High dose chemotherapy and autologous hematopoietic stem cell
transplantation for rheumatoid arthritis
Verburg, R.J.
Citation
Verburg, R. J. (2005, October 26). High dose chemotherapy and autologous hematopoietic
stem cell transplantation for rheumatoid arthritis. Retrieved from
https://hdl.handle.net/1887/3491
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from:
https://hdl.handle.net/1887/3491
HIGH DOSE CHEMOTHERAPY AND AUTOLOGOUS
HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR
RHEUMATOID ARTHRITIS.
HIGH DOSE CHEMOTHERAPY AND AUTOLOGOUS
HEMATOPOIETIC STEM CELL TRANSPLANTATION
FOR RHEUMATOID ARTHRITIS.
PROEFSCHRIFT
Ter v
erkri
j
gi
ng v
an
de graad van Doc
tor aan de Uni
v
ers
i
tei
t van Lei
den,
op gezag v
an de Rec
tor Magni
f
i
c
us
Dr. D.D. Brei
mer,
hoogl
eraar i
n de f
ac
ul
tei
t der W i
s
kunde en
Natuurwetens
c
happen en di
e der Genees
kunde,
v
ol
gens
het bes
l
ui
t v
an het Col
l
ege v
oor Promoti
es
te v
erdedi
gen op woens
dag 26 oktober 2005
kl
okke 16.15 uur
door
Promotor: Prof. Dr. F.C. Breedveld Co-promotor: Dr. J.M. van Laar
Referent: Prof. Dr. A. Tyndall (Rheumatologische Universitäts Klinik, Basel, Switserland)
Leden: Prof. Dr. J.D. Isaacs (University of Leeds, Leeds, United Kingdom)
Prof. Dr. W.E. Fibbe Prof. Dr. R.R.P. de Vries
Omslag: L. Vreeken-Bos Omslag lay-out: K.W. IJdema
ISBN-10: 9090198784 ISBN-13: 9789090198781
The printing of this thesis was financially supported by:
5
Contents
Chapter 1 Introduction and aim of studies 7 Adapted from: High dose chemotherapy and autologous
hematopoietic stem cell transplantation for rheumatoid arthritis; a review.
Human Immunology. 2002;63:627-637
Chapter 2 High dose chemotherapy followed by autologous peripheral blood 19 stem cell transplantation or conventional pharmacological treatment for refractory rheumatoid arthritis? A Markov decision analysis. Journal of Rheumatology. 2001;28:719-727.
Chapter 3 High dose chemotherapy and hematopoietic stem cell 43 transplantation: a study of treatment preference in patients with
rheumatoid arthritis and rheumatologists. Journal of Rheumatology. 2002;29:1653-1658.
Chapter 4 High dose chemotherapy and autologous hematopoietic stem cell 59 transplantation in patients with rheumatoid arthritis: results of an open study to assess feasibility, safety, and efficacy.
Arthritis Rheumatism. 2001;44:754-760.
Chapter 5 High dose chemotherapy and autologous stem cell transplantation 75 significantly reduces the rate of joint damage in severe rheumatoid arthritis.
Arthritis Rheumatism. 2005;52:421-424.
Chapter 6 The outcome of intensive immunosuppression and autologous 87 stemcell transplantation in patients with severe rheumatoid
arthritis is associated with the composition of synovial T cell infiltration.
Annals of Rheumatic Diseases.2005;64:1397-1405
Chapter 7 IL-7 deficiency in rheumatoid arthritis: Consequences 111 for therapy induced lymphopenia.
Arthritis Research & Therapy. 2005;7:80-92.
Chapter 8 Long term follow-up of health status in patients with severe 137 rheumatoid arthritis after high dose chemotherapy followed by
autologous stem cell transplantation. Arthritis Rheumatism. 2005;52:2272-2276.
Chapter 9 Summary and discussion 149
Samenvatting en discussie 159
Publications 163
Curriculum vitae 165
