University of Groningen
Methylation analysis for the identification of cervical lesions to improve cervical cancer screening in a Chinese population
Li, Na
DOI:
10.33612/diss.134442856
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Publication date: 2020
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Citation for published version (APA):
Li, N. (2020). Methylation analysis for the identification of cervical lesions to improve cervical cancer screening in a Chinese population. University of Groningen. https://doi.org/10.33612/diss.134442856
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Methylation analysis for the identification of cervical lesions
to improve cervical cancer screening in a Chinese population
Na Li 李娜
Ph.D. thesis University of Groningen, the Netherlands
Cover image: download from http://699pic.com/ Cover design: Na Li & Guopeng Jia
Cover layout: Ipskamp-The Netherlands Text Layout: Na Li & Guopeng Jia Printed by: Ipskamp-The Netherlands
Copyright © Na Li, 2020. All rights reserved. No part of this thesis may be reproduced, stored
in a retrieval system, or transmitted in any form or by any means, without prior permission of the author and publisher holing the copyright of the published articles.
The research in this thesis was supported by the Open Fund of Tianjin Central Hospital of Gynecology Obstetrics/Tianjin Key Laboratory of human development and reproductive regulation (2019XH06) and by a sandwich PhD scholarship funded by the Abel Tasman Talent Program of the Graduate School of Medical Sciences of the University Medical Center Groningen/University of Groningen, The Netherlands.
The publication of this thesis was supported by the Graduate School of Medical Sciences of the University of Groningen, University Medical Centrum Groningen.
Methylation analysis for the
identification of cervical lesions to
improve cervical cancer screening in
a Chinese population
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Wednesday 21 October 2020 at 14.30 hours
by
Na Li
born on 16 September 1982
Supervisors
Prof. A.G.J. van der Zee Prof. E. Schuuring
Co-supervisor
Dr. G.B.A. WismanAssessment Committee
Prof. H.W. Nijman Prof. H. Hollema Prof. R.D.M. SteenbergenParanymphs
Pei MengDedicated to My family
Contents
Chapter 1 General Introduction ... 9
Chapter 2 DNA methylation markers as triage test for the early identification of cervical lesions in a Chinese population ... 27
Submitted for publication Chapter 3 DNA methylation markers for triaging high-risk human papilloma virus-positive women in early cervical cancer screening: a systematic review ... 51
Submitted for publication Chapter 4 ZNF582 methylation as a potential biomarker to predict cervical intraepithelial neoplasia type III/worse: A meta-analysis of related studies in Chinese population ... 85
Medicine (Baltimore). 2019.Feb;98(6):e14297. Chapter 5 PAX1 and ZNF582 methylation analysis and improvement of cervical cancer screening... 103
Manuscript in preparation Chapter 6 Summary ... 129
Chapter 7 General Discussion and future perspectives ... 135
Chapter 8 Chinese summary ... 155
Nederlandse samenvatting (Dutch summary) ... 159
Curriculum vitae ... 166
List of publications ... 167