Citation
Vu, M. K. (2007, September 25). Physiology and pathophysiology of the ileal brake in
humans. Department Gastroentero-hepatolgy, Medicine / Leiden University Medical Center (LUMC), Leiden University. Retrieved from https://hdl.handle.net/1887/12350
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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PHYSIOLOGY AND PATHOPHYSIOLOGY
OF THE ILEAL BRAKE IN HUMANS
PHYSIOLOGY AND PATHOPHYSIOLOGY
OF THE ILEAL BRAKE IN HUMANS
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 25 september 2007 te klokke 13.45 uur
door My Kieu Vu geboren te Hanoi
in 1970
Referent:
Prof. dr. J.B.M. J. Jansen (Universiteit Nijmegen)
Overige leden:
Prof. dr. D.W. Hommes Prof. dr. A. van der Laarse
Prof. dr. R.J. Brummer (Universiteit Maastricht)
Prof. dr. J.M. van Laar (Newcastle University, England) Dr. H.P. Peters (Unilever Food & Health Research Institute) Dr. I. Biemond
Part of the studies in this thesis were financially supported by a grant from the Maag Darm Lever Stichting, The Netherlands
The printing of this thesis was financially supported by ALTANA Pharma BV, Janssen-Cilag BV, Astra Zeneca BV, Tramedico BV, Novartis Pharma BV, Abbott BV and Schering Plough BV.
For Ben
CONTENTS
Chapter 1: Introduction, aims and outlines of the thesis 9 PHYSIOLOGY OF THE ILEAL BRAKE
Chapter 2: Does the intestinal site of fat delivery influence feedback control on gastrointestinal motility in humans ? 29 Chapter 3: Does jejunal feeding activate exocrine pancreatic secretion ?
Eur J Clin Invest. 1999 Dec;29(12):1053-9 55 Chapter 4: Effect of the ileal brake on satiety and proximal gastric
function: is it peptide YY ? 65
Chapter 5: Medium chain triglycerides activate distal but not proximal gut hormones
Clin Nutr. 1999 Dec;18(6):359-63 95 Chapter 6: The osmotic laxative magnesium sulphate activates the
ileal brake
Aliment Pharmacol Ther. 2000 May;14(5):587-95 103
PATHOPHYSIOLOGY OF THE ILEAL BRAKE
Chapter 7: Antroduodenal motility in chronic pancreatitis: are abnormalities related to exocrine insufficiency ? Am J Physiol Gastrointest Liver Physiol. 2000 Mar;278
(3):G458-66 115 Chapter 8: Gastrointestinal motility and peptide secretion in
systemic sclerosis 127
Chapter 9: Gallbladder motility in Crohn disease: influence of disease localization and bowel resection
Scand J Gastroenterol. 2000 Nov;35(11):1157-62 151 Chapter 10: Summary
Samenvatting 159
