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University of Groningen Non-invasive markers to investigate vascular damage in systemic disease Hop, Hilde

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University of Groningen

Non-invasive markers to investigate vascular damage in systemic disease

Hop, Hilde

DOI:

10.33612/diss.169290130

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Hop, H. (2021). Non-invasive markers to investigate vascular damage in systemic disease. University of Groningen. https://doi.org/10.33612/diss.169290130

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Non-invasive markers to investigate

vascular damage in systemic disease

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Financial support for printing of this thesis was kindly provided by:

University of Groningen, Graduate School of Medical Sciences and Stichting tot bevordering van onderzoek en onderwijs op het gebied van haemostase, trombose en rheologie Groningen.

Non-invasive markers to investigate vascular damage in systemic disease Hilde Hop

Copyright © 2021 Hilde Hop

All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.

Cover design by Evelien Jagtman | evelienjagtman.com

Layout and design by Harma Makken | persoonlijkproefschrift.nl Printing by Ridderprint | ridderprint.nl

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Non-invasive markers to

investigate vascular damage

in systemic disease

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 19 mei 2021 om 14.30 uur

door

Hilde Hop

geboren op 12 februari 1989 te Elburg

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Promotores Prof. dr. P.W. Kamphuisen Prof. dr. K. Meijer Copromotores Dr. J.D. Lefrandt Dr. D.J. Mulder Beoordelingscommissie

Prof. dr. A.J. Smit Prof. dr. R.A.J.O. Dierckx Prof. dr. R.E.G. Schutgens

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Paranimfen

Fiona Maas Jelle Hop

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TABLE OF CONTENTS

Chapter 1 General introduction and aims 9

Chapter 2 18F-sodium fluoride positron emission tomography assessed microcalcifications in culprit and non-culprit human carotid plaques

27

Chapter 3 Serum calcification propensity in type 1 diabetes associates with mineral stress

53

Chapter 4 Evaluation of the ankle brachial index in persons with hemophilia – a cross sectional study

67

Chapter 5 Carotid plaque composition in persons with hemophilia: an explorative study with multi-contrast MRI

85

Chapter 6 Diagnostic value of axillary artery ultrasound in patients with suspected giant cell arteritis

105

Chapter 7 Summary and general discussion 129

Nederlandse samenvatting 161

Dankwoord 171

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