University of Groningen
Heart failure biomarkers: The importance of cardiac specificity
Piek, Arnold
DOI:
10.33612/diss.146698618
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Publication date:
2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Piek, A. (2020). Heart failure biomarkers: The importance of cardiac specificity. University of Groningen.
https://doi.org/10.33612/diss.146698618
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Stellingen behorende bij het proefschrift
Heart failure biomarkers: The importance of cardiac specificity
Arnold Piek
1. Knowledge of tissue origin and function is necessary to identify the role of a plasma biomarker – This thesis
2. The number of clinical biomarker association studies is overwhelming, but most of them are of limited value without further mechanistic evaluation –
This thesis
3. Plasma levels of cardiac specific markers (natriuretic peptides) correlate with indices of cardiac remodeling, whilst plasma levels of non-cardiac specific biomarkers (Gal-3, GDF-15 and TIMP-1) do not – This thesis
4. Stressed and injured peripheral tissues in heart failure are responsible for elevated plasma levels of several non-cardiac specific biomarkers – This thesis 5. Plasma levels of HE4 and DKK3 correlate with heart failure severity, but are also strongly associated with comorbidities and kidney function – This thesis 6. Considering the cardiac specific expression of the secreted BMP10 protein, it
may have similar biomarker potential as the natriuretic peptides – This thesis 7. Pharmacological inhibition of MPO attenuates heart failure comorbidities, but
does not exert direct effects on cardiac remodeling – This thesis
8. In general, a diagnostic biomarker of disease should be highly organ/tissue specific. For a prognostic biomarker this is not a prerequisite
9. Pharmacological targeting of non-cardiac specific biomarkers can result in both cardiac but also peripheral (side) effects
