University of Groningen
Extracellular matrix molecules applied to promote functional survival of microencapsulated pancreatic islets
Llacua Carrasco, Luis Alberto
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Publication date: 2018
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Llacua Carrasco, L. A. (2018). Extracellular matrix molecules applied to promote functional survival of microencapsulated pancreatic islets. University of Groningen.
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Extracellular Matrix
Molecules to Enhance
Functional Survival
of Microencapsulated
Pancreatic Islets
L. Alberto Llacua
The researh described in this thesis was enterely performed at the Deparmento of Pathology and Medical Biology, section Immunoendocrinology of the University Medical Center Groningen (UMCG) within the W.J. Kolf Instiute for Biomedical Engineering and Materials Science.
This work was financial supported by the Erasmus Mundus Lindo (scholarship ML12FD0331) and the Juvenile Diabetes Research Foundation (Grant No. 2013-2953).
The printing of this thesis was financially supported by:
W.J.Kolff Institute for Biomedical Engineering and Materials Science Gronginen, The Netherlands
Copyright 2018 by Luis Alberto Llacua Carrasco
All righst reserved. No part of this publication may be reproduced or transmitted in any form or by any means without written permission of the author and, when appropiate, the publisher holding the the copurights of the published articles
ISBN
978-94-034-1095-1 (Printed) 978-94-034-1094-4 (Digital)
Cover idea and design: L. Alberto Llacua Carrasco
Back cover: “Structure connections of Machu Picchu” Front cover: “Microarchitecture of the islet fascia’
Lay-out: L. Alberto Llacua Carrasco
Extracellular matrix molecules
to enhance functional survival of
microencapsulated pancreatic islets
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 7 November 2018 at 12.45 hours
by
Luis Alberto Llacua Carrasco
born on September 03, 1988 in Lima, Peru
Promotor (s)
Prof. Paul de Vos:
Co-Promotor (s)
PhD. Marijke Faas
Assessment committee
Prof. D. Stamatialis Prof. M.C. Harmsen Prof. A.J.W. Scheurink
Paranymphs
Désirée Goubert Vincent Le Corre
“Keep looking ahead without turning back, but just remember that perhaps the hardest rock in the world is just on the other side of your mirror.”
“Probably of all our feelings the only one which really doesn’t belong to us is hope. Hope belongs to life, it’s life itself defending itself.”
- Julio Cortázar, Hopscotch
Contents
Chapter 1.
General introduction:Extracellular matrix molecules and potential contribution to function of transplanted pancreatic islets
Diabetologia, 2017; DOI: 10.1007/s00125-017-4524-8
Chapter 2.
Extracellular matrix components supporting human islet function in alginate-based immunoprotective microcapsules for treatment of diabetesJournal of biomedical materials research Part A, 2016; 104: 1788-1796
Chapter 3.
Laminin and collagen IV inclusion in immunoisolating microcapsules reduces cytokine-mediated cell death in human pancreatic isletsJournal of tissue engineering and regenerative medicine, 2017; DOI: 10.1002/term.2472
