University of Groningen Heartbeat-to-heartbeat cardiac tissue characterization van den Boomen, Maaike

University of Groningen

Heartbeat-to-heartbeat cardiac tissue characterization

van den Boomen, Maaike

DOI:

10.33612/diss.128413796

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Publication date: 2020

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van den Boomen, M. (2020). Heartbeat-to-heartbeat cardiac tissue characterization. University of Groningen. https://doi.org/10.33612/diss.128413796

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Heartbeat-to-Heartbeat

Cardiac Tissue Characterization

Maaike van den Boomen

Boston, USA, 2020

Book cover:An abstract representation of the dynamically acquired septal T2-maps

per heartbeat from a very special study participant.

c

_{Copyright 2020 Maaike van den Boomen}

ISBN: 978-94-034-2702-7

ISBN (e-pub): 978-94-034-2703-4

Published by GVO drukkers & vormgevers B.V. - www.gvo.nl -Ede

The research described in this thesis was partly supported by grants from:

• The Dutch Heart Foundation (DHF) Dekker grant under project number 2016T042;

• The National Institutes of Health under research grants: R01MH116173, R01EB020613, R01EB019437, U01EB025162, P41EB015896, and the shared in-strumentation grants: S10RR023401, S10RR019307, S10RR019254, S10RR023043.

The work described in this thesis was performed in collaboration with:

• Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard-MIT Health Sciences and Technology Devision, Harvard Medical School and Massachusetts Institute of Technology, Boston, USA.

• Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

• Department of Biomedical Engineering, Cell-Matrix Interaction for Cardiovas-cular Tissue Regeneration, Eindhoven University of Technology, Eindhoven, The Netherlands.

Heartbeat-to-Heartbeat

Cardiac Tissue Characterization

PhD thesis

to obtain the degree of PhD at the

University of Groningen

on the authority of the

Rector Magnificus Prof. C. Wijmenga

and in accordance with

the decision by the College of Deans

This thesis will be defended in public on

Monday 6 July 2020 at 18.00 hrs

Maaike van den Boomen

born on 24 March 1991

in Amsterdam

Supervisors

Prof. R.A.J.O. Dierckx Prof. R.H.J.A Slart

Co-supervisors

Dr. R.J.H. Borra Dr. N.H.J. Prakken

Assessment Committee

Prof. M.G. Friedrich Prof. M.A. Mariani Dr. J.R. Polimeni

Contents

Chapter 1: Introduction 1

I

Establishment of cardiac quantitative MRI reference values

7

Chapter 2: Native cardiac T1reference values 9

Chapter 3: Native cardiac T2and T2*reference values 55

II

Translation of novel cardiac MRI methods

133

III

Development and validation of cardiac BOLD MRI

165

Chapter 5: Cardiac BOLD-MRI with GESE-EPI 167

Chapter 6: Cardiac BOLD-MRI in hypertensive patients 189 Chapter 7: Simultaneous multi-slice cardiac BOLD-MRI 205

IV

Development and feasibility of cardiac VAI

219

Summary / Samenvatting 257 Bibliography 265 Biography 325 List of Publications 329 Acknowledgements 331 vii