University of Groningen
Non-cardiac comorbidities in heart failure with preserved ejection fraction
Streng, Koen Wouter
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Streng, K. W. (2019). Non-cardiac comorbidities in heart failure with preserved ejection fraction: Focussing
on obesity and renal dysfunction. University of Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Non-cardiac Comorbidities in Heart
Failure with Preserved Ejection
Fraction
Focussing on obesity and renal dysfunction
Koen W. Streng
The financial support of the Graduate School of Medical Sciences and the University of Groningen for the publication of this thesis is gratefully acknowledged.
Lay-out and printing by: Optima Grafische Communicatie ISBN: 978-94-6361-277-7
Non-cardiac Comorbidities in Heart Failure with Preserved Ejection Fraction Focussing on obesity and renal dysfunction
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 12 juni 2019 om 14.30 uur
door
Koen Wouter Streng geboren op 5 november 1988
te Apeldoorn
2
Non-cardiac Comorbidities in Heart
Failure with Preserved Ejection
Fraction
Focussing on obesity and renal dysfunction
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 12 juni 2019 om 14.30 uur
door
Koen Wouter Streng
geboren op 5 november 1988 te Apeldoorn
Promotores Prof. dr. A.A. Voors Prof. dr. J.L. Hillege
Copromotor Dr. K. Damman
Beoordelingscommissie Prof. dr. M.C. Verhaar Prof. dr. R.A. de Boer Prof. dr. M.P. van den Berg
Paranimfen Mw. B.T. Santema Dhr. J.F. Nauta
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged. The research described in this thesis was supported by a grant of the Dutch Heart Foundation (2014B011 CVON RECONNECT)
Table of Contents
Chapter 1 Introduction 9
Chapter 2 Non-cardiac comorbidities in heart failure with reduced, mid-range and preserved ejection fraction
19
Chapter 3 Associations of body mass index with laboratory and biomarkers in patients with acute heart failure
41
Circ Heart Fail 2017;10:e003350
Chapter 4 Waist-to-hip ratio and mortality in heart failure 67
Chapter 5 Clinical implications of low estimated protein intake in patients with heart failure
89
Submitted
Chapter 6 Renin-angiotensin system inhibition, worsening renal function, and outcome in heart failure patients with reduced and preserved ejection fraction: a meta-analysis of published study data
109
Circ Heart Fail 2017;10:e003588
Chapter 7 Urinary marker profiles in heart failure with reduced and preserved ejection fraction
133
To be submitted
Chapter 8 Summary and future perspectives 153
Appendices
Dutch summary | Nederlandse samenvatting 169 Acknowledgements | Dankwoord 177
Bibliography 183
