Cover Page
The handle http://hdl.handle.net/1887/45811 holds various files of this Leiden University dissertation
Author: Graaff, M.A. de
Title: Translational molecular pathology of myxoid liposarcoma and leiomyosarcoma of soft tissue
Issue Date: 2017-02-07
Translational molecular pathology of myxoid liposarcoma and leiomyosarcoma of soft tissue
Marieke Anna de Graaff
Translational molecular pathology of myxoid liposarcoma and leiomyosarcoma of soft tissue.
Cover layout by F.K. de Jong and B. Kleverlaan
Top right picture of myxoid liposarcoma and bottom left picture leiomyosarcoma of soft tissue.
The research described in this thesis was supported by the Liddy Shriver Sarcoma Initiative.
Financial support of this thesis was kindly provided by the Department of Pathology, Leiden University Medical Center.
Layout: Ferdinand van Nispen tot Pannerden, my-thesis.nl Printing: GVO drukkers & vormgevers B.V.
Copyright © 2017, M.A. de Graaff, Leiden, The Netherlands.
ISBN: 978-94-6332-130-3
Translational molecular pathology of myxoid liposarcoma and
leiomyosarcoma of soft tissue
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 7 februari 2017
klokke 13:45 uur
door
Marieke Anna de Graaff
geboren op 12 februari 1986te Haarlem
Promotor
Prof. dr. J.V.M.G. Bovée
Copromotor
Dr. K. SzuhaiLeden promotiecommissie
Prof. dr. A.J. GelderblomProf. dr. M. Debiec-Rychter (University of Leuven, Belgium) Dr. E. Danen
“Nullius in verba”
(Quintus Horatius Flaccus, 20 BC)
Voor mijn ouders
Contents
Chapter 1
General Introduction 9Chapter 2
Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity.Human Pathology. 2013; 44(8): 1597-1604.
37
Chapter 3
A translocation t(6;14) in two cases of leiomyosarcoma:molecular cytogenetic and array-based comparative genomic hybridization characterization.
Cancer Genetics. 2015; 208(11): 537-544.
55
Chapter 4
Inhibition of Bcl-2 family members sensitizes soft tissue leiomyosarcomas to chemotherapy.British Journal of Cancer. 2016; 114(11): 1219-1226.
77
Chapter 5
NY-ESO-1 (CTAG1B) expression in mesenchymal tumors.Modern Pathology. 2015; 28(4): 587-595.
97
Chapter 6
Establishment and characterization of a new human myxoid liposarcoma cell line (DL-221) with the FUS-DDIT3 translocation.Laboratory Investigation. 2016; 96(8): 885-894.
117
Chapter 7
High-throughput screening of myxoid liposarcoma cell lines reveals survivin as novel druggable target.Submitted
143
Chapter 8
Summary and concluding remarks 165Chapter 9
Nederlandse samenvatting 175Chapter 10
Curriculum vitae 185List of publications 188
