University of Groningen
Brain and retinal macro- and microvasculature
Li, Youhai
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Publication date: 2018
Link to publication in University of Groningen/UMCG research database
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Li, Y. (2018). Brain and retinal macro- and microvasculature: Response to ischemic and hyperglycemic stress. University of Groningen.
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Stellingen behorende bij het proefschrift
Brain and retinal macro- and
microvasculature
Response to ischemic and hyperglycemic stress
1. After cerebral ischemia application of bradykinin to the middle cerebral arteries induces a de novo concentration-dependent relaxation via B2 receptor activation within endothelial cells (this thesis).
2. The activation of B2 receptors triggers the release of nitric oxide (NO) and endothelium-dependent hyperpolarization (this thesis).
3. In vertebrate embryonic development, the retina originates from the developing brain and its microvascular network shares, in many aspects, similar features with the cerebral microvascular network (this thesis).
4. The microvasculature in retina is highly susceptible to diabetic insult, whereas the microvasculature in brain appears to be not or significantly less susceptible to diabetes (this thesis).
5. Most theories on the pathogenesis of diabetic microvascular complications are based on studies using hyperglycemia-susceptible vascular beds, e.g. the retinal vascular bed. However, this does not explain why the brain microvasculature which shares similar anatomical and physiological properties with the retinal microvasculature, is not or significantly less susceptible to diabetes (this thesis). 6. In diabetes, protective mechanisms for the brain microvasculature were identified,
such as reduction of glycolytic intermediates, reduction of ROS production and enlarged anti-inflammatory capacity, whereas these defense systems were not activated or even suppressed in the retinal microvasculature (this thesis).
7. If you want to prevent vision loss, ask help from your brain. 8. Anyone can hold the truth when the brain is calm.
9. Das schönste Glück des denkenden Menschen ist, das Erforschliche erforscht zu haben und das Unerforschliche zu verehren (Johann Wolfgang von Goethe).
