University of Groningen Development of Novel Covalent Inhibitors and Other Scaffolds Through Multicomponent Reactions Sutanto, Fandi

University of Groningen

Development of Novel Covalent Inhibitors and Other Scaffolds Through Multicomponent

Reactions

Sutanto, Fandi

DOI:

10.33612/diss.133643092

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Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Sutanto, F. (2020). Development of Novel Covalent Inhibitors and Other Scaffolds Through Multicomponent Reactions. University of Groningen. https://doi.org/10.33612/diss.133643092

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PROPOSITIONS

for the thesis

Development of Novel Covalent Inhibitors and Other Scaffolds Through Multicomponent Reactions

Fandi Sutanto

1. Multicomponent reaction (MCR) is one of the greatest discoveries in chemistry.

2. The numerous advantages of covalent inhibitors may lead them toward the future of medications, and MCR simplifies the (usually) lengthy synthesis of covalent inhibitors.

3. Instead of using ammonia surrogate, ammonia itself might be a better choice.

4. Automated, high-throughput synthesis, and MCR accelerate the discovery of drug candidates. 5. The bis-heterocycles of tetrazole– and 1,3,4-oxadiazole– linked imidazo[1,5-a]pyridines are

valuable scaffolds in the field of medicinal chemistry.

6. We should aim for projects which are “low-hanging fruits” and get the best of them before everyone else does.

7. Experience is the best teacher.

8. “Insanity is doing the same thing over and over again and expecting different results.” [Albert Einstein]