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A new mechanism of antimalarial drug resistance regulated at the epigenetic level
Mira Martínez, S.
2018
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Mira Martínez, S. (2018). A new mechanism of antimalarial drug resistance regulated at the epigenetic level.
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LIST OF FIGURES
Figure 1. Map of malaria-endemic areas. ... Error! Bookmark not defined.
Figure 2. Malaria life cycle. ... Error! Bookmark not defined.
Figure 3. Limit of detection of the currently used diagnostic methods.Error! Bookmark not defined. Figure 4. History of the introduction of the principial antimalarials and of the first emergence of resistance in the field. ... Error! Bookmark not defined.
Figure 5. Molecular targets and mechanisms of resistance for major antimalarial drugs. ... Error!
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Figure 6. Schematic of adaptation via bet-hedging strategy. ... Error! Bookmark not defined.
Figure 7. Model for the regulation of variant expression and stage-specific expression of clonally variant genes.. ... Error! Bookmark not defined.
Figure 8. Schematic of the different biological processes in P. falciparum regulated at the epigenetic level along the life cycle. ... Error! Bookmark not defined.
Figure 9. Schematic of a P. falciparum merozoite with its key organelles labeled.Error! Bookmark not defined.
Figure 10. Schematic of the gene structures for the five members of the clag family, rhoph2 and
rhoph3 in P. falciparum. ... Error! Bookmark not defined.
Figure 11. clag family phylogenetic analysis and clag3 structure. (A) Bayesian phylogeny of CLAG protein sequences. ... Error! Bookmark not defined.
Figure 12. PSAC is a transmembrane channel exposed at the surface of the infected RBC. ... Error!
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Figure 14. Mind map of factors involved in Drug Resistance in Malaria Parasites.Error! Bookmark not defined.
Figure 15. Schematic of clag3-dependent BS-permeability. ... Error! Bookmark not defined.
Figure 16. Schematic representation of CLAG3.1 and CLAG3.2 genes, showing regions proposed to determine general permeability (NtCR) and efficiency of transport of specific solutes (HVR). .. Error!
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Figure 17. Schematic of compounds that require CLAG3-containing PSAC and those that cross the membrane by passive diffusion or using other transport pathways. ... Error! Bookmark not defined.
Figure 18. Schematic representation of the model of different RhopH complexes and PSAC formed by RhopH1, Rhoph2 and one member of the RhopH1/CLAG family. ... Error! Bookmark not defined.
Figure 19. Schematic representing of the model of different PSAC channels formed by members of the CLAG family. ... Error! Bookmark not defined.
