Cover Page
The handle
http://hdl.handle.net/1887/136020
holds various files of this Leiden University
dissertation.
Author: Schrader, A.M.R.
DIAGNOSTIC AND PROGNOSTIC MARKERS
OF CUTANEOUS LYMPHOMAS
Anne Marije Rosa Schrader
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Diagnosti c and prognosti c markers of cutaneous lymphomas Thesis, University of Leiden, Leiden, The Netherlands ISBN 978‑94‑6375‑982‑3
Design: Floris Schrader | www.fl oos.nl
Layout: Lara Leijtens | www.persoonlijkproefschrift .nl Print: Ridderprint | www.ridderprint.nl
Printi ng of this thesis was fi nancially supported by Kyowa Kirin Pharma B.V. Copyright © 2020, Anne Marije Rosa Schrader, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored, or transmitt ed without prior permission of the author.
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Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 27 augustus 2020 klokke 15:00 uur
door
Anne Marije Rosa Schrader
geboren te Groningen in 1985
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Promotores Prof. dr. R. Willemze Prof. dr. M.H. Vermeer Co-promotor Dr. P.M. Jansen Leden promotiecommissie Prof. dr. V.T.H.B.M. Smit
Prof. dr. M.R. van Dijk (Universitair Medisch Centrum Utrecht) Dr. L. Koens (Amsterdam Universitair Medisch Centrum, locatie AMC)
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CONTENTS
Chapter 1 General introduction 6
Chapter 2 TOX expression in cutaneous T‑cell lymphomas 24
Chapter 3 TOX expression in cutaneous B‑cell lymphomas 38
Chapter 4 No TP63 rearrangements in a selected group of primary
cutaneous CD30+ lymphoproliferative disorders with
aggressive clinical course
50
Chapter 5 High incidence and clinical significance of MYC
rearrangements in primary cutaneous diffuse large B‑cell lymphoma, leg type
60
Chapter 6 Persistent oncogenic pathways drive primary cutaneous
diffuse large B‑cell lymphoma, leg type and their relapses
80
Chapter 7 High prevalence of MYD88 and CD79B mutations in
intravascular large B‑cell lymphoma
108
Chapter 8 Summary and discussion 124
Appendices List of abbreviations 140
CHAPTER
GENERAL
INTRODUCTION
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