University of Groningen
Fetal programming in pregnancy-associated disorders
Stojanovska, Violeta
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Publication date: 2018
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Stojanovska, V. (2018). Fetal programming in pregnancy-associated disorders: Studies in novel preclinical models. University of Groningen.
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These propositions belong to the PhD thesis entitled
Fetal programming in pregnancy-associated disorders
Studies in novel preclinical models
1. The use of several animal models of preeclampsia could help to distinguish the independent and/or dependent contribution of each of these factors to the developmental programming of offspring health (this thesis). 2. Despite limited changes in the maternal physiology, exposure to a high sFlt-1 concentration from middle to the end of gestation results in fetal growth restriction (this thesis).
3. Preeclampsia is closely linked to the metabolic syndrome on several levels (this thesis).
4.A double hit exposure to antiangiogenic factors and low-grade inflammation is useful in deploying a comprehensive in vivo model for preeclampsia (this thesis).
5. Intrauterine growth restriction due to placental insufficiency leads to sex-specific adaptations in adult life (this thesis).
6. Impaired insulin signaling during diabetes leads to changes in the cholesterol metabolism of the liver and the brain (this thesis).
7. If knowledge can create problems, it is not through ignorance that we can solve them (Isaac Asimov)
Violeta Stojanovska 5th February 2018
