• No results found

University of Groningen Development of novel anticancer agents for protein targets Estrada Ortiz, Natalia

N/A
N/A
Protected

Academic year: 2021

Share "University of Groningen Development of novel anticancer agents for protein targets Estrada Ortiz, Natalia"

Copied!
7
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

Development of novel anticancer agents for protein targets

Estrada Ortiz, Natalia

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Estrada Ortiz, N. (2017). Development of novel anticancer agents for protein targets. University of

Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

DEVELOPMENT OF NOVEL ANTICANCER AGENTS

FOR PROTEIN TARGETS

N

ATALIA

E

STRADA

O

RTIZ

(3)

Paranimphs:

Constantinos Neochoritis Viktoriia Starokozhko

Cover design: Felipe Uribe Morales Layout design: Natalia Estrada Ortiz Printed by: Ipskamp printing

The research presented in this thesis was financially supported by the Department of Science, Technology and Innovation of the Colombian Government (Colciencias). Printing of this thesis was supported by the University of Groningen, Faculty of Science and Engineering and the University Library.

ISBN (printed version): 978-94-034-0142-3 ISBN (digital version): 978-94-034-0141-6

No parts of this thesis may be reproduced or transmitted in any form or any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system, without permission of the author

(4)

Development of Novel Anticancer

Agents for Protein Targets

PhD thesis

to obtain the degree of doctor at the University of Groningen under the authority of the rector Magnificus Prof. Dr. E. Sterken

and in accordance with the decision by the College of Deans. The public defense will take place on Friday 20 October 2017 at 16.15 hours

by

Natalia Estrada Ortiz

born August 17, 1985 in Medellin, Colombia

(5)

Supervisors

Prof. A.S.S. Dömling Prof. G.M.M. Groothuis Prof. A. Casini Assessment Committee Prof. F.J. Dekker Prof. P. Olinga Prof. R.J. Pieters

(6)

dƒ½›Ê¥‘ÊÄã›ÄãÝ

,WdZϭ

'›Ä›Ùƒ½/ÄãÙʗç‘ã®ÊÄ

ϭ

,WdZϮ

®Ã݃ėÊç㽮ěÊ¥㫛㫛ݮÝ

ϭϵ



WZd

/Ä«®®ãÊÙÝÊ¥WϱϯͬD—ÃϮ/Äã›Ùƒ‘ã®ÊÄ

,WdZϯ

,ÊóãÊ—›Ý®¦ÄƒÝ瑑›ÝÝ¥ç½ÖϱϯͲ×ÃϮͬø®Ä«®®ãÊÙ͗

Ϯϱ



ƒã«ÊÙÊ禫Êò›Ùò®›óƒÝ›—ÊÄ‘ÙùÝヽÝãÙç‘ãçٛÝ

,WdZϰ

Ù㮥®‘®ƒ½ÑÙʑù‘½›ÝƒÝÖÊã›ÄãÖϱϯͲ×ÃϮ®Ä«®®ãÊÙÝ ϱϱ

,WdZϱ

Ϯ͕ϯ͛Ͳ®Ý;ϭ͛«Ͳ®Ä—ʽ›Ϳ,›ã›Ùʑù‘½›Ý͗

ϭϬϵ



E›óÖϱϯͬ×ÃϮͬ×ÃøÄユÊÄ®ÝãÝ

WZd

®Ê½Ê¦®‘ƒ½‘ã®ò®ãùÊ¥sƒÙ®ÊçÝ&ƒÃ®½®›ÝÊ¥D›ãƒ½



ÊÃÖ½›ø›Ý

,WdZϲ

'ʽ—;®Ϳ‘ÊÃÖ½›ø›Ýó®ã«½ƒÄÝÊÖكþʽ›Ͳãù֛½®¦ƒÄ—Ý͗

ϭϰϱ



›øò®òÊãÊø®‘ʽʦ®‘ƒ½›òƒ½çƒã®ÊÄ

,WdZϳ

E›ó/ÄÝ®¦«ãÝ®ÄãÊ㫛dÊø®‘®ãùƒÄ—dكÄÝÖÊÙã

ϭϲϭ



D›‘«ƒÄ®ÝÃÝÊ¥®ÝÖ½ƒã®Ä®Ä»®—Ä›ù®Ä‘ÊÃփٮÝÊÄ



ãʃ¦Ê½—ͲƒÝ›—ƒÄ㮑ƒÄ‘›Ùƒ¦›Äã

,WdZϴ

Ä㮑ƒÄ‘›Ù¦Ê½—ÄͲ«›ã›Ùʑù‘½®‘‘ƒÙ›Ä›‘ÊÃÖ½›ø›Ý͗ ϭϴϯ



ƒ‘ÊÃփكã®ò›®Äò®ãÙʃė›øò®òÊÝãç—ù

,WdZϵ

^çÃÃÙùƒÄ—®Ý‘çÝÝ®ÊÄ

Ϯϭϱ



;E›—›Ù½ƒÄ—Ý›^ƒÃ›Äòƒãã®Ä¦Ϳ

ϮϮϱ

WWE/y



‘»ÄÊ󽛗¦›Ã›ÄãÝ

Ϯϯϵ



Êçã㫛çã«ÊÙ

Ϯϰϭ

(7)

Referenties

GERELATEERDE DOCUMENTEN

Additionally, a series of gold complexes were studied to understand their possible mechanism of action compared with cisplatin, including cancer cell based studies and healthy

The cytotoxic activities of the compounds were tested in 4 human cancer cell lines and their toxicity in healthy tissue was determined using rat precision cut kidney slices as a

Crystal structure of compound 3 (WK23) bound to MDM2 (PDB: 3LBK): A hydrogen bond between the indole N-H of 3 and the MDM2 Leu54 carbonyl oxygen is depicted.. The

The organic layer was separated, washed with water, dried over anhydrous MgSO 4 and evaporated, affording the corresponding compounds 1 (yields 11-ϳϬйͿ. as a

To a stirred solution of the corresponding compounds 2 (1.0 mmol) in EtOH-water (1:1), LiOH (10.0 mmol) was added and the reaction mixture refluxed overnight.. Then, pH was adjusted

In the present study, the potential selectivity of these compounds was studied in an ex-vivo model, using rat precision cut kidney and liver slices (PCKS and PCLS), to determine

However, slices treated with cisplatin at 100 μM showed significant differences at 30 and 60 min, with a lower Pt content in the slices incubated at 4°C compared to 37°C,

Due to their potent cytotoxic effects in cancer cells, complexes 1-4 were tested for their possible toxicity in an ex vivo model in healthy rat kidney tissue using the