University of Groningen
Pharmacokinetics and pharmacodynamics of intrathecal baclofen therapy
Heetla, Herre Wigger
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Publication date: 2018
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Heetla, H. W. (2018). Pharmacokinetics and pharmacodynamics of intrathecal baclofen therapy. Rijksuniversiteit Groningen.
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Pharmacokinetics and Pharmacodynamics
of Intrathecal Baclofen Therapy
Printing of the thesis was financially supported by: University of Groningen, University Medical Center Groningen (UMCG).
Colofon
Layout & cover design: Design Your Thesis, www.designyourthesis.com Printing: Ridderprint BV, www.ridderprint.nl
ISBN (printed version): 978-94-6299-857-5 ISBN (electronic version): 978-94-034-0443-1
© 2018 Herre Wigger Heetla, The Netherlands
All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means without written permission of the author and the publisher holding the copyright of the published articles.
Pharmacokinetics and Pharmacodynamics
of Intrathecal Baclofen Therapy
P R O E F S C H R I F T
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
maandag 26 maart 2018 om 16.15 uur
door
Herre Wigger Heetla
geboren op 20 mei 1982 te Groningen
Promotores
Prof. dr. T. van Laar Prof. dr. R.J.M. Groen Prof. dr. M.J. Staal † Copromotor Dr. J.H. Proost Beoordelingscommissie Prof. dr. J.H.B. Geertzen Prof. dr. S.M. Peerdeman Prof. dr. J.M.A. van Gerven
In dankbare herinnering
Prof. dr. M.J. Staal
TABLE OF CONTENTS
Chapter 1. General introduction and outline 9 Chapter 2. Clinical relevance of pharmacological and physiological data in
intrathecal baclofen therapy
Archives of Physical Medicine and Rehabilitation (2014), 95: 2199-2206
23
Chapter 3. Incidence and management of tolerance in intrathecal baclofen therapy Spinal Cord (2009), 47: 751–756
47
Chapter 4. Tolerance to continuous intrathecal baclofen infusion can be reversed by pulsatile bolus infusion
Spinal Cord (2010), 48: 483–486
63
Chapter 5. A pharmacokinetic–pharmacodynamic model for intrathecal baclofen in patients with severe spasticity
British Journal of Clinical Pharmacology (2015), 81:1: 101–112
75
Chapter 6. Improved gait performance in a patient with HSP after a continuous ITB test infusion and subsequent pump implantation
Archives of Physical Medicine and Rehabilitation (2015), 96: 1166-9
103
Chapter 7. The usefulness of qualitative and quantitative tests in measuring the effect of a continuous ITB test-infusion in ambulatory patients with spasticity
Submitted for publication
113
Chapter 8. Summary and discussion 127
Chapter 9. Nederlandse samenvatting 141 Appendices List of abbreviations
Dankwoord Curriculum vitae List of publications 151 153 155 157
