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University of Groningen Methylation analysis for the identification of cervical lesions to improve cervical cancer screening in a Chinese population Li, Na

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University of Groningen

Methylation analysis for the identification of cervical lesions to improve cervical cancer screening in a Chinese population

Li, Na

DOI:

10.33612/diss.134442856

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Li, N. (2020). Methylation analysis for the identification of cervical lesions to improve cervical cancer screening in a Chinese population. University of Groningen. https://doi.org/10.33612/diss.134442856

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Methylation analysis for the identification of cervical lesions

to improve cervical cancer screening in a Chinese population

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Na Li 李娜

Ph.D. thesis University of Groningen, the Netherlands

Cover image: download from http://699pic.com/ Cover design: Na Li & Guopeng Jia

Cover layout: Ipskamp-The Netherlands Text Layout: Na Li & Guopeng Jia Printed by: Ipskamp-The Netherlands

Copyright © Na Li, 2020. All rights reserved. No part of this thesis may be reproduced, stored

in a retrieval system, or transmitted in any form or by any means, without prior permission of the author and publisher holing the copyright of the published articles.

The research in this thesis was supported by the Open Fund of Tianjin Central Hospital of Gynecology Obstetrics/Tianjin Key Laboratory of human development and reproductive regulation (2019XH06) and by a sandwich PhD scholarship funded by the Abel Tasman Talent Program of the Graduate School of Medical Sciences of the University Medical Center Groningen/University of Groningen, The Netherlands.

The publication of this thesis was supported by the Graduate School of Medical Sciences of the University of Groningen, University Medical Centrum Groningen.

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Methylation analysis for the

identification of cervical lesions to

improve cervical cancer screening in

a Chinese population

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the

Rector Magnificus Prof. C. Wijmenga and in accordance with

the decision by the College of Deans. This thesis will be defended in public on Wednesday 21 October 2020 at 14.30 hours

by

Na Li

born on 16 September 1982

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Supervisors

Prof. A.G.J. van der Zee Prof. E. Schuuring

Co-supervisor

Dr. G.B.A. Wisman

Assessment Committee

Prof. H.W. Nijman Prof. H. Hollema Prof. R.D.M. Steenbergen

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Paranymphs

Pei Meng

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Dedicated to My family

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Contents

Chapter 1 General Introduction ... 9

Chapter 2 DNA methylation markers as triage test for the early identification of cervical lesions in a Chinese population ... 27

Submitted for publication Chapter 3 DNA methylation markers for triaging high-risk human papilloma virus-positive women in early cervical cancer screening: a systematic review ... 51

Submitted for publication Chapter 4 ZNF582 methylation as a potential biomarker to predict cervical intraepithelial neoplasia type III/worse: A meta-analysis of related studies in Chinese population ... 85

Medicine (Baltimore). 2019.Feb;98(6):e14297. Chapter 5 PAX1 and ZNF582 methylation analysis and improvement of cervical cancer screening... 103

Manuscript in preparation Chapter 6 Summary ... 129

Chapter 7 General Discussion and future perspectives ... 135

Chapter 8 Chinese summary ... 155

Nederlandse samenvatting (Dutch summary) ... 159

Curriculum vitae ... 166

List of publications ... 167

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