Transdermal iontophoretic delivery of dopamine agonists: in vitro - in vivo correlation based on novel compartmental modeling

Transdermal iontophoretic delivery of dopamine agonists: in vitro - in vivo correlation based on novel compartmental modeling..

Flux versus time profiles for a 0.5 mg ml -1 rotigotine (close square) and 1.4 mg ml -1 rotigotine (close triangle) donor solution using PBS pH 7.4 as acceptor compartment medium

To obtain more information on the mechanism of rotigotine iontophoretic transport, we decided to study the influence of the following parameters on the iontophoretic

Although very potent, its utility in per-oral delivery is limited due to a low bioavailability (approximately 1% (21)) as a consequence of an extensive metabolism

The fitting result (I) and the evaluation of the predicted flux versus observed flux (II) and the weighted residual sum of square versus predicted flux (III) based on the naïve

Typical examples of the observed data (closed circle), the prediction based on the constant input model (dashed line) and the prediction based on the time-variant input

The observed data of flux (filled circles) following transdermal iontophoresis in vitro of 5-OH-DPAT in DRS presented together with the population model prediction

the turnover and concentration required to cause 50% of the maximum inhibition of dopamine release. From this study it is concluded that: 1) the results of