Citation
Willems, S. M. (2011, February 9). Molecular genetic aspects and
characterization of the extracellular matrix of myxoid tumours of soft tissue.
Retrieved from https://hdl.handle.net/1887/16452
Molecular genetic aspects and characterization of the extracellular
matrix of myxoid tumours of soft tissue
Molecular genetic aspects and characterization of the extracellular matrix of myxoid tumours of soft tissue
Proefschrift
ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof.mr. P.E. van der Heijden,
volgens besluit van het College van Promoties te verdedigen op woensdag 9 februari 2011
klokke 16:15 uur
door
Stefan Martin Willems
Geboren te Brunssum In 1979
Dr. L.A. McDonnell
Prof. Dr. med. habil. T. Mentzel
(University of Freiburg, Freiburg, Germany) Prof. Dr. R. Sciot
(University of Leuven, Leuven, Belgium) Prof. Dr. R.A.E.M. Tollenaar
Prof. Dr. B. van de Water
Contents
Chapter 1: General introduction
Chapter 2: Running GAGs: myxoid matrix in tumor pathology revisited.
What's in it for the pathologist? Virchows Arch 2010; 456(2):181-92.
Chapter 3: Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model. Mod Pathol 2006; 19 (3): 407-16.
Chapter 4: Myxoid tumours of soft tissue: the so-called myxoid extracellular matrix is heterogeneous in composition. Histopathology 2008; 52 (4): 465-74.
Chapter 5: Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix. J Cell Mol Med 2009; 13(7): 1291-301.
Chapter 6: Imaging mass spectrometry of myxoid sarcomas identifies proteins and lipids specific to tumour type and grade, and reveals biochemical intratumour heterogeneity. J Pathol 2010; 222 (4): 400-9.
Chapter 7: Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option. Mol Cancer 2010; 23 (9): 257.
Chapter 8: Discussion
Chapter 9: Nederlandse samenvatting
Curriculum vitae List of publications Nawoord
Aan mijn ouders
