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University of Groningen

Thermodynamic and stoichiometric constraint-based inference of metabolic phenotypes

Leupold, Karl Ernst Simeon

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Leupold, K. E. S. (2018). Thermodynamic and stoichiometric constraint-based inference of metabolic phenotypes. University of Groningen.

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Stellingen

behorende bij het proefschrift

Thermodynamic and stoichiometric

constraint-based inference of

metabolic phenotypes

Karl Ernst Simeon Leupold

1. “[…] the essential thing in metabolism is that the organism succeeds in freeing itself from all the entropy it cannot help producing while alive.” Erwin Schrödinger

2. There exists an upper rate limit at which cells can dissipate Gibbs energy (i.e. free themselves from produced entropy) (Chapter 2). 3. This limit in conjunction with the desire to maximize growth governs

the way cells operate their metabolism (Chapter 2).

4. The limit in the rate of cellular Gibbs energy dissipation could be explained by a critical limit in intracellular non-thermal fluctuations above which cellular functioning would be compromised (Chapter 2 and 5).

5. The age-related metabolism of S. cerevisiae is characterized by low glucose uptake rates, low growth rates accompanied by a switch from fermentation to respiration.

6. “Trust those who seek the truth but doubt those who say they have found it.” André Gide

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