Mineralocorticoid receptor gene variants : implications for stress, blood pressure and personality Leeuwen, N. van

The research described in this thesis was performed at the division of Medical Pharmacology of the Leiden/ Amsterdam Center for Drug Research and the Leiden University Medical

Furthermore, this SNP is associated with increased morning cortisol suppression after a low dose dexamethasone (0.25mg), heterozygotes of the SNP had higher cortisol and ACTH

The program TFSEARCH (http://www.rwcp.or.jp/papia/ Heinemeyer 1998) was used to identify transcription factor binding sites, UTR-scan was used to identify regulatory regions in the

The MR-2G variant (dashed circle) showed a lower transactivation capacity compared with the MR-2C variant (black triangle) (cortisol p<0.001; dexamethasone p<0.01)..

Following the Weinberger’s test, the ratio of salt sensitive to salt resistant subjects was not significantly different among genotypes (χ 2 1 =1.69, P=0.43) and there was

Moreover, in a well characterized cohort of 166 school teachers these haplotypes have been associated with perceived chronic stress (Trier Inventory for the Assessment of

In conclusion, there are two main haplotype blocks in the MR, these blocks were not associated with mood and/or anxiety disorders but there was an association with neuroticism in

MR-2G/C influences the expression of the MR and this not only affects cortisol mediated transactivation, also aldosterone mediated transactivation is altered by the SNP (in