University of Groningen
Studies on delirium and associated cognitive and functional decline in older surgical patients
Beishuizen, Sara
DOI:
10.33612/diss.135861414
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Beishuizen, S. (2020). Studies on delirium and associated cognitive and functional decline in older surgical patients: The time is now to improve perioperative care and outcomes. University of Groningen.
https://doi.org/10.33612/diss.135861414
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Studies on delirium and associated cognitive
and functional decline in older surgical
patients
The time is now to improve perioperative care and outcomes
Layout Toon Banen
Copyright © 2020 Sara Beishuizen. All rights reserved. No parts of this thesis may be reproduced, stored or transmitted in any way without prior permission of the author.
Studies on delirium and associated cognitive
and functional decline in older surgical
patients
The time is now to improve perioperative care and
outcomes
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 28 oktober 2020 om 14.30 uur
door
Sara Jozien Elzemien Beishuizen
geboren op 10 juni 1987
te Amsterdam
Promotores
Prof. dr. B.C. van Munster
Prof. dr. S.E.J.A. de Rooij
Beoordelingscommissie
Prof. dr. I.E.C. Sommer
Dr. J.H. de Ruiter MBA
Prof. dr. F.U.S. Mattace Raso
Table of contents
Chapter 1: General introduction 6
Part 1: Studies on factors that show a temporal relation with the development of 13 delirium in the perioperative period
Chapter 2: Timing is critical in determining the association between delirium 14 and S100 calcium-binding protein B
Chapter 3: Unraveling the relationship between delirium, brain damage and subsequent 19 cognitive decline in a cohort of individuals undergoing surgery for hip fracture
Chapter 4: The effect of treatment of anemia with blood transfusion on delirium: 35 a systematic review
Chapter 5: The effect of blood transfusion on delirium incidence 68 Part 2: Studies on delirium and its effects on long term cognitive and functional 84 outcome
Chapter 6: Distinct cognitive trajectories in the first year after hip fracture 85 Chapter 7: Delirium, functional decline and quality of life after transcatheter aortic 106 valve implantation: an explorative study
Chapter 8: Summary 120
Chapter 9: General discussion 125
Appendices 137
Nederlandse samenvatting 138
List of co-authors 143
List of publications 145
Dankwoord 147
