Cover Page
The handle http://hdl.handle.net/1887/66878 holds various files of this Leiden
University dissertation.
Author: Essen, T.H. van
Ocular responses to foreign corneal
and tumor tissue
Ocular responses to foreign corneal and tumor tissue
Thesis, Leiden University Medical Center, the Netherlands Cover image by Lotte van Essen-Santifort
Cover design by Lotte van Essen-Santifort and Herbert van Essen Layout by Herbert van Essen
Printed by Ridderprint BV ISBN: 978-94-6375-076-9
Copyright © 2018 T.H. van Essen, Leiden, the Netherlands
No part of this thesis may be reproduced in any form or by any means without written prermission from the author.
Financial support
The research about the artificial cornea described in this thesis was suported by a grant from Agentschap.nl
Publication of this thesis was supported by
Ocular responses to foreign corneal and tumor tissue
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof.mr.C.J.J.M. Stolker
volgens besluit van het College voor Promoties te verdedigen op donderdag 14 november 2018
klokke 13:45 uur door
Theodorus Huibertus van Essen
Promotores Prof. Dr. M.J. Jager Prof. Dr. G.P.M. Luyten Co-promotor Dr. A. el Ghalbzouri Secretaris Prof. Dr. F.H.J. Claas
Commissie Dr. N.S. Lagali Linköping University, Sweden Prof. Dr. M. de Haas
Dr. M.J.W. Zaal OMC Zaandam, Amsterdam UMC Prof. Dr. C.J.M. Boon
‘The soul becomes dyed with the color of its thoughts’
Marcus Aurelius
CONTENTS
Chapter 1 General introduction 9 Chapter 2 A fish scale-derived collagen matrix as artificial cornea in rats: properties and
potential.
Investigative Ophthalmology and Visual Science 2013; 54:3224-33
29 Chapter 3 Biocompatibility of a fish scale-derived artificial cornea: cytotoxicity, cellular
adhesion and phenotype, and in vivo immunogenicity.
Biomaterials 2016; 81:36-45
51 Chapter 4 Matching for Human Leukocyte Antigens (HLA) in corneal transplantation – to
do or not to do?
Progress Retinal & Eye Research 2015; 46:84-110
75 Chapter 5 A comparison of HLA genotype with inflammation in uveal melanoma.
Investigative Ophthalmology and Visual Science 2012; 53:2640-6
131 Chapter 6 Upregulation of HLA expression in primary uveal melanoma by infiltrating
leukocytes.
PLoS One. 2016; 20;11(10):e0164292
147 Chapter 7 Prognostic parameters in uveal melanoma and their association with BAP1
expression.
British Journal Ophthalmology 2014; 98:1738-43
175 Chapter 8 Summary and general discussion 191 Acknowlegdements (Dankwoord) 201
Curriculum Vitae 207
