University of Groningen
Heart failure biomarkers: The importance of cardiac specificity Piek, Arnold
DOI:
10.33612/diss.146698618
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Publication date: 2020
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Piek, A. (2020). Heart failure biomarkers: The importance of cardiac specificity. University of Groningen. https://doi.org/10.33612/diss.146698618
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Heart failure biomarkers: The
importance of cardiac specificity
© 2020 Arnold Piek
If published, copyright of each chapter is with the publisher of the journal in which the work has been published. Otherwise, copyright is with the author of this thesis. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without prior permission from the author or when applicable from the publisher of the specific published articles.
ISBN: 978-94-6416-218-9 Cover illustration: Karin Piek Layout: Arnold Piek
Printing: Ridderprint
Financial support by the Graduate School of medical Sciences (University of Groningen) for the publication of this thesis is gratefully acknowledged.
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Heart failure biomarkers: The
importance of cardiac specificity
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 9 december 2020 om 16.15 uur
door
Arnold Piek
geboren op 3 mei 1993 te Groningen
Promotores
Prof. dr. H.H.W. Sillje Prof. dr. R.A. de Boer
Beoordelingscommissie
Prof. dr. A.J.A. van de Sluis Prof. dr. A.A. Voors
Prof. dr. C.E. Mueller
Paranimfen
K. Piek, MSc N.M. Stege, MSc
TABLE OF CONTENTS
Chapter 1 Introduction 7
Chapter 2 The fibrosis-cell death axis in heart failure 17
Heart Fail Rev. 2016 Mar;21(2):199-211
Chapter 3 HE4 serum levels are associated with heart failure 39
severity in patients with chronic heart failure
J Card Fail. 2017 Jan;23(1):12-19
Chapter 4 Novel heart failure biomarkers: Why do we fail to exploit 55
their potential?
Crit Rev Clin Lab Sci. 2018 Jun;55(4):246-263
Chapter 5 Plasma levels of heart failure biomarkers are 85
primarily a reflection of extracardiac production
Theranostics. 2018 Jul;8(15):4155-4169
Chapter 6 A combined bioinformatics, experimental and clinical 121
approach to identify novel cardiac specific heart failure
biomarkers: Is Dickkopf-3 (DKK3) a possible candidate?
Eur J Heart Fail. 2020 Aug. doi 10.1002/ejhf.1988
Chapter 7 The emerging plasma biomarker Dickkopf-3 (DKK3) and 159
its association with renal and cardiovascular disease in
the general population
Manuscript in submission
Chapter 8 Pharmacological myeloperoxidase (MPO) inhibition in 175
an obese/hypertensive mouse model attenuates obesity
and liver damage, but not cardiac remodeling
Sci Rep. 2019 Dec;9(1):18765
Chapter 9 Summary, discussion and future perspectives 201
Appendices 219
Dutch summary 221
Curriculum vitae 237
