Cutaneous B-cell lymphoma : classification, prognostic factors and management recommendations
Senff, N.J.
Citation
Senff, N. J. (2009, February 12). Cutaneous B-cell lymphoma : classification, prognostic factors and management recommendations. Retrieved from
https://hdl.handle.net/1887/13473
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Cutaneous B-cell lymphoma:
classification, prognostic factors and management recommendations
Nancy J. Senff
The studies described in this thesis were financially supported by a grant from the Dutch Cancer Society (UL 2006-3705) (Chapters 2 and 3).
Publication of this thesis was financially supported by:
Cephalon B.V., Astellas B.V., Fagron B.V., Beiersdorf NV, Merck Serono B.V., Jansen- Cilag B.V., LEO Pharma B.V., ABBOTT B.V., Bauerfeind Benelux B.V., Galderma en Wyeth Pharmaceuticals B.V.
Cover design: Patrick Maidman Printed by PrintPartners Ipskamp
Cutaneous B-cell lymphoma: classification, prognostic factors and management recommendations
Copyright © 2009, Nancy Johanna Senff, The Netherlands
No part of this thesis may be reproduced, stored or transmitted without prior permission of the author.
Cutaneous B-cell lymphoma:
classification, prognostic factors and management recommendations
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 12 februari 2009 klokke 16.15 uur
door
Nancy Johanna Senff geboren te Arnhem
in 1977
Promotiecommissie
Promotor: Prof. Dr. R. Willemze
Co-promotores: Dr. C.P. Tensen Dr. M.H. Vermeer
Referent: Prof. Dr. J.H.J.M. van Krieken, Radboud Universiteit, Nijmegen
Overige leden: Prof. Dr. C.J.L.M. Meijer, Vrije Universiteit, Amsterdam Prof. Dr. E.M. Noordijk
Prof. Dr. R. Willemze
Dr. P.M. Jansen
C’est le temps que tu as perdu pour ta rose qui fait ta rose si importante.
Uit: “Le petit prince”
Antoine de Saint-Exupéry (1900-1944)
Voor Philippe
Contents
List of abbreviations 9
Chapter 1 General Introduction 11
Chapter 2 Reclassification of 300 primary cutaneous B-cell 31 lymphomas according to the new WHO-EORTC
classification for cutaneous lymphomas:
comparison with previous classifications and identification of prognostic markers
Journal of Clinical Oncology 2007; 25(12):1581-7
Chapter 3 Fine-mapping chromosomal loss at 9p21: correlation with 47 prognosis in primary cutaneous diffuse large B-cell
lymphoma, leg type
Journal of Investigative Dermatology; in press
Chapter 4 The applicability and prognostic value of the new TNM 63 classification system for primary cutaneous lymphomas other than mycosis fungoides and Sézary syndrome:
results on a large cohort of primary cutaneous B-cell lymphomas and comparison with the system used by the Dutch Cutaneous Lymphoma Group
British Journal of Dermatology 2007; 157(6):1205-11
Chapter 5 Results of bone marrow examination in 275 patients with 75 histological features that suggest an indolent type of
cutaneous B-cell lymphoma
British Journal of Haematology 2008; 142(1):52-6
Chapter 6 Results of radiotherapy in 153 primary cutaneous B-cell 87 lymphomas classified according to the WHO-EORTC
classification
Archives of Dermatology 2007; 143(12):1520-6
Chapter 7 European Organization for Research and Treatment of 101 Cancer (EORTC) and International Society for
Cutaneous Lymphoma (ISCL) consensus recommendations for the management of cutaneous B-cell lymphomas Blood 2008; 112(5):1600-9
Chapter 8 Summary and Discussion 131
Nederlandse samenvatting 147
List of publications 153
Curriculum vitae 157
Nawoord 161
9
List of abbreviations
ABC Activated B-cell
aCGH Array-based comparative genomic hybridization
Bcl-2 B-cell CLL/lymphoma 2
BMB Bone marrow biopsy
CBCL Primary cutaneous B-cell lymphoma cFCL Cutaneous follicle centre lymphoma CTCL Primary cutaneous T-cell lymphoma
DCLG Dutch Cutaneous Lymphoma Group
DLBCL Diffuse large B-cell lymphoma
DSS Disease-specific survival
EMZL Extranodal marginal zone lymphoma
EORTC(-CLG) European Organization for Research and Treatment of Cancer (–
Cutaneous Lymphoma Group)
FL Follicular lymphoma
FOXP1 Forkhead box P1
GCB Germinal centre B-cell
ISCL International Society for Cutaneous Lymphomas
MF Mycosis fungoides
MLPA Multiplex Ligation-dependent Probe Amplification
MUM-1 Multiple myeloma oncogene 1
NHL Non-Hodgkin lymphoma
OS Overall survival
PCFCCL Primary cutaneous follicle centre cell lymphoma PCFCL Primary cutaneous follicle centre lymphoma
PCI Primary cutaneous immunocytoma
PCLBCL-leg Primary cutaneous large B-cell lymphoma of the leg PCLBCL, LT Primary cutaneous diffuse large B-cell lymphoma, leg type PCLBCL, other Primary cutaneous diffuse large B-cell lymphoma, other PCMZL Primary cutaneous marginal zone B-cell lymphoma
RFS Relapse-free survival
RT Radiotherapy
SS Sézary syndrome
WHO World Health Organization
