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University of Groningen

Chronic abdominal pain, fatigue and inflammatory bowel disease in children

Van de Vijver, Els

DOI:

10.33612/diss.147541085

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Van de Vijver, E. (2020). Chronic abdominal pain, fatigue and inflammatory bowel disease in children.

University of Groningen. https://doi.org/10.33612/diss.147541085

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1

CHRONIC ABDOMINAL PAIN, FATIGUE

and INFLAMMATORY BOWEL DISEASE in

CHILDREN

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2

The research described in this thesis was performed at the Department of Pediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

The author gratefully acknowledges the financial support for printing this thesis by: Groningen University Institute for Drug Exploration (GUIDE)

University Medical Center Groningen (UMCG) University of Groningen

This thesis is printed by: Ridderprint BV, Ridderkerk, The Netherlands Cover: Ridderprint www.ridderprint.nl

ISBN: 978-94-6416-226-4

3

Chronic abdominal pain, fatigue

and inflammatory bowel disease in

children

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 4 november 2020 om 11.00 uur

door

Els Van de Vijver

geboren op 29 maart 1977 te Wilrijk, België

(4)

2

The research described in this thesis was performed at the Department of Pediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

The author gratefully acknowledges the financial support for printing this thesis by: Groningen University Institute for Drug Exploration (GUIDE)

University Medical Center Groningen (UMCG) University of Groningen

This thesis is printed by: Ridderprint BV, Ridderkerk, The Netherlands Cover: Ridderprint www.ridderprint.nl

ISBN: 978-94-6416-226-4

3

Chronic abdominal pain, fatigue

and inflammatory bowel disease in

children

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 4 november 2020 om 11.00 uur

door

Els Van de Vijver

geboren op 29 maart 1977 te Wilrijk, België

(5)

4 Promotores Prof. dr. H.J. Verkade Dr. P.F. van Rheenen Beoordelingscommissie Prof. dr. J.C. Escher Prof. dr. G. Dijkstra Prof. dr. A.A.E. Verhagen

5

Paranimfen

Anke Heida Nicolette Moes

(6)

4 Promotores Prof. dr. H.J. Verkade Dr. P.F. van Rheenen Beoordelingscommissie Prof. dr. J.C. Escher Prof. dr. G. Dijkstra Prof. dr. A.A.E. Verhagen

5

Paranimfen

Anke Heida Nicolette Moes

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7

CONTENTS

Chapter 1 General introduction and outline of this thesis

Part I -Triage for endoscopy

Chapter 2 Safely ruling out IBD in children and teenagers without referral for endoscopy

Arch Dis Child, 2012, 1014-8.

Chapter 3 Predicting inflammatory bowel disease in children with abdominal pain and diarrhoea: calgranulin-C versus calprotectin stool test

Arch Dis Child, 2018, 565-571

Chapter 4 Test strategies to predict inflammatory bowel disease among children with non-bloody diarrhoea

Pediatrics, 2020, epub ahead of print

Part II - Quality of life beyond clinical remission: fatigue in paediatric IBD

Chapter 5 Fatigue in children and adolescents with inflammatory bowel disease World J Gastroenterol, 2019, 632-643.

Chapter 6 The relationship between self-reported fatigue in children with inflammatory bowel disease and haemoglobin levels and disease activity: a multicentre cross-sectional study

Submission in preparation

Chapter 7 General discussion and future perspectives

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7

CONTENTS

Chapter 1 General introduction and outline of this thesis

Part I -Triage for endoscopy

Chapter 2 Safely ruling out IBD in children and teenagers without referral for endoscopy

Arch Dis Child, 2012, 1014-8.

Chapter 3 Predicting inflammatory bowel disease in children with abdominal pain and diarrhoea: calgranulin-C versus calprotectin stool test

Arch Dis Child, 2018, 565-571

Chapter 4 Test strategies to predict inflammatory bowel disease among children with non-bloody diarrhoea

Pediatrics, 2020, epub ahead of print

Part II - Quality of life beyond clinical remission: fatigue in paediatric IBD

Chapter 5 Fatigue in children and adolescents with inflammatory bowel disease World J Gastroenterol, 2019, 632-643.

Chapter 6 The relationship between self-reported fatigue in children with inflammatory bowel disease and haemoglobin levels and disease activity: a multicentre cross-sectional study

Submission in preparation

Chapter 7 General discussion and future perspectives

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8 9

CHAPTER 1

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