Cover Page
The handle
http://hdl.handle.net/1887/123180
holds various files of this Leiden
University dissertation.
Author:
Rietveld, I.M.
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ALTERED LEVELS OF
COAGULATION FACTORS
IN BLEEDING AND
THROMBOSIS
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The research described in this thesis was funded by a grant of De Stichting voor de Technische Wetenschappen (STW; grant E-coagulation)
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
ISBN: 978-94-6402-273-5
Design/lay-out: GildePrint, Enschede Print: GildePrint, Enschede
© Inge Rietveld, 2020
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ALTERED LEVELS OF
COAGULATION FACTORS
IN BLEEDING AND
THROMBOSIS
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op donderdag 18 juni 2020
klokke 15.00 uur
door
Inge Rietveld
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Promotor Prof. dr. P.H. Reitsma Copromotor Dr. M.H.A Bos
Leden promotiecommissie Prof. dr. S.C. Cannegieter
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7 19 21 41 43 69 83 97 110 113 120 121 123 124
TABEL OF CONTENTS
Chapter 1 General introduction and outline
PART I: BLEEDING
Chapter 2 APC-resistant factor V restores coagulation in factor XI deficiency
PART II: THROMBOSIS
Chapter 3 High levels of coagulation factors and venous thrombosis risk: strongest association for factor VIII and von Willebrand factor
Chapter 4 Factor V levels and risk of venous thrombosis: The MEGA case-control study
Chapter 5 Elevated coagulation factor levels affect the tissue factor-threshold in thrombin generation
Chapter 6 General discussion
Chapter 7 English summary
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