• No results found

The generation of cytotoxic T cell epitopes and their generation for cancer immunotherapy

N/A
N/A
Protected

Academic year: 2021

Share "The generation of cytotoxic T cell epitopes and their generation for cancer immunotherapy"

Copied!
9
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

The generation of cytotoxic T cell epitopes and their generation for cancer immunotherapy

Kessler, J.

Citation

Kessler, J. (2009, October 27). The generation of cytotoxic T cell epitopes and their generation for cancer immunotherapy. Retrieved from https://hdl.handle.net/1887/14260

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/14260

Note: To cite this publication please use the final published version (if applicable).

(2)

The generation of cytotoxic T cell epitopes and

   

for cancer

immunotherapy

(3)
(4)

The generation of cytotoxic T cell epitopes and

       

Proefschrift

ter verkrijging van de graad van Doctor aan de Universiteit Leiden,           

  ! "    

te verdedigen op dinsdag 27 oktober 2009

# ##$%$&

door Jan Kessler

!  '  $(&(

(5)

The studies presented in this thesis were performed at the department of Immunohematology )    * +  " -. 

    /  !1 " 3 456# #-

! : 3  ; -1 " 3      

!

Promotiecommissie

      1"<

=   1<) 4+  ' :

    1<)'>  

    15  

    1<<.?  

    1@<<64+ + :

    163  4+ + :

A"    <5BCC(

(6)

The real voyage of discovery is not in seeking new landscapes but in having new eyes.

   $EF$G$(BB

  

Beautiful are the things we see, More beautiful those we understand, Much the most beautiful are those we do not comprehend.

.  3 $%HEG$%E%

Danish anatomist and geologist, and bishop

(7)
(8)

Contents

Chapter 1 page 11

Background and scope of the thesis

Published (in part) in Leukemia 21:1859-1874, 2007

" B  %H

@N       *'G'CBC$G    O -

   /O   '@

!   G   

J. Exp. Med. 193:73-88, 2001

" H  E$

1       "1E+-    '@Q

  -G  

Clin. Cancer Res. 12:3130-3136, 2006

Chapter 4 page 91

"  G!   !     $H  

*'  S  V   G !  

Hum. Immunol. 64:245-255, 2003

" &  $C&

)"G')*       #   

"1E+-  

Leukemia 20:1738-1750, 2006

Chapter 6 page 121

.   G   /     O -     Submitted for publication

" F  $&$

Discussion

" E  $F$

3      G /

page 179

Curriculum vitae and list of publications

  $EH

Nawoord

(9)

Referenties

GERELATEERDE DOCUMENTEN

#$" / # * $" * & >?:@A QR >< ?:RQ2R' =& nardilysin-dependent CTL epitopes may also be over-expressed in cells that are treated with / >2 / insensitive

Ook al laat de natuurlijke afweer tegen kanker het afweten, deze valt wel op te wekken met 3 %& $= 4 & % " 1 / &&0 3 ook nog het co-stimulatie signaal in de

Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden.. Note: To cite this publication please use the final

2 De vraag is niet of een cytosolisch peptidase bijdraagt aan enerzijds de afbraak van potentiële HLA klasse I-gepresenteerde peptiden óf anderzijds de vorming van

Peripheral blood cells were stained with HLA-A2.1 tetramers containing the tyrosinase368–376 peptide followed by staining with a panel of lineage antibodies, as described in

Blades and blade fragments seem to have been especially used for longitudinal motions, mainly on plant material (7/12). Flake and flake fragments are used in different motions on

This shape also occurs in the combination artefacts (see below). The shape is the result of intensive use in a repetitive abrasive motion, carried out from different angles. In

Since expression of Serpins may facilitate the immune escape of HLA positive tumors, we next analysed the effect of Serpin expression on survival in cases with normal/partial