VU Research Portal
Development of vector-based strategies against glioblastoma
Crommentuijn, M.H.W.
2017
document version
Publisher's PDF, also known as Version of record
Link to publication in VU Research Portal
citation for published version (APA)
Crommentuijn, M. H. W. (2017). Development of vector-based strategies against glioblastoma.
General rights
Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain
• You may freely distribute the URL identifying the publication in the public portal ?
Take down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
E-mail address:
vuresearchportal.ub@vu.nl
The research presented in this thesis was performed at the Neuro-science Center of Massachusetts General Hospital and Harvard Medical School (Boston), the Cancer Center Amsterdam, depart-ment of Neurosurgery at the VU University Medical Center (Amster-dam), and the department of Bio-Pharmacy/Mouse Cancer Clinic at the Netherlands Cancer Institute (Amsterdam).
Printing of this thesis was financially supported by:
Stichting STOPhersentumoren.nl –www.stophersentumoren.nl
Design & layout: M.H.W. (Thijs) Crommentuijn Compiled using: X E LATEX
ISBN: 978-94-6233-742-8
Printed by: Gildeprint –www.gildeprint.nl
© 2017 – Matheus H. W. Crommentuijn
All rights reserved.
vrije universiteit
Development of vector-based strategies
against glioblastoma
academisch proefschrift
ter verkrijging van de graad Doctor aan de Vrije Universiteit Amsterdam, op gezag van de rector magnificus
prof.dr. V. Subramaniam, in het openbaar te verdedigen ten overstaan van de promotiecommissie
van de Faculteit der Geneeskunde op vrijdag 3 november 2017 om 11.45 uur
in de aula van de universiteit, De Boelelaan 1105
door
Matheus Herman Wilhelmus Crommentuijn
promotor: prof.dr. T. Würdinger copromotoren: dr. D. P. Noske
leescommissie: prof. dr. Pieter Wesseling prof. dr. Victor van Beusechem dr. Piter Bosma
prof. dr. Clemens Dirven prof. dr. Martine Smit dr. Olaf van Tellingen paranimfen: Maaike Hanegraaf
Table of Contents
Chapter 1
General introduction
1
Chapter 2
Intracranial AAV-sTRAIL combined with
lanatoside C prolongs survival in an orthotopic
xenograft mouse model of invasive glioblastoma
47
Chapter 3
Systemically administered AAV9-sTRAIL
combats invasive glioblastoma in a patient-derived
orthotopic xenograft model
67
Chapter 4
Mouse gender influences brain transduction by
intravascularly administered AAV9
89
Chapter 5
Naturally enveloped AAV vectors for shielding
neutralizing antibodies and robust gene delivery
in vivo
103
Chapter 6
Visualizing host–tumor interactions of platelets
and extracellular vesicles in mouse and human
glioblastoma models
137
Chapter 7
General discussion
151
Chapter 8
Summary — Samenvatting
169
Chapter &
Appendix
177
Publications
Curriculum vitae auctoris
