University of Groningen
Genetic susceptibility for inflammatory bowel disease across ethnicities and diseases
van Sommeren, Suzanne
DOI:
10.33612/diss.100597247
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van Sommeren, S. (2019). Genetic susceptibility for inflammatory bowel disease across ethnicities and
diseases. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.100597247
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Stellingen behorende bij het proefschrift
Genetic Susceptibility for Inflammatory Bowel Disease across ethnicities and diseases
1. Identifying an increasing number of genetic risk loci for inflam-matory bowel disease hardly increases the explained disease va-riance, but contributes to biological insights (this thesis). 2. The majority of genetic risk loci for inflammatory bowel disease
are shared across populations, with a few exceptions, for example
NOD2 and ATG16L1 (this thesis).
3. To take into account the influence of ethnicity and certain sub-phenotypes of inflammatory bowel disease in genetic association studies, individuals under study should be deeply phenotyped (this thesis).
4. The shared pathogenesis of inflammatory bowel disease and its extra-intestinal manifestations is underscored by overlapping genetic associations and biological pathways (this thesis). 5. Gene co-expression networks and protein-protein interactions
of candidate genes residing in associated disease loci pinpoint shared biological pathways between inflammatory bowel disease and its extra-intestinal manifestations (this thesis).
6. The shared genetic risk loci between inflammatory bowel disease and gastro-intestinal graft-versus-host disease suggests possibi-lities for drug repositioning (this thesis).
7. Gene expression studies should take cell-type specificity into account (this thesis).
