growing career!
Dear Geny, at the beginning of my PhD you were not directly involved in my projects, but during the last two years we had very fruitful discussions and I got the opportunity to get to know you as a scientist and as a person. You always have great ideas and were available for questions, discussions and even paper work. I really appreciate your help, especially during the last months of my PhD! I would like to thank the members of the assessment committee: Prof. Frank Dekker, Prof. Peter Olinga and Prof. Ronald Pieters for taking their time to evaluate my thesis.
During these 4 years as a PhD student, I had an extra supervisor at the Drug Design group Dinos whom I consider a great friend and scientist (by the way also my paranymph). Thanks for all the training in the lab, the discussions (not just scientific) and all the fun during these years. I wish you all the best and I hope we can keep in touch, we have to arrange your trip to Colombia!
I will like to thank all the staff from both research groups, for the nice atmosphere and help in the labs. I want to thank specially to our lab technicians for all the help, training and support. Andre, you were always available to answer my questions (or complains about the mess in the lab), it was fun sharing the office with you, Edwin and Robin, I wish you all the best and success. Marina and Marjolijn, I’m grateful for all your help and training with the PCTS. Eduard and Catharina, thanks for all your help at the cell culture lab, you were always available to solve my doubts about reagents and protocols (and scanning a few sections). Jan Visser, thanks for the technical support, the lab tour and your dedication to keep the labs in order. Gillian, I will miss you a lot, besides being a great secretary, you are an amazing person, always happy and willing to make fun of everyone!
Additionally, I would like to extent my acknowledgements to Prof. Klaas Poelstra, Prof. Barbro Melgert, Dr. Anna Salvaty, Dr. Leonie Beljaars, Dr Sylvia Notenboom, Dr Matthew Grooves and Dr. Inge de Graaf, thank you all for the productive discussions during the group meetings, I wish you great success with your groups and students. Inge, I want to thank you for your help and guidance during the last part of my PhD, I wish you all the best!
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I would like to thank all my colleagues from both groups for the great time, a few special acknowledgments to Daphne, Roberta and Laura, it was great sharing the office with you during the last months of my PhD, you are really sweet girls, I wish you great success with your PhDs and future life. Viktoriia, my paranymph (I hope you don’t miss the opportunity to see the northern lights because of me), I want to thank you for your help with new experiments and the nice discussions, you are a remarkable woman and I know that you will achieve great things in the future. Andreia and Sarah: my “little” sisters, it was a great experience working together, and having fun in and outside of the lab. Sarah, I wish you the best of luck finishing your thesis and your future defense and Andreia, I wish you great success in your career. I would also like to thank my students Federica, Marina and Elena, it was a great experience working with you and developing our projects, good luck for all your future efforts.
I would like to thank my friends Nick, Georgia, Sergio and Juliana for their support and funny times, it was very helpful to relax after stressful days of work!!
And of course, Tryf! Thanks a lot for being there in the happy and stressful times, you were a great support and partner in a personal level but also at work. I admire your patience and your disposition to help everyone, I’m sure that you will be truly successful!
Por último quiero agradecer a mi familia, con su apoyo este proceso fue un poco más fácil. Mis padres y hermano siempre atentos y presentes desde la distancia durante estos 4 años. Mi sobrina Luna que me sacó más de una sonrisa en los momentos más difíciles. Erika, gracias por ser mi “guía de fe” y siempre estar disponible para mí. Muchísimas gracias a mi familia Colombo-Holandesa por apoyarme, ayudarme y acompañarme durante este tiempo. Quiero extender mis agradecimientos a mis amigos de Colombia que a pesar de la distancia siguen presentes: Lina, Andrea, David Ahmedt, Vero y Jhon Fernando.
Natalia 11/09/2017
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ABOUT
THE
AUTHOR
Natalia was born on the 17th of August 1985 in Medellín, Colombia. In 2009, she graduated as a
Biological Engineer from the National University from Colombia, where she continued with her Master studies in Biotechnology. Her master research was focused on the evaluation and screening of natural products obtained from plants and marine sponges with anticancer properties, her Bachelor and master’s theses were carried out under the supervision of Prof. J. B. López Ortiz and Prof. M. E. Márquez Fernández. In 2013, she obtained a scholarship from the Administrative Department of Science, Technology and Innovation form the Colombian Government (Colciencias) which allowed her to move to Groningen to start her PhD studies at the University of Groningen under the supervision of Prof. A. S. S Domling, Prof. G. M. M. Groothuis and Prof. A. Casini in the groups of Drug Design and Pharmacokinetics, Toxicology and Targeting at the Groningen Research Institute for Pharmacy. Her research focused on the design, screening and toxicity studies of organic and metallorganic compounds as anticancer agents. Currently she is a research associate at Vedas Research and Innovation, a Colombian nonprofit organization focused on applied and basic research, formed by several Colombian researchers from diverse areas of knowledge to create a network to exchange knowledge, ideas and collaboration between the Colombian diaspora and international young researchers.
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WARDS2013: Beca Colciencias Doctorado en el exterior (Colciencias’ Scholarship for PhD abroad)
2010: Jovenes investigadores e innovadores (Young Researchers and Innovators), Research grant. Colciencias.
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IST OF PUBLICATIONS:- Estrada-Ortiz, N.;* Neochoritis, C. G.;* Twarda-Clapa, A.; Musielak, B.; Holak, T. A.; Dömling, A. Artificial Macrocycles as Potent P53-MDM2 Inhibitors. ACS Med. Chem. Lett. 2017. doi: 10.1021/acsmedchemlett.7b00219.
- Estrada-Ortiz, N.; Guarra, F.; de Graaf, I. A. M.; Marchetti, L.; de Jager, M. H.; Groothuis, G. M. M.; Gabbiani, C.; Casini, A. Anticancer Gold N-Heterocyclic Carbene Complexes: A Comparative in Vitro and Ex Vivo Study. ChemMedChem 2017, 12 (17), 1429–1435.
- Jürgens, S., Scalcon, V., Estrada-Ortiz, N., Folda, A., Tonolo, F., Jandl, C., Browne, D.L., Rigobello, M.P., Kühn, F.E., Casini, A., 2017. Exploring the C^N^C theme: Synthesis and biological properties of tridentate cyclometalated gold(III) complexes. Bioorg. Med. Chem. doi:10.1016/j.bmc.2017.08.001. - Estrada-Ortiz, N.; Lopez Gonzales, E.; de Graaf, I. A. M.; Post, E.; Groothuis, G. M. M.; Casini, A. Gold (I) Complexes with Lansoprazole-Type Ligands: Ex Vivo Toxicological Evaluation. (Manuscript in preparation).
- Estrada-Ortiz, N.;* Spreckelmeyer, S.;* Prins, G.; Van der Zee, M.; Post, E.; de Graaf, I. A. M.; Stürup, S.; Groothuis, G. M. M.; Orvig, C.; Casini, A. Ex Vivo Studies on Anticancer Drugs Toxicity and Transport Mechanism in Kidney: Cisplatin vs New Generation Gold-Based Compound. (Manuscript in preparation).
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- Hahn, E. M.; Estrada-Ortiz, N.; Han, J.; Ferreira, V. F. C.; Kapp, T. G.; Correia, J. D. G.; Casini, A.; Kühn, F. E. Functionalization of Ruthenium(II) Terpyridine Complexes with Cyclic RGD Peptides to Target Integrin Receptors in Cancer Cells. Eur. J. Inorg. Chem. 2017, (12), 1667–1672.
- Estrada-Ortiz, N.; Neochoritis, C. G.; Dömling, A. How to Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures. ChemMedChem 2016, 11 (8), 757–772.
- Neochoritis, C. G.; Wang, K.; Estrada-Ortiz, N.; Herdtweck, E.; Kubica, K.; Twarda, A.; Zak, K. M.; Holak, T. A.; Dömling, A. 2,3’-Bis(1’H-Indole) Heterocycles: New p53/MDM2/MDMX Antagonists. Bioorg. Med. Chem. Lett. 2015, 25 (24), 5661–5666.
- Neochoritis, C.; Estrada-Ortiz, N.; Khoury, K.; Dömling, A. Chapter Twelve: p53–MDM2 and MDMX Antagonists. In Annual Reports in Medicinal Chemistry; Desai, M. C., Ed.; Elsevier, 2014; Vol. 49, pp 167–187.
- Estrada-Ortiz, N.; Fernández, D. M. M.; Ortiz, J. B. L.; Fernández, M. E. M. Licania arborea fraction bioactive potential assessment in jurkat and cho-k1 cell lines. Rev. Cuba. Farm. 2016, 50 (4).
- Blandón, L.; Estrada-Ortiz, N.; López, J.; Márquez, M. Esponjas marinas: ¿producción biotecnlogica sostenible?. Rev. Fac. Cienc. 2014, 3 (2), 11–29.
- Estrada-Ortiz, N.; Ortiz, J. B. L.; Márquez, D. M.; Martinez, A.; Fernández, M. E. M. Evaluación citotóxica de fracciones de esponjas marinas del Caribe Colombiano. Rev. Fac. Cienc. 2013, 2 (1), 35– 51.
